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Chinese adults are less susceptible than whites to age-related endothelial dysfunction.

Abstract：

OBJECTIVES:We sought to assess the effects of aging on the endothelial physiology of a group of Chinese adults. BACKGROUND:Several studies have documented an association between aging and progressive arterial endothelial dysfunction in white subjects. We hypothesized that age-related endothelial dysfunction, an important event in atherosclerosis, might be less marked in southern Chinese subjects, in whom the prevalence of coronary heart disease is only approximately 20% of that in industrialized countries. METHODS:We studied endothelial function in 76 healthy adults aged 16 to 70 years: 38 Chinese from a village of 3,000 people in southern China and 38 white subjects from Sydney, Australia. In each ethnic group, there were 19 younger persons (16 to 40 years) and 19 older adults (55 to 70 years). None had evidence of diabetes, hypertension or clinical vascular disease or had ever been regular cigarette smokers. With the use of high resolution external vascular ultrasound, brachial artery diameter was measured at rest, after flow increase (causing endothelium-dependent dilation) and after sublingual nitroglycerin (an endothelium-independent dilator). RESULTS:Endothelium-dependent dilation was similar in young Chinese (mean +/- SD 8.3 +/- 2.5%), young whites (7.9 +/- 2.0%) and older Chinese (6.8 +/- 2.9%), but it was significantly impaired in older whites (1.8 +/- 2.5%, p < 0.001 by analysis of variance). On multivariate analysis, older age was associated with impaired endothelium-dependent dilation (p < 0.001) (independent of the effects of serum cholesterol, gender and vessel size) in the white but not in the Chinese subjects (p = 0.83). Nitroglycerin-induced dilation was not significantly different with aging in either ethnic group. CONCLUSIONS:Endothelium-dependent dilation is similar in the arteries of healthy young Chinese and white adults. With older age, however, Chinese subjects are less susceptible to impaired endothelial function.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Woo KS,McCrohon JA,Chook P,Adams MR,Robinson JT,McCredie RJ,Lam CW,Feng JZ,Celermajer DS

doi

10.1016/s0735-1097(97)00111-3

subject

Has Abstract

pub_date

1997-07-01 00:00:00

pages

113-8

issue

eissn

0735-1097

issn

1558-3597

pii

S0735109797001113

journal_volume

pub_type

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Chinese adults are less susceptible than whites to age-related endothelial dysfunction.