Abstract:
:Atrial natriuretic peptide hormone of cardiac origin, which is released in response to atrial distension and serves to maintain sodium homeostasis and inhibit activation of the renin-angiotensin-aldosterone system. Congestive heart failure is a clinical syndrome characterized by increased cardiac volume and pressure overload with an inability to excrete a sodium load, which is associated with increased activity of systemic neurohumoral and local autocrine and paracrine mechanisms. Circulating atrial natriuretic peptide is greatly increased in congestive heart failure as a result of increased synthesis and release of this hormone. Atrial natriuretic peptide has emerged as an important diagnostic and prognostic serum marker in congestive heart failure. In early heart failure, it may play a key role in preserving the compensated state of asymptomatic left ventricular dysfunction. Despite increased circulating atrial natriuretic peptide in heart failure, the kidney retains sodium and is hyporesponsive to exogenous and endogenous atrial natriuretic peptide. The mechanism for the attenuated renal response is multifactorial and includes renal hypoperfusion, activation of the renin-angiotensin-aldosterone and sympathetic nervous systems. Therapeutic strategies to potentiate the biologic actions of atrial natriuretic peptide may prolong the asymptomatic phase and delay progression to overt congestive heart failure.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Brandt RR,Wright RS,Redfield MM,Burnett JC Jrdoi
10.1016/0735-1097(93)90468-gsubject
Has Abstractpub_date
1993-10-01 00:00:00pages
86A-92Aissue
4 Suppl Aeissn
0735-1097issn
1558-3597pii
0735-1097(93)90468-Gjournal_volume
22pub_type
杂志文章,评审abstract:BACKGROUND:Early in the prevention and treatment of bioprosthetic valve thrombosis (BPVT), anticoagulation is effective, but the long-term outcome after BPVT is unknown. OBJECTIVES:The goal of this study was to assess the long-term outcomes of patients with BPVT treated with anticoagulation. METHODS:This analysis was...
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-11-15 00:00:00
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更新日期:2003-10-01 00:00:00
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更新日期:1991-12-01 00:00:00
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更新日期:2020-03-24 00:00:00
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更新日期:2007-12-18 00:00:00