当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Colchicine treatment for the prevention of bare-metal stent restenosis in diabetic patients.

Colchicine treatment for the prevention of bare-metal stent restenosis in diabetic patients.

Abstract：

OBJECTIVES:This study sought to test the hypothesis that colchicine treatment after percutaneous coronary intervention (PCI) can lead to a decrease in in-stent restenosis (ISR). BACKGROUND:ISR rates are particularly high in certain patient subsets, including diabetic patients, especially when a bare-metal stent (BMS) is used. Pharmacological interventions to decrease ISR could be of clinical relevance. METHODS:Diabetic patients with contraindication to a drug-eluting stent, undergoing PCI with a BMS, were randomized to receive colchicine 0.5 mg twice daily or placebo for 6 months. Restenosis and neointima formation were studied with angiography and intravascular ultrasound 6 months after the index PCI. RESULTS:A total of 196 patients (63.6 ± 7.0 years of age, 128 male) were available for analysis. The angiographic ISR rate was 16% in the colchicine group and 33% in the control group (p = 0.007; odds ratio: 0.38, 95% confidence interval: 0.18 to 0.79). The number needed to treat to avoid 1 case of angiographic ISR was 6 (95% confidence interval: 3.4 to 18.7). The results were similar for IVUS-defined ISR (odds ratio: 0.42; 95% confidence interval: 0.22 to 0.81; number needed to treat = 5). Lumen area loss was 1.6 mm(2) (interquartile range: 1.0 to 2.9 mm(2)) in colchicine-treated patients and 2.9 mm(2) (interquartile range: 1.4 to 4.8 mm(2)) in the control group (p = 0.002). Treatment-related adverse events were largely limited to gastrointestinal symptoms. CONCLUSIONS:Colchicine is associated with less neointimal hyperplasia and a decreased ISR rate when administered to diabetic patients after PCI with a BMS. This observation may prove useful in patients undergoing PCI in whom implantation of a drug-eluting stent is contraindicated or undesirable.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Deftereos S,Giannopoulos G,Raisakis K,Kossyvakis C,Kaoukis A,Panagopoulou V,Driva M,Hahalis G,Pyrgakis V,Alexopoulos D,Manolis AS,Stefanadis C,Cleman MW

doi

10.1016/j.jacc.2013.01.055

subject

Has Abstract

pub_date

2013-04-23 00:00:00

pages

1679-85

issue

16

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(13)00696-7

journal_volume

61

pub_type

杂志文章,随机对照试验

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Myocardial viability in chronic ischemic heart disease: comparison of contrast-enhanced magnetic resonance imaging with (18)F-fluorodeoxyglucose positron emission tomography.

    abstract：OBJECTIVES:We sought to compare contrast-enhanced magnetic resonance imaging (ceMRI) with nuclear metabolic imaging for the assessment of myocardial viability in patients with chronic ischemic heart disease and left ventricular (LV) dysfunction. BACKGROUND:Contrast-enhanced MRI has been shown to identify scar tissue i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(03)00158-x

    authors： Kühl HP,Beek AM,van der Weerdt AP,Hofman MB,Visser CA,Lammertsma AA,Heussen N,Visser FC,van Rossum AC

    更新日期：2003-04-16 00:00:00

  • Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization.

    abstract：OBJECTIVES:The purpose of this study was to examine the effects of glycoprotein (GP) IIb/IIIa antagonists (abciximab, eptifibatide, and tirofiban) and other inhibitors on translocation of CD40L from intraplatelet stores to the platelet surface and on the release of soluble CD40L (sCD40L) from platelets. BACKGROUND:CD4...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2003.12.055

    authors： Furman MI,Krueger LA,Linden MD,Barnard MR,Frelinger AL 3rd,Michelson AD

    更新日期：2004-06-16 00:00:00

  • Effects of antiarrhythmic drugs on canine atrial flutter due to reentry: role of prolongation of refractory period and depression of conduction to excitable gap.

    abstract：:Antiarrhythmic drugs prolong the effective refractory period and depress conduction. To determine the exact role played by these two electrophysiologic effects in the termination of reentry, the effects of disopyramide, flecainide, propafenone and E-4031, a new class III drug, were examined in a canine model of atrial...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90773-3

    authors： Inoue H,Yamashita T,Nozaki A,Sugimoto T

    更新日期：1991-10-01 00:00:00

  • Plasmin inhibitors in the prevention of systemic effects during thrombolytic therapy: specific role of the plasminogen-binding form of alpha 2-antiplasmin.

    abstract：:To delineate the role of plasmin inhibitors, especially the two molecular forms of alpha 2-antiplasmin (that is, the plasminogen-binding and the nonplasminogen-binding forms), in the control of systemic effects during thrombolytic therapy, the consumption of plasmin inhibitors and the degree of fibrinogen breakdown we...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(10)80003-8

    authors： Leebeek FW,Kluft C,Knot EA,Los P,Cohen AF,Six AJ

    更新日期：1990-05-01 00:00:00

  • Application of evidence-based medical therapy is associated with improved outcomes after percutaneous coronary intervention and is a valid quality indicator.

    abstract：OBJECTIVES:We sought to determine whether the prescription of evidence-based medications at discharge after successful percutaneous coronary intervention (PCI) can predict long-term clinical outcome. BACKGROUND:The association of standard-of-care drug utilization and long-term mortality and morbidity after PCI is not ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.06.070

    authors： Jaber WA,Lennon RJ,Mathew V,Holmes DR Jr,Lerman A,Rihal CS

    更新日期：2005-10-18 00:00:00

  • Smokeless tobacco as a possible risk factor for myocardial infarction: a population-based study in middle-aged men.

    abstract：OBJECTIVES:To explore whether the use of snuff affects the risk of myocardial infarction (MI). BACKGROUND:Snuff and other forms of smokeless tobacco are widely used in some populations. Possible health hazards associated with the use of smokeless tobacco remain controversial. METHODS:In a population-based study withi...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00409-x

    authors： Huhtasaari F,Lundberg V,Eliasson M,Janlert U,Asplund K

    更新日期：1999-11-15 00:00:00

  • Effects of paroxetine hydrochloride, a selective serotonin reuptake inhibitor, on refractory vasovagal syncope: a randomized, double-blind, placebo-controlled study.

    abstract：OBJECTIVES:The purpose of the study was to determine whether the well tolerated serotonin reuptake inhibitor paroxetine hydrochloride could prevent vasovagal syncope in patients resistant to or intolerant of previous traditional therapies. BACKGROUND:Serotonergic mechanisms play a major role in the processes leading t...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0735-1097(98)00694-9

    authors： Di Girolamo E,Di Iorio C,Sabatini P,Leonzio L,Barbone C,Barsotti A

    更新日期：1999-04-01 00:00:00

  • Significant mitral regurgitation left untreated at the time of aortic valve replacement: a comprehensive review of a frequent entity in the transcatheter aortic valve replacement era.

    abstract：:Significant mitral regurgitation (MR) is frequent in patients with severe aortic stenosis (AS). In these cases, concomitant mitral valve repair or replacement is usually performed at the time of surgical aortic valve replacement (SAVR). Transcatheter aortic valve replacement (TAVR) has recently been considered as an a...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2014.02.573

    authors： Nombela-Franco L,Ribeiro HB,Urena M,Allende R,Amat-Santos I,DeLarochellière R,Dumont E,Doyle D,DeLarochellière H,Laflamme J,Laflamme L,García E,Macaya C,Jiménez-Quevedo P,Côté M,Bergeron S,Beaudoin J,Pibarot P,Rodés-C

    更新日期：2014-06-24 00:00:00

  • Importance of ablating all potential right atrial flutter circuits in postcardiac surgery patients.

    abstract：OBJECTIVES:In patients with atrial flutter (AFL) and postoperative right atrial incisional scars, we sought to assess if the use of additional ablative lesions that targeted all potential re-entrant circuits, regardless of the presenting type of flutter, would prevent long-term recurrence. BACKGROUND:Patients with AFL...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2004.04.045

    authors： Verma A,Marrouche NF,Seshadri N,Schweikert RA,Bhargava M,Burkhardt JD,Kilicaslan F,Cummings J,Saliba W,Natale A

    更新日期：2004-07-21 00:00:00

  • Endothelin receptor antagonists in pulmonary arterial hypertension.

    abstract：:Endothelin receptor antagonism has emerged as an important therapeutic strategy in pulmonary arterial hypertension (PAH). Laboratory and clinical investigations have clearly shown that endothelin (ET)-1 is overexpressed in several forms of pulmonary vascular disease and likely plays a significant pathogenetic role in ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2004.02.042

    authors： Channick RN,Sitbon O,Barst RJ,Manes A,Rubin LJ

    更新日期：2004-06-16 00:00:00

  • Vorapaxar in acute coronary syndrome patients undergoing coronary artery bypass graft surgery: subgroup analysis from the TRACER trial (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome).

    abstract：OBJECTIVES:This study evaluated effects of protease-activated receptor-1 antagonist vorapaxar (Merck, Whitehouse Station, New Jersey) versus placebo among the TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) study patients with non-ST-segment elevation acute coronary syndrom...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jacc.2013.10.048

    authors： Whellan DJ,Tricoci P,Chen E,Huang Z,Leibowitz D,Vranckx P,Marhefka GD,Held C,Nicolau JC,Storey RF,Ruzyllo W,Huber K,Sinnaeve P,Weiss AT,Dery JP,Moliterno DJ,Van de Werf F,Aylward PE,White HD,Armstrong PW,Wallentin

    更新日期：2014-03-25 00:00:00

  • Correlation among right ventricular preload, afterload and ejection fraction in mitral valve disease: radionuclide, echocardiographic and hemodynamic evaluation.

    abstract：:The relation among right ventricular preload, afterload and ejection fraction in patients with mitral valve disease has not been well elucidated. In this study, measurements were made of intracardiac pressures and forward cardiac output during cardiac catheterization (n = 43), the ejection fraction by radionuclide ang...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(84)80278-8

    authors： Iskandrian AS,Hakki AH,Ren JF,Kotler MN,Mintz GS,Ross J,Kane SA

    更新日期：1984-06-01 00:00:00

  • Echocardiographic insights into the mechanisms of relief of left ventricular outflow tract obstruction after nonsurgical septal reduction therapy in patients with hypertrophic obstructive cardiomyopathy.

    abstract：OBJECTIVES:We sought to evaluate the mechanisms by which nonsurgical septal reduction therapy (NSRT) reduces left ventricular outflow tract (LVOT) obstruction in patients with hypertrophic obstructive cardiomyopathy (HOCM) both acutely and on a long-term basis. BACKGROUND:NSRT reduces LVOT obstruction in patients with...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)01045-7

    authors： Flores-Ramirez R,Lakkis NM,Middleton KJ,Killip D,Spencer WH 3rd,Nagueh SF

    更新日期：2001-01-01 00:00:00

  • The prevalence of coronary artery calcium among diabetic individuals without known coronary artery disease.

    abstract：OBJECTIVES:We sought to examine the age and gender distribution of coronary artery calcium (CAC) by diabetes status in a large cohort of asymptomatic individuals. BACKGROUND:Among individuals with diabetes, coronary artery disease (CAD) is a major cause of morbidity and mortality. Electron-beam tomography (EBT) quanti...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02975-3

    authors： Hoff JA,Quinn L,Sevrukov A,Lipton RB,Daviglus M,Garside DB,Ajmere NK,Gandhi S,Kondos GT

    更新日期：2003-03-19 00:00:00

  • Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.

    abstract：OBJECTIVES:This study investigated whether reduced levels of circulating endothelial progenitors cells (EPCs) in chronic heart failure (CHF) are secondary to an exhaustion of hematopoietic stem cells (HSCs) in the bone marrow or to reduced mobilization. BACKGROUND:Circulating EPCs presumably originate from bone marrow...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.01.095

    authors： Kissel CK,Lehmann R,Assmus B,Aicher A,Honold J,Fischer-Rasokat U,Heeschen C,Spyridopoulos I,Dimmeler S,Zeiher AM

    更新日期：2007-06-19 00:00:00

  • Alteration of left ventricular diastolic function during coronary angioplasty-induced ischemia: a color M-mode Doppler study.

    abstract：OBJECTIVES:The aim of this study was to assess the effects of ischemia on diastolic function by analyzing flow propagation velocity with color M-mode Doppler echocardigraphy. BACKGROUND:Color M-mode Doppler echocardiography has been proposed as a method of assessing left ventricular filling. METHODS:Color M-mode Dopp...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(97)00052-1

    authors： Duval-Moulin AM,Dupouy P,Brun P,Zhuang F,Pelle G,Perez Y,Teiger E,Castaigne A,Gueret P,Dubois-Randé JL

    更新日期：1997-05-01 00:00:00

  • Hemodynamic effects of nifedipine in primary pulmonary hypertension.

    abstract：:Progressive dyspnea and syncope occurred in a young woman with primary pulmonary hypertension despite therapy with hydralazine. Abnormal pulmonary artery reactivity was documented by an additional increase in pulmonary artery pressure and pulmonary vascular resistance during exercise and after an episode of hydralazin...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(83)80389-1

    authors： Douglas JS Jr

    更新日期：1983-07-01 00:00:00

  • Quality of care for atrial fibrillation among patients hospitalized for heart failure.

    abstract：OBJECTIVES:This study sought to examine quality of care and warfarin use at discharge in patients with atrial fibrillation (AF) and heart failure (HF). BACKGROUND:Atrial fibrillation is common in HF, and national guidelines recommend discharge on warfarin for stroke prophylaxis. However, the frequency and factors asso...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2009.04.091

    authors： Piccini JP,Hernandez AF,Zhao X,Patel MR,Lewis WR,Peterson ED,Fonarow GC,Get With The Guidelines Steering Committee and Hospitals.

    更新日期：2009-09-29 00:00:00

  • Late systolic click from isolated tricuspid valve prolapse simulating paradoxical splitting of the second heart sound.

    abstract：:A 72 year old woman was thought to have a paradoxically split second heart sound. Echocardiography with simultaneous phonocardiography revealed a late systolic click resulting from isolated tricuspid valve prolapse. Respiratory variation of the click in relation to the second heart sound resulted in an auscultatory ph...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80414-9

    authors： Farrar MW,Engel PJ,Eppert D,Plummer S

    更新日期：1985-03-01 00:00:00

  • Beta-blocker use and survival in patients with ventricular fibrillation or symptomatic ventricular tachycardia: the Antiarrhythmics Versus Implantable Defibrillators (AVID) trial.

    abstract：OBJECTIVES:To evaluate whether use of beta-adrenergic blocking agents, alone or in combination with specific antiarrhythmic therapy, is associated with improved survival in persons with ventricular fibrillation (VF) or symptomatic ventricular tachycardia (VT). BACKGROUND:The ability of beta-blockers to alter the morta...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0735-1097(99)00234-x

    authors： Exner DV,Reiffel JA,Epstein AE,Ledingham R,Reiter MJ,Yao Q,Duff HJ,Follmann D,Schron E,Greene HL,Carlson MD,Brodsky MA,Akiyama T,Baessler C,Anderson JL

    更新日期：1999-08-01 00:00:00

  • Implication of different cardiac troponin I levels for clinical outcomes and prognosis of acute chest pain patients.

    abstract：OBJECTIVES:We compared outcomes in patients with non-ST-segment elevation acute coronary syndromes (ACS) according to the degree of cardiac troponin I (cTnI) elevation. BACKGROUND:Controlled trials of high-risk patients have found that troponin elevations identify an even higher risk subset. It is unclear whether outc...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2003.10.036

    authors： Kontos MC,Shah R,Fritz LM,Anderson FP,Tatum JL,Ornato JP,Jesse RL

    更新日期：2004-03-17 00:00:00

  • Adverse consequences of high sympathetic nervous activity in the failing human heart.

    abstract：OBJECTIVES:In view of previous experimental evidence relating sympathetic nervous overactivity in the heart to myocardial necrosis and ventricular arrhythmias, we prospectively examined the hypothesis that heightened cardiac sympathetic nervous activity is associated with an adverse outcome in patients with moderate to...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00332-0

    authors： Kaye DM,Lefkovits J,Jennings GL,Bergin P,Broughton A,Esler MD

    更新日期：1995-11-01 00:00:00

  • Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation.

    abstract：OBJECTIVES:We examined whether mitral regurgitation (MR) augments post-myocardial infarction (MI) remodeling. BACKGROUND:MR doubles mortality after MI, but its additive contribution to left ventricular (LV) remodeling is debated and has not been addressed in a controlled fashion. METHODS:Apical MIs were created in 12...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.07.093

    authors： Beeri R,Yosefy C,Guerrero JL,Nesta F,Abedat S,Chaput M,del Monte F,Handschumacher MD,Stroud R,Sullivan S,Pugatsch T,Gilon D,Vlahakes GJ,Spinale FG,Hajjar RJ,Levine RA

    更新日期：2008-01-29 00:00:00

  • Remodeling of the aorta after successful balloon coarctation angioplasty.

    abstract：:The purpose of this study was to examine whether remodeling of the aorta takes place after successful balloon angioplasty of aortic coarctation. During the 35 month period ending in December 1987, 30 children, aged 14 days to 13 years, underwent balloon angioplasty of unoperated aortic coarctation, with a resultant re...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(89)90434-8

    authors： Rao PS,Carey P

    更新日期：1989-11-01 00:00:00

  • Asynchronous atrioventricular valve opening as it relates to right to left interatrial shunting in the normal newborn.

    abstract：:The opening of the tricuspid valve and the onset of right ventricular filling precede the opening of the mitral valve and the onset of flow in the normal adult. Sixty-five studies of atrioventricular flow with range-gated pulsed Doppler echocardiography, performed on 32 normal neonates, consistently demonstrated the r...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(88)80062-7

    authors： Steinfeld L,Almeida OD,Rothfeld EL

    更新日期：1988-09-01 00:00:00

  • Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study.

    abstract：OBJECTIVES:The purpose of this study was to analyze the incidence of new atrial fibrillation or flutter (AFF) in the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) database. BACKGROUND:Aldosterone antagonism in heart failure might influence atrial fibrosis and remodeling ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2011.11.063

    authors： Swedberg K,Zannad F,McMurray JJ,Krum H,van Veldhuisen DJ,Shi H,Vincent J,Pitt B,EMPHASIS-HF Study Investigators.

    更新日期：2012-05-01 00:00:00

  • Ventricular arrhythmia induced by sodium channel blocker in patients with Brugada syndrome.

    abstract：OBJECTIVES:We administered pilsicainide chloride, a class Ic pure sodium channel blocker, to patients with Brugada syndrome (BS) and evaluated the occurrence of ventricular arrhythmia (VA) and T-wave alternans (TWA). BACKGROUND:Ventricular arrhythmia and TWA are sometimes induced by a sodium channel blocker challenge ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2003.06.004

    authors： Morita H,Morita ST,Nagase S,Banba K,Nishii N,Tani Y,Watanabe A,Nakamura K,Kusano KF,Emori T,Matsubara H,Hina K,Kita T,Ohe T

    更新日期：2003-11-05 00:00:00

  • Pulse pressure amplification a mechanical biomarker of cardiovascular risk.

    abstract：OBJECTIVES:The aim of this study was to determine whether the carotid/brachial (C/B) ratio is an independent predictor of cardiovascular (CV) risk. BACKGROUND:Brachial and carotid pulse pressure (PP) are independent predictors of CV risk, mainly in elderly patients. Because PP is physiologically lower at the brachial ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2009.09.061

    authors： Benetos A,Thomas F,Joly L,Blacher J,Pannier B,Labat C,Salvi P,Smulyan H,Safar ME

    更新日期：2010-03-09 00:00:00

  • Echocardiographic-morphologic correlations in tricuspid atresia.

    abstract：OBJECTIVES:Our aim was to clarify the anatomic substrate in hearts diagnosed as having tricuspid atresia by studying autopsy specimens and comparing the findings with those in two-dimensional echocardiograms. BACKGROUND:Traditionally, tricuspid atresia was thought, and is still believed by some, to be due to an imperf...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00250-8

    authors： Orie JD,Anderson C,Ettedgui JA,Zuberbuhler JR,Anderson RH

    更新日期：1995-09-01 00:00:00

  • Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome.

    abstract：:Obstructive sleep apnea (OSA) is an underdiagnosed condition characterized by recurrent episodes of obstruction of the upper airway leading to sleep fragmentation and intermittent hypoxia during sleep. Obesity predisposes to OSA, and the prevalence of OSA is increasing worldwide because of the ongoing epidemic of obes...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2013.05.045

    authors： Drager LF,Togeiro SM,Polotsky VY,Lorenzi-Filho G

    更新日期：2013-08-13 00:00:00