Urinary metabolites of caffeine in the premature infant.

abstract：:Eighty patients recovering from major operations were investigated to evaluate the influence of naloxone on the analgesic and respiratory depressant properties of buprenorphine. They were randomly assigned to two groups to self-administer either buprenorphine (Group B) or a mixture of buprenorphine and naloxone (fract...

journal_title：European journal of clinical pharmacology

authors： Lehmann KA,Reichling U,Wirtz R

更新日期：1988-01-01 00:00:00

abstract：:Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine clearance 30-63 ml/min) and 7 patients with severe renal impairment had hypertension. The mean urinary recove...

journal_title：European journal of clinical pharmacology

authors： Larsson R,Liedholm H,Andersson KE,Keane MA,Henry G

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:The primary objective was to evaluate the effect of 7 days treatment with nimesulide on bleeding time. Blood coagulation, von Willebrand factor and platelet aggregation ex vivo were investigated as a secondary objective. METHOD:A randomised, double-blind, placebo-controlled, parallel group, single centre stu...

journal_title：European journal of clinical pharmacology

authors： Marbet GA,Yasikoff Strub ML,Macciocchi A,Tsakiris DA

更新日期：1998-07-01 00:00:00

abstract：:The influence of time of drug administration on pharmacokinetics of theophylline was studied both after ingestion of a sustained-release tablet, containing choline theophyllinate ( Zy 15061-S. R.; Teovent ; Sabidal ; ZYMA S.A.) and after intravenous infusion of aminophylline to eight healthy volunteers. Both drugs wer...

journal_title：European journal of clinical pharmacology

authors： Jonkman JH,van der Boon WJ,Balant LP,Schoenmaker R,Holtkamp A

更新日期：1984-01-01 00:00:00

abstract：:We gave 24 healthy elderly volunteers with a perceived sleep onset of at least 30 minutes zolpidem 5 mg, zolpidem 10 mg, or placebo for 7 days in a double-blind, three-way, crossover study. The morning after nocturnal dosing, psychomotor performance and cognitive ability were measured using tests which are sensitive t...

journal_title：European journal of clinical pharmacology

authors： Fairweather DB,Kerr JS,Hindmarch I

更新日期：1992-01-01 00:00:00

abstract：:The effect of spironolactone on cardiac contractility indices was studied by externally recording systolic time intervals in four digitalized and four non-digitalized patients with ischaemic heart disease. A negative inotropic effect was found after spironolactone 100mg b.i.d. in all eight patients, as measured by an ...

journal_title：European journal of clinical pharmacology

authors： Waldorff S,Berning J,Buch J,Steiness E

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Until recently, ondansetron was approved for the prevention of nausea and vomiting only in patients older than 2 years. However, as the use of ondansetron in patients younger than 2 years had been documented, characterization of ondansetron pharmacokinetics in this younger pediatric age group was warranted. ME...

journal_title：European journal of clinical pharmacology

authors： Mondick JT,Johnson BM,Haberer LJ,Sale ME,Adamson PC,Coté CJ,Croop JM,Russo MW,Barrett JS,Hoke JF

更新日期：2010-01-01 00:00:00

abstract：:Differences in the plasma concentrations of drugs after oral administration are caused by two main factors: variation in absorption ratios and in the distribution processes in the body. A new method for the dissection of both types of factors is discussed. The method uses a reference regression of the AUC-values to th...

journal_title：European journal of clinical pharmacology

authors： Betzien G,Kaufmann B,Schneider B

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To study the distribution of the thiopurine methyltransferase (TPMT) genotype among azathioprine (Aza)-tolerant and -intolerant patients with various disorders, and to investigate a possible relationship with the Aza metabolite levels. METHODS:Forty-six Aza-tolerant and six Aza-intolerant patients had the TP...

journal_title：European journal of clinical pharmacology

authors： Reuther LO,Vainer B,Sonne J,Larsen NE

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:This study investigated the effects of clotrimazole troche on the risk of transplant rejection and the pharmacokinetics of tacrolimus. METHODS:The data mining approach was used to investigate whether the use of clotrimazole increased the risk of transplant rejection in patients receiving tacrolimus therapy. Pa...

journal_title：European journal of clinical pharmacology

authors： Uno T,Wada K,Hosomi K,Matsuda S,Ikura MM,Takenaka H,Terakawa N,Oita A,Yokoyama S,Kawase A,Takada M

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Pharmacology and pharmacotherapy education is being increasingly integrated in medical curricula, which might lead to a specific loss of knowledge in these subjects. This, in turn, could lead to harmful prescribing errors, especially in vulnerable older patients. METHODS:Teachers who coordinated education in D...

journal_title：European journal of clinical pharmacology

authors： Keijsers CJ,de Wit JE,Tichelaar J,Brouwers JR,de Wildt DJ,de Vries PG,Jansen PA

更新日期：2015-05-01 00:00:00

abstract：:The kinetics of 14C-metformin have been studied in five healthy subjects after oral and intravenous administration. The intravenous dose was distributed to a small central compartment of 9.9 +/- 1.61 (X +/- SE), from which its elimination could be described using three-compartment open model. The elimination half-life...

journal_title：European journal of clinical pharmacology

authors： Pentikäinen PJ,Neuvonen PJ,Penttilä A

更新日期：1979-09-01 00:00:00

abstract：:The disposition of paracetamol following an oral dose of 1.0 g was compared in 10 healthy volunteers, 7 patients with moderate chronic renal failure and 6 patients with end stage renal failure on maintenance haemodialysis. Paracetamol absorption was normal in the patients with renal failure. The mean plasma half-life ...

journal_title：European journal of clinical pharmacology

authors： Prescott LF,Speirs GC,Critchley JA,Temple RM,Winney RJ

更新日期：1989-01-01 00:00:00

abstract：:Piretanide 60 mg was administered intravenously over 30 min to 15 men with different degrees of renal failure. The mean piretanide serum concentration at the end of the infusion period was 5.72 +/- 1.51 micrograms/ml. Serum piretanide concentration-time curves declined biexponentially and 24 hours after medication the...

journal_title：European journal of clinical pharmacology

authors： Walter U,Röckel A,Lahn W,Heidland A,Heptner W

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:This study evaluated the benefits of and possible contraindications to warfarin treatment in patients with atrial fibrillation (AF) prior to the introduction of new oral anticoagulants using health registry data from inpatient care, specialist ambulatory care, and primary care. METHODS:This is a cohort study i...

journal_title：European journal of clinical pharmacology

authors： Forslund T,Wettermark B,Wändell P,von Euler M,Hasselström J,Hjemdahl P

更新日期：2014-12-01 00:00:00

abstract：:The pharmacokinetics of theophylline was investigated in five hyperthyroid, five hypothyroid, and five euthyroid patients, all with chronic obstructive pulmonary disease. Wide individual variability was found in theophylline kinetics, but the rate of elimination of theophylline was significantly higher in hyperthyroid...

journal_title：European journal of clinical pharmacology

authors： Pokrajac M,Simić D,Varagić VM

更新日期：1987-01-01 00:00:00

abstract：:Seven patients with acutely elevated diastolic blood pressure (DBP greater than or equal to 135 mmHg) were treated with repeated injections of diazoxide 1 mg/kg body weight i.v. at 10-min intervals. If the DBP was not reduced to 110 mmHg or less after 5 injections, a dose of 5 mg/kg was given. Serum diazoxide (total a...

journal_title：European journal of clinical pharmacology

authors： McNair A,Andreasen F,Nielsen PE

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Opicapone is a novel third generation catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa pharmacokinetic profile throughout a day driven by the COMT inhibition either following repeated doses of opicapone or concomitant administration with enta...

journal_title：European journal of clinical pharmacology

authors： Rocha JF,Falcão A,Santos A,Pinto R,Lopes N,Nunes T,Wright LC,Vaz-da-Silva M,Soares-da-Silva P

更新日期：2014-09-01 00:00:00

abstract：:The pharmacokinetics of ceftazidime have been investigated after single and multiple i.v. doses in 9 young healthy male volunteers and 15 elderly male patients with acute bacterial infections. All subjects had normal, age-correlated glomerular function. Distribution and elimination in young volunteers were unaffected ...

journal_title：European journal of clinical pharmacology

authors： Ljungberg B,Nilsson-Ehle I

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of the two most common CYP2C9 variant alleles (*2 and *3) on the maintenance dose of warfarin and on the quality of anticoagulation control in Brazilians. METHODS:Patients (n = 103) initiated warfarin therapy with 5 mg/day (or 2.5 mg/day when over 80 years old). The international norma...

journal_title：European journal of clinical pharmacology

authors： Lima MV,Ribeiro GS,Mesquita ET,Victer PR,Vianna-Jorge R

更新日期：2008-01-01 00:00:00

abstract：:The study was done in healthy volunteers to investigate the vasoconstrictor activity of three commercially available formulations of fluocinolone acetonide (Synalar gel, cream and ointment) and to determine whether they were bioequivalent. The influence of dilution of the cream formulation on activity was also examine...

journal_title：European journal of clinical pharmacology

authors： Gao HY,Li Wan Po A

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Ultraviolet radiation exposure is the most important exogenous risk factor for cutaneous malignancies. It is possible that phototoxic drugs promote the development of cutaneous melanoma (CM) by intensifying the effect of ultraviolet light on the skin. We investigated the association between the use of common sy...

journal_title：European journal of clinical pharmacology

authors： Siiskonen SJ,Koomen ER,Visser LE,Herings RM,Guchelaar HJ,Stricker BH,Nijsten TE

更新日期：2013-07-01 00:00:00

abstract：:The purpose of this study was to examine the influence of cigarette smoking and gender on the pharmacokinetics of metoprolol. Eighteen volunteers with no evidence of clinical disease each randomly received the following doses of metoprolol tartrate: 100 mg orally, 200 mg orally and 20 mg as a constant-rate intravenous...

journal_title：European journal of clinical pharmacology

authors： Schaaf LJ,Campbell SC,Mayersohn MB,Vagedes T,Perrier DG

更新日期：1987-01-01 00:00:00

abstract：:The effects in vitro and in vivo of triiodothyronine on certain functions of human lymphocytes and polymorphonuclear granulocytes have been investigated. Triiodothyronine was able to enhance the phagocytic capacity and chemiluminescent activity of polymorphonuclear granulocytes. PHA-P-induced 3H-thymidine incorporatio...

journal_title：European journal of clinical pharmacology

authors： Balázs C,Leövey A,Szabó M,Bakó G

更新日期：1980-01-01 00:00:00

abstract：:To study the effects of enzyme induction on its pharmacokinetics, a single oral dose of the new antiarrhythmic agent mexiletine hydrochloride 400 mg was administered to 8 healthy volunteers before and after treatment with rifampicin 300 mg b.i.d. for ten days. The absorption and distribution of mexiletine were not cha...

journal_title：European journal of clinical pharmacology

authors： Pentikäinen PJ,Koivula IH,Hiltunen HA

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:Because of the risk of haemorrhagic disease of the newborn as a result of a deficit in vitamin K, it is generally agreed that newborns should receive vitamin K. However, there is no consensus concerning the route of administration, dose, number of doses, or dose frequency. METHODS:We studied patterns of vita...

journal_title：European journal of clinical pharmacology

authors： Jonville-Bera AP,Autret E

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:In Norway, very little data are available on the relation between the total number of research projects on the clinical development of drugs that have been started, the number of these projects in which the research phase has been completed and the number of projects for which results have been published. The...

journal_title：European journal of clinical pharmacology

authors： Hole OP,Nitter-Hauge S,Cederkvist HR,Winther FO

更新日期：2009-03-01 00:00:00

abstract：:There are many questions concerned with therapy and its application. Depending on the perspective of the study there can be several "populations" which, when considered individually, may give different, or even inconsistent conclusions. These populations are: the sick population, the therapist's target population, the...

journal_title：European journal of clinical pharmacology

authors： Collet JP,Boissel JP

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVES:To investigate the risk factors for noncompliance in elderly home-care recipients; and to evaluate to what extent regular home visits and drug counseling by a pharmacist contribute to compliance. SUBJECTS:One hundred and sixty-three elderly home-care recipients aged 62 years and over took part in this study...

journal_title：European journal of clinical pharmacology

authors： Okuno J,Yanagi H,Tomura S,Oka M,Hara S,Hirano C,Tsuchiya S

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:To explore the views and perspectives of children on the unlicensed/off-label use of medicines in children and on the participation of children in clinical trials. METHODS:Focus-group discussions, involving school children, were carried out in a range of primary and secondary schools in Northern Ireland. A ...

journal_title：European journal of clinical pharmacology

authors： Mukattash T,Trew K,Hawwa AF,McElnay JC

更新日期：2012-02-01 00:00:00