Use of I-131 labeled, murine Fab against a high molecular weight antigen of human melanoma: preliminary experience.

Abstract:

:High molecular weight antigen (HMWA) is a tumor-associated proteoglycan of human malignant melanoma. I-131 labeled Fab fragments of these specific antibodies were used for preliminary feasibility studies for radioimmunodetection and therapy of human subjects who had inoperable metastatic melanoma. Ten patients received tracer doses of 5-13 mCi (185-481 MBq) of I-131 (anti-HMWA) Fab. All patients (8/8) who had melanoma lesions greater than 1 cm by correlative diagnostic methods had one or more lesions that had localization to tumor of the radiolabeled Fab. In all, 17 of 23 (74%) documented metastases were seen. There were no false positives in this series. Two patients who had avid uptake received potentially radiotherapeutic doses of 142 mCi (5,254 MBq) (one patient) and 181 mCi (6,697 MBq) and 193 (7,141 MBq) (total: 374 mCi or 13,838 MBq) (one patient). For both of these patients, whole body imaging studies showed that the localization of the high dose I-131 Fab was predominantly in tumor. The patient who received the larger dose showed a greater than 50% reduction in the size of pelvic and pericaval nodes, with stabilization of disease at the smaller nodal size for a period of three months. On whole body images, the anti-Fab HMWA appears to be more tumor selective than Fab preparations that target the p97 antigen for melanoma, and there is less uptake in liver.

journal_name

Radiology

journal_title

Radiology

authors

Larson SM,Carrasquillo JA,McGuffin RW,Krohn KA,Ferens JM,Hill LD,Beaumier PL,Reynolds JC,Hellström KE,Hellström I

doi

10.1148/radiology.155.2.3983400

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

487-92

issue

2

eissn

0033-8419

issn

1527-1315

journal_volume

155

pub_type

杂志文章
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