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Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo.

Abstract：

OBJECTIVES:We investigated whether transmural mechanics could yield insight into the transmural electrical sequence. BACKGROUND:Although the concept of transmural dispersion of repolarization has helped explain a variety of arrhythmias, its presence in vivo is still disputable. METHODS:We studied the time course of transmural myofiber mechanics in the anterior left ventricle of normal canines in vivo (n = 14) using transmural bead markers under biplane cineradiography. In 4 of these animals, plunge electrodes were placed in the myocardial tissue within the bead set to measure transmural electrical sequence. RESULTS:The onset of myofiber shortening was earliest at endocardial layers and progressively delayed toward epicardial layers (p < 0.001), resulting in transmural dispersion of myofiber shortening of 39 ms. The onset of myofiber relaxation was earliest at epicardial layers and most delayed at subendocardial layers (p = 0.004), resulting in transmural dispersion of myofiber relaxation of 83 ms. There was no significant transmural gradient in electrical repolarization (p = NS). CONCLUSIONS:Despite lack of evidence of significant transmural gradient in electrical repolarization in vivo, there is transmural dispersion of myofiber relaxation as well as shortening.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Ashikaga H,Coppola BA,Hopenfeld B,Leifer ES,McVeigh ER,Omens JH

doi

10.1016/j.jacc.2006.07.074

subject

Has Abstract

pub_date

2007-02-27 00:00:00

pages

909-16

issue

8

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(06)03010-5

journal_volume

49

pub_type

杂志文章

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