Abstract:
INTRODUCTION:Amyloidosis derived from transthyretin (TTR) molecules is typically caused by mutations of the TTR gene. METHODS:We describe an elderly patient with a severe length-dependent polyneuropathy that unexpectedly proved to be caused by wild-type transthyretin amyloidosis. RESULTS:The diagnosis was made by muscle biopsy, because no amyloid deposits were found in the biopsied nerve segment. Most cases of wild-type transthyretin amyloidosis occur in elderly patients with cardiomyopathy, but a few cases of polyneuropathy have been reported. CONCLUSIONS:This entity is especially noteworthy in light of emerging treatment options for hereditary transthyretin amyloidosis, which are likely to also be beneficial in wild-type disease.
journal_name
Muscle Nervejournal_title
Muscle & nerveauthors
Lam L,Margeta M,Layzer Rdoi
10.1002/mus.24563subject
Has Abstractpub_date
2015-07-01 00:00:00pages
146-9issue
1eissn
0148-639Xissn
1097-4598journal_volume
52pub_type
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