Glomerular epithelial cell, polyanion neutralization is associated with enhanced prostanoid production.

abstract：BACKGROUND:Cold ischemia and reperfusion during kidney transplantation are associated with release of free oxygen radicals and damage of renal tubular cells. Bioflavonoids may diminish cold storage-induced injury due to antioxidant and iron chelating activities. This study was designed to delineate the renoprotective m...

journal_title：Kidney international

authors： Ahlenstiel T,Burkhardt G,Köhler H,Kuhlmann MK

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Strict glycemic control and antihypertensive treatment may decrease but not eliminate the risk of progressive nephropathy in diabetic patients. C-peptide has been shown to exert beneficial effects on complications, including incipient nephropathy, in type 1 diabetes. METHODS:Renal effects of 14 days of intr...

journal_title：Kidney international

authors： Samnegård B,Jacobson SH,Jaremko G,Johansson BL,Sjöquist M

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Clinical studies have shown that the angiotensin-converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor antagonists decrease proteinuria and slow the progression of nephropathy in diabetes, indicating that Ang II plays an important role in the development of nephropathy. We have previously re...

journal_title：Kidney international

authors： Zhang SL,Filep JG,Hohman TC,Tang SS,Ingelfinger JR,Chan JS

更新日期：1999-02-01 00:00:00

abstract：:Diabetes mellitus is associated with natriuresis, whereas estrogen has been shown to be renoprotective in diabetic nephropathy and may independently regulate renal sodium reabsorption. The aim of this study was to determine the effects of 17-beta estradiol (E(2)) replacement to diabetic, ovariectomized (OVX) female ra...

journal_title：Kidney international

authors： Riazi S,Maric C,Ecelbarger CA

更新日期：2006-02-01 00:00:00

abstract：:The neonatal proximal tubule has a lower rate of bicarbonate absorption than that of adults. This is due, in part, to a lower rate of apical membrane Na+/H+ antiporter activity. The purpose of these studies was to examine if thyroid hormone could be a factor in the maturational increase in Na+/H+ antiporter activity. ...

journal_title：Kidney international

authors： Baum M,Dwarakanath V,Alpern RJ,Moe OW

更新日期：1998-05-01 00:00:00

abstract：:Normal urine contains thousands of proteins, largely due to the presence of 'exosomes,' tiny vesicles secreted into the urine by renal epithelial cells. These exosomes, demonstrated by Keller and colleagues to be also retrievable from amniotic fluid, offer great promise for future disease biomarker discovery studies. ...

journal_title：Kidney international

authors： Knepper MA,Pisitkun T

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:The rat renal proximal tubule cells contain a large amount of monoamine oxidase, which catalyzes the oxidative deamination of catecholamines such as dopamine (DA). The aim of this study is to investigate the potential role of hydrogen peroxide (H2O2) produced by monoamine oxidase (MAO) isoform on regulation ...

journal_title：Kidney international

authors： Vindis C,Séguélas MH,Lanier S,Parini A,Cambon C

更新日期：2001-01-01 00:00:00

abstract：:This study examined the consequences of nephrectomy in United States Army personnel who lost a kidney due to trauma during World War II (WWII). Records of 62 servicemen who underwent nephrectomy at an average age of 25 years were obtained. Mortality was compared with that of WWII servicemen of the same age. Medical re...

journal_title：Kidney international

authors： Narkun-Burgess DM,Nolan CR,Norman JE,Page WF,Miller PL,Meyer TW

更新日期：1993-05-01 00:00:00

abstract：:Early kidney transplant results in children lagged behind corresponding results in adults. Multiple advances over the past three decades have eliminated that gap. Most children now have equal or superior long-term allograft and patient survival compared with adult recipients. However, black children in the United Stat...

journal_title：Kidney international

authors： Dharnidharka VR,Seifert ME

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:It is known that inhibition of cyclooxygenase (COX) impairs the renal actions of loop diuretics. Recently, we found that cyclosporine A (CsA) inhibits renal COX-2 expression. Therefore, we examined the interferences of CsA with the renal actions of loop diuretics. METHOD:We investigated the renal effects of...

journal_title：Kidney international

authors： Höcherl K,Kees F,Krämer BK,Kurtz A

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Torsemide has predictable absorption compared to furosemide. Thereby, torsemide results in more constant exposure to active drug. Our hypothesis was that this pharmacokinetic difference between these commonly used loop diuretics may translate into disparate antihypertensive responses in patients with chronic...

journal_title：Kidney international

authors： Vasavada N,Saha C,Agarwal R

更新日期：2003-08-01 00:00:00

abstract：:Polycystic renal disease was induced in rats by feeding 2-amino-4,5-diphenylthiazole. Tubular (TBM) and glomerular basement membranes (GBM) were purified and analyzed for possible structural changes that may be a factor in the development of the tubular dilations and cysts. Changes in the relative quantities of TBM po...

journal_title：Kidney international

authors： Butkowski RJ,Carone FA,Grantham JJ,Hudson BG

更新日期：1985-11-01 00:00:00

abstract：:The monoclonal antibody (mAb) 3G5 was found, by indirect immunofluorescence, to bind to renal cortical structures in frozen sections of human, rat and calf kidneys. Double indirect immunofluorescence studies on frozen sections of rat kidneys showed that 3G5 stained only the glomerulus and the distribution of the 3G5 a...

journal_title：Kidney international

authors： Nayak RC,Attawia MA,Cahill CJ,King GL,Ohashi H,Moromisato R

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Hyperphagic obese Zucker rats develop glomerular injury and die of renal disease, an outcome prevented by food restriction at an early age. We examined the effects of food restriction imposed at different ages on systemic, renal hemodynamic, and hormonal changes to gain insight into the mechanisms of obesity...

journal_title：Kidney international

authors： Maddox DA,Alavi FK,Santella RN,Zawada ET Jr

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Arteriovenous (AV) fistulas used for hemodialysis access may affect cardiac load by increasing the preload while decreasing the afterload. In dogs, AV fistulas have also been shown to affect coronary perfusion negatively. We investigated the net effect of AV fistulas on cardiac oxygen supply and demand. MET...

journal_title：Kidney international

authors： Bos WJ,Zietse R,Wesseling KH,Westerhof N

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:To identify susceptibility genes for diabetic nephropathy, GeneChip Expression Analysis was employed to survey the gene expression profile of diabetic KK/Ta mouse kidneys. METHODS:Kidneys from three KK/Ta and two BALB/c mice at 20 weeks of age were dissected. Total RNA was extracted and labeled for hybridiz...

journal_title：Kidney international

authors： Fan Q,Shike T,Shigihara T,Tanimoto M,Gohda T,Makita Y,Wang LN,Horikoshi S,Tomino Y

更新日期：2003-12-01 00:00:00

abstract：:Disturbed pulsatile LH secretion has been suggested to play a role in the etiology of delayed puberty and disturbed reproductive function in chronic renal failure (CRF), but interpretation of gonadotropin secretion from plasma concentration measurements is confounded by alterations in hormone metabolic clearance. To s...

journal_title：Kidney international

authors： Schaefer F,Veldhuis JD,Robertson WR,Dunger D,Schärer K

更新日期：1994-05-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a key cause of hypertension and a potent independent risk for cardiovascular disease. Epidemiological studies suggest a strong genetic component determining susceptibility for renal disease and, by inference, the associated cardiovascular risk. With a subtotal nephrectomy model of kidne...

journal_title：Kidney international

authors： Salzler HR,Griffiths R,Ruiz P,Chi L,Frey C,Marchuk DA,Rockman HA,Le TH

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:The use of renal Kt/V (r-Kt/V) as an indicator for the need of dialysis initiation has been recommended in the NKF-DOQI guidelines. In analogy to clinical practice in peritoneal dialysis, a fall of r-Kt/V below a threshold of 2.0 per week may indicate inadequate renal toxin elimination. However, there are no...

journal_title：Kidney international

authors： Kuhlmann MK,Heckmann M,Riegel W,Köhler H

更新日期：2001-10-01 00:00:00

abstract：:This study evaluated risk factors for end-stage renal disease (ESRD) and the prognostic significance of serum creatinine levels in a community-based mass screening. We used the registries of both community-based mass screening and chronic dialysis programs. In 1983, a total of 107,192 subjects over 18 years of age (51...

journal_title：Kidney international

authors： Iseki K,Ikemiya Y,Fukiyama K

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:The growth hormone (GH)/insulin-like growth factor (IGF) system is thought to participate in the glomerulosclerosis process. Because IGF-binding proteins (IGFBPs) modulate IGF actions and hence GH secretion, this study assessed whether mice transgenic for human IGFBP-1 have altered susceptibility to glomerul...

journal_title：Kidney international

authors： Doublier S,Seurin D,Fouqueray B,Verpont MC,Callard P,Striker LJ,Striker GE,Binoux M,Baud L

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:The glomerular podocyte is the kidney cell most affected during the development of nephrotic syndrome, and mutations in podocyte proteins are responsible for a variety of inherited forms of nephrotic syndrome. Although glucocorticoids are a primary treatment for nephrotic syndrome, neither their target cell ...

journal_title：Kidney international

authors： Ransom RF,Vega-Warner V,Smoyer WE,Klein J

更新日期：2005-04-01 00:00:00

abstract：:This study offers morphological evidence of the involvement of lipid abnormalities in human glomerular injury. Renal biopsy tissues from patients with several types of glomerular diseases were immunocytochemically examined using antibodies to apolipoproteins (apo) A-I, B-100, and E, and antibodies to low density lipop...

journal_title：Kidney international

authors： Takemura T,Yoshioka K,Aya N,Murakami K,Matumoto A,Itakura H,Kodama T,Suzuki H,Maki S

更新日期：1993-04-01 00:00:00

abstract：:The existence of a tissue renin-angiotensin (RAS) system independent of the circulating RAS has prompted the search for cellular binding sites for angiotensinogen and for renin in order to explain their tissue uptake. Two receptors that bind with similar affinity mature renin and prorenin were identified, the mannose-...

journal_title：Kidney international

authors： Nguyen G

更新日期：2006-05-01 00:00:00

abstract：:Activation of cAMP signaling pathway was shown to inhibit some pathobiologic processes in mesangial cells (MC). We investigated whether adrenomedullin (ADM), a potent agonist of adenylate cyclase, is synthesized in MC and whether it can, via cAMP, suppress the generation of reactive oxygen metabolites (ROM) and prolif...

journal_title：Kidney international

authors： Chini EN,Chini CC,Bolliger C,Jougasaki M,Grande JP,Burnett JC Jr,Dousa TP

更新日期：1997-10-01 00:00:00

abstract：:To investigate whether the administration of cimetidine can improve the reliability of creatinine as a marker of GFR, we compared the creatinine clearance (CCr) to the clearance of the true filtration markers 51Cr-EDTA (CEDTA) and inulin (CIn), after oral ingestion of cimetidine in 10 healthy men and 29 patients with ...

journal_title：Kidney international

authors： Hilbrands LB,Artz MA,Wetzels JF,Koene RA

更新日期：1991-12-01 00:00:00

abstract：:Long-term complications of continuous immunosuppression still remain a serious threat and are currently drawing the attention of transplant physicians. Wimmer et al. show that malignancy occurs approximately fourfold more frequently in renal-transplant recipients than in a normal control population. Besides immunosupp...

journal_title：Kidney international

authors： Bosmans JL,Verpooten GA

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Random, nontimed blood pressure (BP) measurements in the outpatient clinic may fail to provide reliable information on actual daily BP control in renal patients on chronic antihypertensive therapy. METHODS:In a cohort of 163 patients with proteinuric chronic nephropathies followed prospectively with repeate...

journal_title：Kidney international

authors： Ruggenenti P,Perna A,Lesti M,Pisoni R,Mosconi L,Arnoldi F,Ciocca I,Gaspari F,Remuzzi G

更新日期：2000-11-01 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (Ngal, 24p3, SIP24, lipocalin 2, or siderocalin) was originally purified from neutrophils, but with unknown function. Recently, it was identified that Ngal activates nephron formation in the embryonic kidney, is rapidly and massively induced in renal failure and possesses kid...

journal_title：Kidney international

authors： Mori K,Nakao K

更新日期：2007-05-01 00:00:00

abstract：:The hypercalcemia of malignancy is mediated by complex and heterogeneous mechanisms. Once thought of as a simple paraneoplastic syndrome mediated by the effects of tumor production of PTH, it is now clear that multiple mechanisms are involved and that these mechanisms involve abnormalities in calcium transport in bone...

journal_title：Kidney international

authors： Mundy GR

更新日期：1987-01-01 00:00:00