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Safety and efficacy of tissue-type plasminogen activator produced by recombinant DNA technology.

Abstract：

:Because of its enhanced activation of plasminogen in association with fibrin compared with free plasminogen, tissue-type plasminogen activator (t-PA) evoked excitement as a potentially useful pharmacologic activator of the fibrinolytic system. Initial studies in experimental animals and patients demonstrated that it induced coronary thrombolysis rapidly and without concomitant, marked fibrinogenolysis in contrast to streptokinase. Large scale clinical trials soon followed. Their results indicate that intravenous administration of t-PA produced by recombinant DNA technology (rt-PA) elicits coronary thrombolysis in two-thirds or more of treated patients with angiographically documented thrombotic occlusions generally without perturbing hemostatic mechanisms or inducing marked fibrinogenolysis. Bleeding is usually confined to vascular access sites and episodes of major bleeding are rare. Overall 6 week survival for treated patients with documented acute myocardial infarction may be as high as 95%.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Sobel BE

doi

10.1016/s0735-1097(87)80427-8

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

40B-44B

issue

5 Suppl B

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(87)80427-8

journal_volume

10

pub_type

杂志文章

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