Association Between Maternal-Perceived Psychological Stress and Fetal Telomere Length.

Abstract:

OBJECTIVE:Our study aimed to investigate the association between maternal-perceived psychological stress and fetal telomere length. METHODS:We recruited women in labor upon hospital delivery admission. Based on responses to the Perceived Stress Scale, we categorized participants as having "high," "normal," or "low" perceived stress. We collected umbilical cord blood samples (N = 71) and isolated genomic DNA from cord blood leukocytes using quantitative polymerase chain reaction. We used a ratio of relative telomere length derived by telomere-to-single-copy gene ratio (T/S ratio). We applied analysis of variance and bootstrapping statistical procedures. RESULTS:Sixteen (22.5%) women were classified as having low perceived stress, 42 (59.2%) were classified as having normal perceived stress, and 13 (18.3%) were classified as having high perceived stress. Fetal telomere length differed significantly across the three stress groups in a dose-response pattern (T/S ratio of those with low perceived stress was greater than those with normal perceived stress, which was greater than those with high perceived stress [P < 0.05]). CONCLUSIONS:Our findings support our hypothesis that maternal-perceived psychological stress during pregnancy is associated with shorter fetal telomere length and suggest maternal stress as a possible marker for early intrauterine programming for accelerated chromosomal aging.

journal_name

South Med J

journal_title

Southern medical journal

authors

Salihu HM,King LM,Nwoga C,Paothong A,Pradhan A,Marty PJ,Daas R,Whiteman VE

doi

10.14423/SMJ.0000000000000567

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

767-772

issue

12

eissn

0038-4348

issn

1541-8243

pii

SMJ50295

journal_volume

109

pub_type

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