Abstract：
:Using contrast-enhanced computed tomography, the effects of hyperosmolar mannitol and methylprednisolone on experimentally produced myocardial infarcts were evaluated serially over the course of approximately 1 month. Infarct size, initial perfusion defect (jeopardized segment) and noninfarcted muscle mass were determined in three groups of conditioned mongrel dogs. Group 1 (n = 11) served as the control group, groups 2 and 3 were pretreated with mannitol (375 mg/kg, n = 10) or methylprednisolone (7.5 mg/kg, n = 11). Each animal in the treatment groups was treated with identical doses of the originally administered agent twice daily for 7 days after coronary occlusion. Each group developed increases in the noninfarcted muscle mass of the left ventricle (compensatory hypertrophy). The mean increase averaged more than 20% over 30 days when all groups were included together. Infarct size was smaller in both of the treatment groups. However, at 4 days after infarction, mannitol-treated dogs had a mean infarct size that was 68 +/- 8% (+/- standard error of the mean) of the size of control infarcts (p less than 0.01) and methylprednisolone-treated dogs had a mean infarct size that was 77 +/- 6% of the size of control infarcts (p less than 0.01) (referenced to the initial perfusion defect). At 30 days, these differences were less substantial (though still significant), 88 +/- 4% and 85 +/- 5%, respectively. Pharmacologic interventions can be shown to alter the size of an acute myocardial infarction, particularly when examined over the time course of infarct healing.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Slutsky RA,Murray Mdoi
10.1016/s0735-1097(85)80047-4subject
Has Abstractpub_date
1985-02-01 00:00:00pages
273-9issue
2 Pt 1eissn
0735-1097issn
1558-3597pii
S0735-1097(85)80047-4journal_volume
5pub_type
杂志文章,收录出版abstract：:The ventricular rate and percent of pre-excited QRS complexes during atrial fibrillation were compared in two groups of patients with the Wolff-Parkinson-White syndrome. Group A consisted of 22 patients whose anterograde effective refractory period of the accessory pathway was longer than that of the atrioventricular ...
journal_title：Journal of the American College of Cardiology
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abstract：OBJECTIVES:The goal of this study was to identify differences in shear-induced platelet aggregation (SIPA) between patients who did or did not experience subacute stent thrombosis (SAT). BACKGROUND:Despite dual antiplatelet therapy, SAT after coronary stenting occurs in approximately 1% of patients. There is no accept...
journal_title：Journal of the American College of Cardiology
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abstract：OBJECTIVES:This study sought to assess the prognostic impact of midregional pro-adrenomedullin (MR-proADM) after an acute myocardial infarction (AMI). BACKGROUND:Adrenomedullin (ADM) is elevated in heart failure (HF) and after AMI. Another part of its precursor, MR-proADM, is more stable in circulation and ex vivo. We...
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doi：10.1016/j.jacc.2006.12.038
更新日期：2007-04-10 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
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journal_title：Journal of the American College of Cardiology
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doi：10.1016/0735-1097(96)00102-7
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abstract：OBJECTIVES:This study tested the hypothesis that activation of adenylyl cyclase 6 (AC6) expression in cardiac myocytes improves calcium uptake and left ventricular (LV) function in aging mice. BACKGROUND:Aging hearts exhibit impaired β-adrenergic receptor signaling and LV dysfunction. METHODS:Twenty-month-old mice wi...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
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更新日期：2011-05-03 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/0735-1097(93)90307-m
更新日期：1993-05-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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更新日期：2001-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.jacc.2009.07.043
更新日期：2009-12-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/0735-1097(93)90468-g
更新日期：1993-10-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
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更新日期：2016-04-12 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
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更新日期：1992-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-02-07 00:00:00
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pub_type： 历史文章,杂志文章,评审
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更新日期：1989-05-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究
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更新日期：2018-09-11 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
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更新日期：2017-06-27 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
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更新日期：2009-11-17 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2009-08-04 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
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更新日期：2014-01-28 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1993-03-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1999-02-01 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
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更新日期：2015-06-30 00:00:00
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journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章
doi：10.1016/s0735-1097(87)80045-1
更新日期：1987-03-01 00:00:00
abstract：OBJECTIVES:This study sought to evaluate the safety and feasibility of zotarolimus-eluting stent implantation in focal atherosclerotic lesions of the internal pudendal arteries among men with erectile dysfunction (ED) and a suboptimal response to phosphodiesterase-5 inhibitors. BACKGROUND:ED, a common condition, is of...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.jacc.2012.08.1016
更新日期：2012-12-25 00:00:00
abstract：:Pre-clinical diastolic dysfunction (PDD) has been broadly defined as left ventricular diastolic dysfunction without the diagnosis of congestive heart failure (HF) and with normal systolic function. PDD is an entity that remains poorly understood, yet has definite clinical significance. Although few original studies ha...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,评审
doi：10.1016/j.jacc.2013.10.063
更新日期：2014-02-11 00:00:00
abstract：BACKGROUND:Randomized controlled trials comparing short- (≤6 months) with long-term (≥1 year) dual antiplatelet therapy (DAPT) after drug-eluting stent(s) (DES) placement have been insufficiently powered to detect significant differences in the risk of major adverse cardiac events (MACE). OBJECTIVES:This study sought ...
journal_title：Journal of the American College of Cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jacc.2014.12.046
更新日期：2015-03-24 00:00:00
