Abstract:
:To examine whether cardiopulmonary receptors participate in the reflex control of coronary vascular resistance, systemic and coronary hemodynamics were assessed before and during -10 mm Hg lower body negative pressure in eight normal subjects and eight hypertensive patients with left ventricular hypertrophy. In both study groups, lower body negative pressure induced a significant decrease in right atrial pressure, left ventricular filling pressure and cardiac output, an increase in systemic vascular resistance and no change in mean arterial pressure and heart rate. In normal subjects, there was also a significant increase in plasma norepinephrine concentration (from 294 +/- 39 to 421 +/- 47 pg/ml, p less than 0.01). This increase was accompanied by a reduction in coronary blood flow, assessed by the continuous thermodilution method (from 101 +/- 5 to 79 +/- 4 ml/min, p less than 0.05). An increase in coronary vascular resistance (from 0.865 +/- 0.1 to 1.107 +/- 0.1 mm Hg/ml per min, p less than 0.05) and in myocardial oxygen consumption was detected in normal subjects during cardiopulmonary baroreceptor unloading. In contrast, in hypertensive patients, -10 mm Hg lower body negative pressure failed to induce any change in plasma norepinephrine, coronary blood flow or vascular resistance. Intravenous propranolol administration caused no significant change in the systemic hemodynamic response to -10 mm Hg lower body negative pressure in either study group, but it did abolish the decrease in coronary flow and the increase in plasma norepinephrine, coronary vascular resistance and myocardial oxygen consumption observed in normal subjects in control conditions.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Trimarco B,Vigorito C,Cuocolo A,Ricciardelli B,De Luca N,Volpe M,Lembo G,Condorelli Mdoi
10.1016/s0735-1097(98)90050-xsubject
Has Abstractpub_date
1988-05-01 00:00:00pages
944-52issue
5eissn
0735-1097issn
1558-3597pii
S0735-1097(98)90050-Xjournal_volume
11pub_type
杂志文章abstract:OBJECTIVES:The aim of our study was to evaluate arterial embolism (AE) occurrence rates and predictors in patients suffering from bradycardia and wearing a pacemaker with antitachycardia pacing therapies. BACKGROUND:Atrial fibrillation (AF) is associated with a high incidence of AE. METHODS:A total of 725 patients (3...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jacc.2005.07.044
更新日期:2005-11-15 00:00:00
abstract:OBJECTIVES:This study sought to measure myocardial blood flow at rest and during dobutamine infusion and to correlate flow with cardiac work and severity of coronary artery disease. BACKGROUND:Dobutamine is used with cardiac imaging to induce possible ischemia in patients with known or suspected coronary artery diseas...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/0735-1097(96)00205-7
更新日期:1996-09-01 00:00:00
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doi:10.1016/s0735-1097(00)00703-8
更新日期:2000-07-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jacc.2004.08.070
更新日期:2005-09-20 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/0735-1097(89)90323-9
更新日期:1989-05-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:2020-09-29 00:00:00
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更新日期:2013-09-03 00:00:00
abstract:OBJECTIVES:The objective of this study was to determine the frequency of pulmonary complications, feasibility of early hospital discharge and requirements for postoperative inotropic and chronotropic support in patients receiving amiodarone therapy before heart transplantation. BACKGROUND:Although many patients waitin...
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pub_type: 临床试验,杂志文章
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更新日期:1992-12-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1987-02-01 00:00:00
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更新日期:1991-04-01 00:00:00
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更新日期:1992-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-10-09 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-11-03 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/s0735-1097(96)00583-9
更新日期:1997-03-15 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1999-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2018-01-30 00:00:00
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更新日期:2013-04-23 00:00:00
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更新日期:2005-01-04 00:00:00
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更新日期:1997-12-01 00:00:00
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更新日期:1990-08-01 00:00:00
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更新日期:1991-05-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2012-05-08 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:2020-11-10 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
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更新日期:1986-07-01 00:00:00
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更新日期:1998-08-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1996-09-01 00:00:00
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更新日期:2012-01-31 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
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更新日期:1995-10-01 00:00:00
abstract:OBJECTIVES:To compare seven-year survival in the Bypass Angioplasty Revascularization Investigation (BARI) patients randomly assigned to percutaneous transluminal coronary angioplasty (PTCA) versus coronary artery bypass grafting (CABG). BACKGROUND:The primary results of BARI reported no significant difference in five...
journal_title:Journal of the American College of Cardiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2000-04-01 00:00:00