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Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar.

Abstract：

:Vitamin D and calcium supplements are commonly used, often together, to optimize bone health. Multiple observational studies have linked low serum 25-hydroxyvitamin D concentrations with increased cardiovascular risk. However, subsequent randomized controlled trials (RCTs) failed to demonstrate cardiovascular benefit with vitamin D supplementation. Although vitamin D supplements do not appear to be harmful for cardiovascular health, the lack of benefit in RCTs should discourage their use for this purpose, favoring optimizing vitamin D status through healthy lifestyles such as specific foods and modest sunlight exposure. Furthermore, some (but not all) observational and RCT studies of calcium supplementation have suggested potential for cardiovascular harm. Therefore, calcium supplementation should be used cautiously, striving for recommended intake of calcium predominantly from food sources. In this review, the authors examine the currently available evidence investigating whether vitamin D and calcium supplements are helpful, harmful, or neutral for cardiovascular health.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Michos ED,Cainzos-Achirica M,Heravi AS,Appel LJ

doi

10.1016/j.jacc.2020.09.617

subject

Has Abstract

pub_date

2021-02-02 00:00:00

pages

437-449

issue

4

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(20)37914-6

journal_volume

77

pub_type

杂志文章,评审

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