Abstract:
:Signal-averaged electrocardiograms (ECGs) and programmed ventricular stimulation were serially performed in 12 dogs (3 weeks of age) after experimental anteroapical myocardial infarction. At electrophysiologic study, sustained ventricular tachyarrhythmia was induced in seven dogs on at least one occasion. Of a total of 39 electrophysiologic studies, sustained monomorphic ventricular tachycardia was induced in seven studies and ventricular fibrillation in eight studies. In the remaining studies, no ventricular arrhythmia could be induced with triple ventricular extrastimuli. There was considerable day to day variability in the response to programmed stimulation and the results of the signal-averaged ECG. The signal-averaged QRS complex was significantly longer in dogs with inducible ventricular tachycardia or fibrillation (61 +/- 5 versus 57 +/- 3 ms, p = 0.02), had a lower terminal QRS amplitude (24 +/- 20 versus 46 +/- 33 microV, p = 0.04) and a longer late potential duration (19 +/- 4 versus 15 +/- 3 ms, p = 0.003) compared with that in animals with no inducible ventricular arrhythmia. Late potentials were defined as a total QRS duration greater than 58 ms, a terminal QRS amplitude less than 20 microV and a late potential duration greater than 18 ms. Using this definition, late potentials were seen in two distinct phases--immediately after coronary ligation and then beyond the first 72 h after infarction. The appearance of late potentials coincided with a change in arrhythmia inducibility from no ventricular arrhythmia to initiation of sustained monomorphic ventricular tachycardia. There is a close relation between inducibility of ventricular tachycardia in experimental canine myocardial infarction and the appearance of late potentials on the surface ECG.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Kuchar DL,Rosenbaum DS,Ruskin J,Garan Hdoi
10.1016/s0735-1097(10)80027-0subject
Has Abstractpub_date
1990-05-01 00:00:00pages
1365-73issue
6eissn
0735-1097issn
1558-3597pii
S0735-1097(10)80027-0journal_volume
15pub_type
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journal_title:Journal of the American College of Cardiology
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更新日期:2011-07-05 00:00:00
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更新日期:2010-07-27 00:00:00
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更新日期:2006-02-07 00:00:00
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更新日期:2019-04-30 00:00:00
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更新日期:1991-05-01 00:00:00
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更新日期:2018-08-21 00:00:00
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更新日期:2006-11-21 00:00:00
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更新日期:2016-05-17 00:00:00
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更新日期:2000-12-01 00:00:00
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更新日期:2008-01-01 00:00:00
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更新日期:2013-06-04 00:00:00