当前位置： SCI文献检索 > ARCHIVES OF ORAL BIOLOGY期刊下所有文献 > Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease.

Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease.

Abstract：

BACKGROUND:Periodontal inflammation is driven by the coordinated action of a number of factors, including the IL-1 family. Our study aimed to examine the levels of interleukin (IL)-36β, IL-36γ and IL-33 levels in gingival crevicular fluid (GCF) from patients with different periodontal diseases. MATERIALS AND METHODS:A total of 80 subjects, 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with chronic periodontitis (CP), 20 with gingivitis and 20 periodontally healthy subjects were included. Periodontal status was evaluated by measuring probing depth, clinical attachment loss, papillary bleeding index and plaque index. GCF cytokine levels were analysed by ELISA. RESULTS:CP, gingivitis and healthy groups had similar GCF IL-36β total amount (p>0.008). G-AgP group had elevated IL-36β total amount compared to CP group (p<0.008). G-AgP group had similar GCF IL-36β total amount to gingivitis and healthy groups (p>0.008). GCF IL-36γ and IL-33 total amounts of the study groups were similar (p>0.05). CONCLUSIONS:The present study demonstrated for the first time the presence of IL-36β, IL-36γ and IL-33 GCF levels with different periodontal diseases. High levels of IL-36-β in the AgP group in comparison to CP group might suggest that periodontitis in the aggressive form could be related to the increase in GCF IL-36β.

journal_name

Arch Oral Biol

journal_title

Archives of oral biology

authors

Kurşunlu SF,Oztürk VÖ,Han B,Atmaca H,Emingil G

doi

10.1016/j.archoralbio.2014.08.021

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

77-83

issue

1

eissn

0003-9969

issn

1879-1506

pii

S0003-9969(14)00240-4

journal_volume

60

pub_type

杂志文章

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