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Percutaneous coronary laser balloon angioplasty: initial results of a multicenter experience.

Abstract：

:A multicenter clinical trial was initiated to test the potential safety and short-term efficacy of a percutaneous coronary application of laser balloon angioplasty, which has been shown experimentally to alleviate the common causes (dissection, recoil, thrombus) of suboptimal luminal results of conventional balloon angioplasty. Fifty-five patients, the majority (62%) of whom had relatively high risk lesions, were treated in 10 centers with a laser balloon that was identical in size (3 x 20 mm) to a balloon used for conventional balloon angioplasty performed on the same lesion immediately before laser balloon angioplasty. One or more neodymium:yttrium aluminum garnet (Nd:YAG) (1,060 nm) laser doses of 250 to 450 J were each delivered over a 20 s duration per exposure. Immediately and 1 day after laser balloon angioplasty no significant adverse effects on the arterial lumen were noted in any patient. By computerized image analysis of cineangiograms initial conventional balloon angioplasty failed to achieve a minimal luminal diameter greater than 1.5 mm in 14 patients (25%), including 3 patients with acute closure. However, after subsequent laser balloon angioplasty, minimal luminal diameter exceeded this value in all patients including this subgroup. Overall, minimal luminal diameter increased from 1.74 +/- 0.46 mm after conventional balloon angioplasty to 2.32 +/- 0.31 mm after laser balloon angioplasty (p less than 0.001) with no change found on 1 day and 1 month follow-up angiograms. Thus, laser balloon angioplasty is a safe, effective procedure for improving luminal dimensions after conventional balloon angioplasty.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Spears JR,Reyes VP,Wynne J,Fromm BS,Sinofsky EL,Andrus S,Sinclair IN,Hopkins BE,Schwartz L,Aldridge HE

doi

10.1016/0735-1097(90)90576-b

subject

Has Abstract,Author List Incomplete

pub_date

1990-08-01 00:00:00

pages

293-303

issue

2

eissn

0735-1097

issn

1558-3597

pii

0735-1097(90)90576-B

journal_volume

16

pub_type

临床试验,杂志文章,多中心研究

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