Abstract:
OBJECTIVE:Our study aimed to investigate the association between maternal-perceived psychological stress and fetal telomere length. METHODS:We recruited women in labor upon hospital delivery admission. Based on responses to the Perceived Stress Scale, we categorized participants as having "high," "normal," or "low" perceived stress. We collected umbilical cord blood samples (N = 71) and isolated genomic DNA from cord blood leukocytes using quantitative polymerase chain reaction. We used a ratio of relative telomere length derived by telomere-to-single-copy gene ratio (T/S ratio). We applied analysis of variance and bootstrapping statistical procedures. RESULTS:Sixteen (22.5%) women were classified as having low perceived stress, 42 (59.2%) were classified as having normal perceived stress, and 13 (18.3%) were classified as having high perceived stress. Fetal telomere length differed significantly across the three stress groups in a dose-response pattern (T/S ratio of those with low perceived stress was greater than those with normal perceived stress, which was greater than those with high perceived stress [P < 0.05]). CONCLUSIONS:Our findings support our hypothesis that maternal-perceived psychological stress during pregnancy is associated with shorter fetal telomere length and suggest maternal stress as a possible marker for early intrauterine programming for accelerated chromosomal aging.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Salihu HM,King LM,Nwoga C,Paothong A,Pradhan A,Marty PJ,Daas R,Whiteman VEdoi
10.14423/SMJ.0000000000000567subject
Has Abstractpub_date
2016-12-01 00:00:00pages
767-772issue
12eissn
0038-4348issn
1541-8243pii
SMJ50295journal_volume
109pub_type
杂志文章abstract::The accuracy of the noninvasive carotid system studies done in our laboratory during an 18-month period were reviewed. The usefulness of these procedures was found to be limited when used as a "blind" screen for extracranial vascular disease. The overall correlation with angiography was good, with few false-negatives ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198205000-00008
更新日期:1982-05-01 00:00:00
abstract::Chordomas are tumors originating from remnants of the notochord, most commonly found in the cranial and caudal regions. This is a report of the seventh intrathoracic chordoma in the world literature and the second to be reported in a woman. Histologically the physalipherous (blister-bearing) cell is characteristic of ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197501000-00029
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:This study examined patient perceptions and attitudes toward various aspects of the male and female physician's professional appearance in the family practice setting. METHODS:Four hundred ninety-six patients from two family practice clinics in Knoxville, Tennessee, completed a valid and reliable questionna...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000077011.58103.C1
更新日期:2003-12-01 00:00:00
abstract::Fifty-four residents in internal medicine and primary care medicine were surveyed before and after receiving a prescription drugs price guide booklet to determine whether providing written price information to the residents would improve their knowledge of drug costs. Results indicated that the pricing information did...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198303000-00015
更新日期:1983-03-01 00:00:00
abstract::Pulmonary alveolar proteinosis is a nonspecific alveolar response to various forms of injuries. Many cases have been associated with hematologic malignancies. The most commonly reported complication of pulmonary alveolar proteinosis is superinfection with fungal, bacterial, and viral infections. We report a case of a ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199608000-00009
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:This study was designed to identify differences among internists in their attitudes about diabetes and how those attitudes influence practice behavior. METHODS:A cross-sectional study of 55 internists in an academic medical center was done using the Diabetes Attitude Scale (DAS-3), a valid and reliable meas...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:The objectives of the study were to determine the percentage of osteopathic emergency medicine (EM) residencies that require an original research project to meet the American Osteopathic Association requirement, describe the resources available to the residents and faculty members to complete their projects,...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000967
更新日期:2019-05-01 00:00:00
abstract::From January 1986 to December 1987, 32 patients with recurrent colorectal cancer had second-look radioimmunoguided surgery (RIGS system). All patients had pathologic confirmation of recurrence. The RIGS system identified 81% of recurrences, and in six patients recurrent tumor was identified only by RIGS. All patients ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Reported is a case of mesenteric venous thrombosis occurring in a 46-year-old woman who had taken an oral contraceptive for six years. Seventeen cases of mesenteric venous thrombosis have been reported in young women taking oral contraceptives. An association between oral contraceptive agents and mesenteric venous thr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197703000-00033
更新日期:1977-03-01 00:00:00
abstract::In an attempt to prevent morbidity and mortality in carotid endarterectomy, we monitored 47 operations with intraoperative EEG to determine which patients should have a shunt during endarterectomy. The EEG was recorded for up to five minutes during test carotid cross-clamping. When EEG asymmetry between the cerebral h...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197908000-00018
更新日期:1979-08-01 00:00:00
abstract::Sarcoidosis rarely involves the genitourinary system or the spinal cord. This report describes a case of sarcoidosis with a scrotal mass, a mass compressing the spinal cord, and lesions in the liver and spleen. This case illustrates an uncommon manifestation of sarcoidosis, which may mimic disseminated testicular canc...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000163306.54629.35
更新日期:2005-09-01 00:00:00
abstract::Mineral oil scrapings from an infant with a persistent, puzzling, generalized eruption revealed the mite, Sarcoptes scabiei. Various diagnostic technics and treatment for scabies are discussed. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197505000-00008
更新日期:1975-05-01 00:00:00
abstract::The number of breast cancer survivors has increased and this increase is expected to continue, likely as a result of population and age growth, the implementation of earlier detection strategies, and the development of more effective therapies. Breast cancer treatment requires a multidisciplinary approach with surgery...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.14423/SMJ.0000000000000701
更新日期:2017-10-01 00:00:00
abstract::Diagnostic peritoneal lavage (DPL) is an established procedure in evaluation of trauma victims but is less well established for use in patients suspected of having acute intra-abdominal disease. Twenty-six seriously ill patients at our institution who had DPL for acute intra-abdominal disease form the basis of this re...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199004000-00015
更新日期:1990-04-01 00:00:00
abstract::We describe two cases of drug-induced hypertriglyceridemia, one associated with interferon alfa-2b and the other with asparaginase, each of which is mediated through a different mechanism. Hypertriglyceridemia caused by these medications is not listed as an adverse reaction in the Physicians' Desk Reference, one of th...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199909000-00013
更新日期:1999-09-01 00:00:00
abstract::Appropriate use of antibiotics is enhanced by the effective application of data on antimicrobial susceptibility. A number of methods are currently available for routine determination of susceptibilities, including agar dilution, broth dilution, agar diffusion, and several semiautomated methods. If susceptibility testi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::Although successful transposition of the ovaries at the time of staging laparotomy for Hodgkin's disease is well documented, little comment has been made on potential complications. This case report of a primary ovarian neoplasm (benign) developing in a transposed ovary serves to alert physicians as to possible ovaria...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198307000-00039
更新日期:1983-07-01 00:00:00
abstract::While in most states information physicians obtain from the about patients is confidential and cannot be disclosed without the patient's permission, a recent California Supreme Court decision affirms that when the doctor reasonably believes his patient can cause violent harm to third persons, he had an overriding duty...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197903000-00030
更新日期:1979-03-01 00:00:00
abstract::Whereas painless gross hematuria in the hemophiliac is usually secondary to the basic coagulation defect, it is not always so. An elderly man presented with this clinical situation which, after a protracted course, was ultimately proven to be associated with an infarcted kidney. In retrospect, the patient's age and th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198207000-00029
更新日期:1982-07-01 00:00:00
abstract::A 46-year-old woman had features of acute pulmonary edema soon after taking hydrochlorothiazide (HCTZ) for the first time. Although 31 cases of HCTZ-induced pulmonary edema have been reported in the world literature since it was first described in 1968, little is known about this clinical entity. Because its presence ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199911000-00013
更新日期:1999-11-01 00:00:00
abstract::Reported is the fifth known case of Addison's disease due to adrenal involvement by North American blastomycosis (Blastomyces dermatitidis infection). The fact that amphotericin B therapy precipitated an addisonian crisis suggests that patients with disseminated blastomycosis should have their adrenal function and res...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197707000-00028
更新日期:1977-07-01 00:00:00
abstract::We have described a patient with vaccinia necrosum after smallpox vaccination for persistent herpes labialis. The patient eventually recovered after surgical resection of the lesion and multiple courses of vaccinia immune globulin and methisazone. This report emphasizes the needless risks of vaccinating patients with ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198103000-00044
更新日期:1981-03-01 00:00:00
abstract::Thirty-two patients with a resectable mass in the head of the pancreas had pancreaticoduodenectomy for suspected or proven cancer. Twenty-eight proved to have cancer (15 periampullary and 13 pancreatic), and four had pancreatitis. The five-year survival for periampullary and pancreatic cancer was 25% and 0%, respectiv...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198509000-00007
更新日期:1985-09-01 00:00:00
abstract::Nontyphoidal salmonellae (NTS) are often isolated from stool specimens of individuals having evaluation of gastroenteritis. The significance of isolation of NTS in a stool specimen from previously healthy individuals with gastroenteritis is not clear. The purpose of this study was to determine which serotypes were bei...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199508000-00009
更新日期:1995-08-01 00:00:00
abstract::Atopic dermatitis (AD) is a common diagnosis seen in both children and adults, and it is often the first manifestation of atopic disease. Research has shown a strong correlation between serum IgE levels, the severity of atopic dermatitis, and co-existing asthma and/or allergic rhinitis. Omalizumab (Xolair, East Hanove...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181de0cf6
更新日期:2010-06-01 00:00:00
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journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199504000-00014
更新日期:1995-04-01 00:00:00
abstract::We retrospectively reviewed medical records and computerized critical care data for 40 consecutive critically ill surgical patients receiving "standard" doses (1.5 to 2.0 mg/kg loading dose and 3 to 5 mg/kg/day) of gentamicin or tobramycin for gram-negative infections. End points measured were serum drug levels and cl...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199701000-00007
更新日期:1997-01-01 00:00:00
abstract::A previously healthy 38-year-old man was stung multiple times by yellow jackets without any signs of anaphylaxis being observed. An electrocardiogram taken 16 hours later revealed episodes of wandering atrial pacemaker, junctional rhythm, and intermittent premature ventricular contractions. These arrhythmias disappear...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197904000-00030
更新日期:1979-04-01 00:00:00
abstract::This report describes a case of warm-antibody-mediated hemolytic anemia associated with a hypernephroma. Only four patients with renal cell carcinoma and Coombs'-positive hemolytic anemia have been reported previously. Although rare, the occurrence of autoimmune hemolytic anemia in association with a hypernephroma sho...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198509000-00023
更新日期:1985-09-01 00:00:00
abstract::Cirrhosis affects millions of people around the world and is associated with increased morbidity and mortality. Spontaneous bacterial peritonitis (SBP) is a common complication of liver disease with cirrhosis and accounts for up to 30% of infections in patients with cirrhosis. Patients with a history of SBP and those ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.14423/SMJ.0000000000000887
更新日期:2018-11-01 00:00:00