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Noninvasive evaluation of the effect of timolol on left ventricular performance after myocardial infarction and the consequence for prognosis.

Abstract：

:Left ventricular performance was evaluated noninvasively in 111 patients participating at one study center in the Norwegian Multicenter Study on Timolol After Myocardial Infarction. Systolic time intervals were measured in 55 patients treated with timolol and in 56 patients receiving placebo. Measurements were made before randomization, and after 1, 3 and 12 months of treatment. During the treatment period, the pre-ejection period/left ventricular ejection time ratio was significantly lower in the timolol-treated group, indicating better left ventricular function than in the placebo-treated patients. In the 27 patients who died during the follow-up period of 50 to 72 months, there was a significant increase in the pre-ejection period/left ventricular ejection time ratio from baseline to the last performed recording, indicating a deterioration in left ventricular performance in these patients. No such change occurred in the group that survived the entire follow-up period. Deterioration of left ventricular function is related to a high long-term mortality rate after myocardial infarction, and left ventricular function is better preserved in patients treated with timolol than in patients receiving placebo.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Brubakk O,Pedersen TR,Overskeid K

doi

10.1016/s0735-1097(87)80094-3

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

155-60

issue

1

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(87)80094-3

journal_volume

9

pub_type

临床试验,杂志文章,随机对照试验

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