The significance of variation in the susceptibility of Schistosoma mansoni to the antischistosomal drug oxamniquine.

Abstract:

:Clinical and laboratory evidence is reviewed which shows that there is a great deal of variation in the susceptibility of Schistosoma mansoni to oxamniquine. This variation occurs both among endemic regions and within endemic regions in Brazil and Kenya. It is genetically controlled. It is suggested that the parasite possesses a large capacity for developing resistance to the drug and that resistance will develop where sufficient drug pressure is maintained.

journal_name

Mem Inst Oswaldo Cruz

authors

Kinoti GK

doi

10.1590/s0074-02761987000800026

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

151-6

eissn

0074-0276

issn

1678-8060

pii

S0074-02761987000800026

journal_volume

82 Suppl 4

pub_type

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