Abstract:
:The studies on intact fibers of the frog and fast-twitch skinned fibers of the Syrian hamster suggest the presence of intermediate low-force (weak) and high-force (strong) attachments in the cross-bridge cycle. Our results suggest that the weak and strong attachments may be separately regulated by independent calcium switches. The switch for weak bridges operates by calcium or decreasing ionic strength, such that in low ionic strength in skinned fibers the bridges form even in the virtual absence of TnC and calcium. The weak to strong transition appears to require Ca in both low and high ionic strengths. The Ca action effecting this transition may be mediated also by TnC and/or may involve the myosin moiety. Thus, the possibility is raised that Ca may act at two separate steps in the cross-bridge mechanism under physiological conditions.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Babu A,Gulati Jsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
101-12eissn
0065-2598issn
2214-8019journal_volume
226pub_type
杂志文章abstract::In a mouse model of acute light-induced retinal degeneration, positive correlations between the levels of DHA, the levels of n3 PUFA lipid peroxidation, and the vulnerability to photooxidative stress were observed. On the other hand, higher sensitivity of the electroretinogram a-wave response, a measure of the amplifi...
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journal_title:Advances in experimental medicine and biology
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journal_title:Advances in experimental medicine and biology
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