Radial versus femoral randomized investigation in ST-segment elevation acute coronary syndrome: the RIFLE-STEACS (Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome) study.

Abstract:

OBJECTIVES:The purpose of this study was to assess whether transradial access for ST-segment elevation acute coronary syndrome undergoing early invasive treatment is associated with better outcome compared with conventional transfemoral access. BACKGROUND:In patients with acute coronary syndrome, bleeding is a significant predictor of worse outcome. Access site complications represent a significant source of bleeding for those patients undergoing revascularization, especially when femoral access is used. METHODS:The RIFLE-STEACS (Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome) was a multicenter, randomized, parallel-group study. Between January 2009 and July 2011, 1,001 acute ST-segment elevation acute coronary syndrome patients undergoing primary/rescue percutaneous coronary intervention were randomized to the radial (500) or femoral (501) approach at 4 high-volume centers. The primary endpoint was the 30-day rate of net adverse clinical events (NACEs), defined as a composite of cardiac death, stroke, myocardial infarction, target lesion revascularization, and bleeding). Individual components of NACEs and length of hospital stay were secondary endpoints. RESULTS:The primary endpoint of 30-day NACEs occurred in 68 patients (13.6%) in the radial arm and 105 patients (21.0%) in the femoral arm (p = 0.003). In particular, compared with femoral, radial access was associated with significantly lower rates of cardiac mortality (5.2% vs. 9.2%, p = 0.020), bleeding (7.8% vs. 12.2%, p = 0.026), and shorter hospital stay (5 days first to third quartile range, 4 to 7 days] vs. 6 [range, 5 to 8 days]; p = 0.03). CONCLUSIONS:Radial access in patients with ST-segment elevation acute coronary syndrome is associated with significant clinical benefits, in terms of both lower morbidity and cardiac mortality. Thus, it should become the recommended approach in these patients, provided adequate operator and center expertise is present. (Radial Versus Femoral Investigation in ST Elevation Acute Coronary Syndrome [RIFLE-STEACS]; NCT01420614).

journal_name

J Am Coll Cardiol

authors

Romagnoli E,Biondi-Zoccai G,Sciahbasi A,Politi L,Rigattieri S,Pendenza G,Summaria F,Patrizi R,Borghi A,Di Russo C,Moretti C,Agostoni P,Loschiavo P,Lioy E,Sheiban I,Sangiorgi G

doi

10.1016/j.jacc.2012.06.017

subject

Has Abstract

pub_date

2012-12-18 00:00:00

pages

2481-9

issue

24

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(12)02366-2

journal_volume

60

pub_type

杂志文章,多中心研究,随机对照试验
  • B-type natriuretic peptide and prognosis in heart failure patients with preserved and reduced ejection fraction.

    abstract:OBJECTIVES:This study sought to determine the prognostic value of B-type natriuretic peptide (BNP) in patients with heart failure with preserved ejection fraction (HFPEF), in comparison to data in HF patients with reduced left ventricular (LV) EF (≤40%). BACKGROUND:Management of patients with HFPEF is difficult. BNP i...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2012.12.044

    authors: van Veldhuisen DJ,Linssen GC,Jaarsma T,van Gilst WH,Hoes AW,Tijssen JG,Paulus WJ,Voors AA,Hillege HL

    更新日期:2013-04-09 00:00:00

  • Beta-blocker use and survival in patients with ventricular fibrillation or symptomatic ventricular tachycardia: the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial.

    abstract:OBJECTIVES:To evaluate whether use of beta-adrenergic blocking agents, alone or in combination with specific antiarrhythmic therapy, is associated with improved survival in persons with ventricular fibrillation (VF) or symptomatic ventricular tachycardia (VT). BACKGROUND:The ability of beta-blockers to alter the morta...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0735-1097(99)00234-x

    authors: Exner DV,Reiffel JA,Epstein AE,Ledingham R,Reiter MJ,Yao Q,Duff HJ,Follmann D,Schron E,Greene HL,Carlson MD,Brodsky MA,Akiyama T,Baessler C,Anderson JL

    更新日期:1999-08-01 00:00:00

  • Ventricular function and infarct size: the Western Washington Intravenous Streptokinase in Myocardial Infarction Trial.

    abstract::The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Trial randomized 368 patients with symptoms and signs of acute myocardial infarction of less than 6 h duration to either conventional care or 1.5 million units of intravenous streptokinase. The mean time to randomization was 209 min and 52...

    journal_title:Journal of the American College of Cardiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0735-1097(88)90197-0

    authors: Ritchie JL,Cerqueira M,Maynard C,Davis K,Kennedy JW

    更新日期:1988-04-01 00:00:00

  • Prognostic value of myocardial infarct size and contractile reserve using magnetic resonance imaging.

    abstract:OBJECTIVES:Our aim was to assess the predictive value of myocardial infarct size assessed with late gadolinium-enhanced (LGE) magnetic resonance imaging (MRI) in medically treated patients with chronic myocardial infarction relative to contractile reserve on low-dose dobutamine magnetic resonance (DSMR) for long-term e...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jacc.2009.07.027

    authors: Kelle S,Roes SD,Klein C,Kokocinski T,de Roos A,Fleck E,Bax JJ,Nagel E

    更新日期:2009-11-03 00:00:00

  • Potentiation of Doxorubicin cardiotoxicity by iron loading in a rodent model.

    abstract:OBJECTIVES:The role of iron toward doxorubicin (DOX) cardiotoxicity was studied using a rodent model of dietary carbonyl iron loading. BACKGROUND:Doxorubicin, a commonly used anticancer drug, is known to cause serious and potentially life-threatening cardiotoxicity. Doxorubicin cardiotoxicity is thought to be mediated...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2007.02.060

    authors: Panjrath GS,Patel V,Valdiviezo CI,Narula N,Narula J,Jain D

    更新日期:2007-06-26 00:00:00

  • Revascularization in severe left ventricular dysfunction.

    abstract::The highest-risk patients with heart failure with reduced ejection fraction are those with ischemic cardiomyopathy and severe left ventricular systolic dysfunction (ejection fraction≤35%). The cornerstone of treatment is guideline-driven medical therapy for all patients and implantable device therapy for appropriately...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2014.10.070

    authors: Velazquez EJ,Bonow RO

    更新日期:2015-02-17 00:00:00

  • A Combination of Allogeneic Stem Cells Promotes Cardiac Regeneration.

    abstract:BACKGROUND:The combination of autologous mesenchymal stem cells (MSCs) and cardiac stem cells (CSCs) synergistically reduces scar size and improves cardiac function in ischemic cardiomyopathy. Whereas allogeneic (allo-)MSCs are immunoevasive, the capacity of CSCs to similarly elude the immune system remains controversi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2017.09.036

    authors: Natsumeda M,Florea V,Rieger AC,Tompkins BA,Banerjee MN,Golpanian S,Fritsch J,Landin AM,Kashikar ND,Karantalis V,Loescher VY,Hatzistergos KE,Bagno L,Sanina C,Mushtaq M,Rodriguez J,Rosado M,Wolf A,Collon K,Vincent L,

    更新日期:2017-11-14 00:00:00

  • Safety and efficacy of tissue-type plasminogen activator produced by recombinant DNA technology.

    abstract::Because of its enhanced activation of plasminogen in association with fibrin compared with free plasminogen, tissue-type plasminogen activator (t-PA) evoked excitement as a potentially useful pharmacologic activator of the fibrinolytic system. Initial studies in experimental animals and patients demonstrated that it i...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(87)80427-8

    authors: Sobel BE

    更新日期:1987-11-01 00:00:00

  • Primary restrictive cardiomyopathy: clinical and pathologic characteristics.

    abstract::Twenty-four patients with restrictive cardiomyopathy were identified at St. Thomas' Hospital during a 17-year period. All had endomyocardial biopsy, but in two patients the biopsy specimens were small and nondiagnostic. Seven patients had amyloidosis and five had other specific heart muscle diseases. The remaining 10 ...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(91)90540-p

    authors: Katritsis D,Wilmshurst PT,Wendon JA,Davies MJ,Webb-Peploe MM

    更新日期:1991-11-01 00:00:00

  • Insulin resistance, lipoproteins, body fat and hemostasis in nonobese men with angina and a normal or abnormal coronary angiogram.

    abstract:OBJECTIVES:The aim of this study was to compare metabolic risk factors in men with anginal chest pain and a normal or abnormal coronary angiogram with those in healthy men. BACKGROUND:Risk factors for coronary heart disease, including lipoprotein abnormalities, hypertension and adiposity, may be metabolically interlin...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(94)90423-5

    authors: Ley CJ,Swan J,Godsland IF,Walton C,Crook D,Stevenson JC

    更新日期:1994-02-01 00:00:00

  • Progression of central pulse pressure over 1 decade of aging and its reversal by nitroglycerin a twin study.

    abstract:OBJECTIVES:The goal of this study was to examine the progression of central arterial pulse pressure (cPP) in women and the degree to which this can be reversed by nitrovasodilation. BACKGROUND:cPP can be partitioned into height of the first systolic shoulder (P1), generated by a forward pressure wave and related to ar...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2011.10.871

    authors: Cecelja M,Jiang B,Spector TD,Chowienczyk P

    更新日期:2012-01-31 00:00:00

  • Role of adenosine thallium-201 tomography for defining long-term risk in patients after acute myocardial infarction.

    abstract:OBJECTIVES:This study prospectively evaluated whether early assessment with adenosine thallium-201 tomography could better refine risk stratification on the basis of absolute extent of myocardial ischemia in postinfarction patients in clinically stable condition. BACKGROUND:Postinfarction patients are at increased ris...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(95)00016-W

    authors: Mahmarian JJ,Mahmarian AC,Marks GF,Pratt CM,Verani MS

    更新日期:1995-05-01 00:00:00

  • Influence of contemporary versus 30-year blood pressure levels on left ventricular mass and geometry: the Framingham Heart Study.

    abstract::To determine whether long-term blood pressure levels correlate with left ventricular mass, echocardiographic measurements were performed in 152 men and 299 women who were participants in the Framingham Heart Study. All subjects were free of obesity and cardiovascular and pulmonary disease, were not taking antihyperten...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(91)90549-o

    authors: Lauer MS,Anderson KM,Levy D

    更新日期:1991-11-01 00:00:00

  • Effect of Evolocumab on Complex Coronary Disease Requiring Revascularization.

    abstract:OBJECTIVES:This study sought to evaluate the ability of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor evolocumab to reduce the risk of complex coronary atherosclerosis requiring revascularization. BACKGROUND:PCSK9 inhibitors induce plaque regression and reduce the risk of coronary revascularizati...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2020.11.011

    authors: Oyama K,Furtado RHM,Fagundes A Jr,Zelniker TA,Tang M,Kuder J,Murphy SA,Hamer A,Wang H,Keech AC,Giugliano RP,Sabatine MS,Bergmark BA

    更新日期:2021-01-26 00:00:00

  • Clinical and electrophysiological spectrum of idiopathic ventricular outflow tract arrhythmias.

    abstract:OBJECTIVES:This study sought to compare and contrast the clinical and electrophysiological characteristics of outflow tract arrhythmias. BACKGROUND:Idiopathic ventricular outflow tract arrhythmias manifest clinically in 3 forms: 1) paroxysmal sustained monomorphic ventricular tachycardia (SMVT), 2) repetitive nonsusta...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2007.01.085

    authors: Kim RJ,Iwai S,Markowitz SM,Shah BK,Stein KM,Lerman BB

    更新日期:2007-05-22 00:00:00

  • Arrhythmias after the Mustard operation for transposition of the great arteries: a long-term study.

    abstract::This study presents follow-up data on 95 patients with transposition of the great arteries who underwent a Mustard intraatrial baffle operation. The patients were followed up serially by means of scalar electrocardiograms and 24 hour Holter monitoring studies. The latter study was effective in documenting abnormal rhy...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(86)80270-4

    authors: Hayes CJ,Gersony WM

    更新日期:1986-01-01 00:00:00

  • ACC/AHA Versus ESC/ESH on Hypertension Guidelines: JACC Guideline Comparison.

    abstract::This study compares the recommendations of the most recent American College of Cardiology (ACC)/American Heart Association (AHA) and European Society of Cardiology (ESC)/European Society of Hypertension (ESH) blood pressure guidelines. Both guidelines represent updates of previous guidelines and reinforce previous con...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jacc.2019.03.507

    authors: Bakris G,Ali W,Parati G

    更新日期:2019-06-18 00:00:00

  • High prevalence of atrial fibrosis in patients with dilated cardiomyopathy.

    abstract:OBJECTIVES:We examined the extent of fibrotic changes in the left atrium of cardiomyopathic human hearts and investigated the relation of mechanical overload caused by left ventricular dysfunction to fibrosis of the left atrium. BACKGROUND:Left atrial dysfunction in dilated cardiomyopathy may contribute to progression...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(94)00529-y

    authors: Ohtani K,Yutani C,Nagata S,Koretsune Y,Hori M,Kamada T

    更新日期:1995-04-01 00:00:00

  • An experimental model of acute and subacute viral myocarditis in the pig.

    abstract::Twenty-six young pigs were infected with encephalomyocarditis virus, observed clinically, studied at intervals by noninvasive and invasive methods to assess cardiac function and eventually examined pathologically. All infected animals appeared ill, usually manifesting diminished appetite, lethargy and fever. Spontaneo...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(92)90533-s

    authors: Gwathmey JK,Nakao S,Come PC,Goad ME,Serur JR,Als AV,Abelmann WH

    更新日期:1992-03-15 00:00:00

  • Mechanism of syncope in patients with positive adenosine triphosphate tests.

    abstract:OBJECTIVES:We prospectively evaluated the mechanism of syncope in patients with positive adenosine triphosphate (ATP) tests (defined as the induction of atrioventricular [AV] block with a ventricular pause >/=6 s after an intravenous bolus of 20 mg ATP). BACKGROUND:Patients with unexplained syncope tend to have more p...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(02)02621-9

    authors: Donateo P,Brignole M,Menozzi C,Bottoni N,Alboni P,Dinelli M,Del Rosso A,Croci F,Oddone D,Solano A,Puggioni E

    更新日期:2003-01-01 00:00:00

  • Carotid Artery Stenting Versus Endarterectomy for Stroke Prevention: A Meta-Analysis of Clinical Trials.

    abstract:BACKGROUND:Data conflict regarding the relative effectiveness of carotid artery stenting (CAS) and carotid artery endarterectomy (CEA) for the prevention of stroke due to carotid artery stenosis. OBJECTIVES:The authors performed an updated meta-analysis evaluating the efficacy and safety of CAS versus CEA, given recen...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.jacc.2017.02.053

    authors: Sardar P,Chatterjee S,Aronow HD,Kundu A,Ramchand P,Mukherjee D,Nairooz R,Gray WA,White CJ,Jaff MR,Rosenfield K,Giri J

    更新日期:2017-05-09 00:00:00

  • High telomerase activity in neutrophils from unstable coronary plaques.

    abstract:OBJECTIVES:We evaluated telomerase activity in circulating polymorphonuclear neutrophils (PMN) and in PMN isolated from coronary atherosclerotic plaques by a novel approach. BACKGROUND:Delayed apoptosis of PMN have been demonstrated in unstable angina (UA). These cells have a finite lifespan with low telomerase activi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/j.jacc.2007.08.048

    authors: Narducci ML,Grasselli A,Biasucci LM,Farsetti A,Mulè A,Liuzzo G,La Torre G,Niccoli G,Mongiardo R,Pontecorvi A,Crea F

    更新日期:2007-12-18 00:00:00

  • Lymphocytic myocarditis presenting as unexplained ventricular arrhythmias: diagnosis with endomyocardial biopsy and response to immunosuppression.

    abstract::During a period of 18 months beginning in January 1982, a total of 65 patients were referred to the Miami Heart Institute for evaluation of either aborted out of hospital sudden death, ventricular tachycardia resistant to standard clinically directed antiarrhythmic medication programs or high grade ventricular arrhyth...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(84)80411-8

    authors: Vignola PA,Aonuma K,Swaye PS,Rozanski JJ,Blankstein RL,Benson J,Gosselin AJ,Lister JW

    更新日期:1984-10-01 00:00:00

  • Diagnosis of coronary stenosis by two-dimensional echographic study of dysfunction of ventricular segments during and immediately after pacing.

    abstract::The adequacy of two-dimensional echocardiography during right atrial pacing for the detection and characterization of coronary artery stenosis was examined in 10 closed chest dogs. Pacing at successively higher rates up to 210 beats/min was carried out in the control state and again during a 70% left anterior descendi...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(83)80309-x

    authors: Kondo S,Meerbaum S,Sakamaki T,Shimoura K,Tei C,Shah PM,Corday E

    更新日期:1983-10-01 00:00:00

  • Polymeric-based perivascular delivery of a nitric oxide donor inhibits intimal thickening after balloon denudation arterial injury: role of nuclear factor-kappaB.

    abstract:OBJECTIVES:To examine the effect of a polymeric-based periadventitial delivery of a nitric oxide (NO)-releasing diazeniumdiolate, spermine/NO (SPER/NO), on balloon injury-induced neointimal hyperplasia in rat ileofemoral arteries. BACKGROUND:Reduced local bioavailability and adverse side effects limit systemic adminis...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(99)00543-4

    authors: Kaul S,Cercek B,Rengstrom J,Xu XP,Molloy MD,Dimayuga P,Parikh AK,Fishbein MC,Nilsson J,Rajavashisth TB,Shah PK

    更新日期:2000-02-01 00:00:00

  • Current perspectives on coronary chronic total occlusions: the Canadian Multicenter Chronic Total Occlusions Registry.

    abstract:OBJECTIVES:The purpose of this study was to determine the prevalence, clinical characteristics, and management of coronary chronic total occlusions (CTOs) in current practice. BACKGROUND:There is little evidence in contemporary literature concerning the prevalence, clinical characteristics, and treatment decisions reg...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jacc.2011.12.007

    authors: Fefer P,Knudtson ML,Cheema AN,Galbraith PD,Osherov AB,Yalonetsky S,Gannot S,Samuel M,Weisbrod M,Bierstone D,Sparkes JD,Wright GA,Strauss BH

    更新日期:2012-03-13 00:00:00

  • Impaired left atrial mechanical function after cardioversion: relation to the duration of atrial fibrillation.

    abstract:OBJECTIVES:We hypothesized that the time course of the recovery of atrial systolic function may be related to the duration of atrial fibrillation before cardioversion and sought to study noninvasively the recovery of left atrial mechanical function utilizing serial transthoracic Doppler studies. BACKGROUND:Recovery of...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(94)90652-1

    authors: Manning WJ,Silverman DI,Katz SE,Riley MF,Come PC,Doherty RM,Munson JT,Douglas PS

    更新日期:1994-06-01 00:00:00

  • Augmented myocardial perfusion reserve after coronary angioplasty quantified by positron emission tomography with H2(15)O.

    abstract::Effects of coronary angioplasty on myocardial flow reserve have been difficult to characterize noninvasively because conventional imaging techniques cannot quantitate blood flow in absolute terms. The effects of coronary angioplasty on myocardial perfusion and perfusion reserve were delineated with positron emission t...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(90)90186-s

    authors: Walsh MN,Geltman EM,Steele RL,Kenzora JL,Ludbrook PA,Sobel BE,Bergmann SR

    更新日期:1990-01-01 00:00:00

  • Direct coronary angioplasty in acute myocardial infarction: outcome in patients with single vessel disease.

    abstract::Percutaneous transluminal coronary angioplasty was performed as primary therapy in 215 consecutive patients (aged 56 +/- 11 years, 75% male) with acute myocardial infarction and single vessel coronary artery disease. Wide patency of the infarct-related artery was restored in 212 patients (99%). Complications consisted...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/0735-1097(90)90621-u

    authors: Stone GW,Rutherford BD,McConahay DR,Johnson WL Jr,Giorgi LV,Ligon RW,Hartzler GO

    更新日期:1990-03-01 00:00:00

  • Potential role of mechanical stress in the etiology of pediatric heart disease: septal shear stress in subaortic stenosis.

    abstract:OBJECTIVES:The objective of this study was to show elevations in septal shear stress in response to morphologic abnormalities that have been associated with discrete subaortic stenosis (SAS) in children. Combined with the published data, this critical connection supports a four-stage etiology of SAS that is advanced in...

    journal_title:Journal of the American College of Cardiology

    pub_type: 杂志文章

    doi:10.1016/s0735-1097(97)00048-x

    authors: Cape EG,Vanauker MD,Sigfússon G,Tacy TA,del Nido PJ

    更新日期:1997-07-01 00:00:00