Chronic osteomyelitis caused by Staphylococcus aureus: controlled clinical trial of nafcillin therapy and nafcillin-rifampin therapy.

Abstract:

:A controlled trial of treatment of chronic osteomyelitis caused by Staphylococcus aureus compared nafcillin alone with nafcillin plus rifampin for a six-week period. Treatment was well tolerated, the only adverse effect being mild neutropenia in four of 18 patients; no toxicity was observed from rifampin. Eight of ten patients in the combined treatment group had a favorable clinical response (with follow-up of two to four years) as compared to four of eight in the nafcillin group (P = .2). Despite the failure to show a statistically significant advantage of rifampin plus nafcillin, we conclude that the combination, along with appropriate surgery, should be considered for patients with chronic staphylococcal osteomyelitis.

journal_name

South Med J

journal_title

Southern medical journal

authors

Norden CW,Bryant R,Palmer D,Montgomerie JZ,Wheat J

doi

10.1097/00007611-198608000-00008

subject

Has Abstract

pub_date

1986-08-01 00:00:00

pages

947-51

issue

8

eissn

0038-4348

issn

1541-8243

journal_volume

79

pub_type

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