Effect of cow's milk on the gastrointestinal tract: a persistent dilemma for the pediatrician.

Abstract:

:The confusing area of cow's milk intolerance is explored in an attempt to define the various mechanisms whereby milk affects gastrointestinal function, resulting in clinical symptoms (diarrhea, vomiting, gastrointestinal bleeding, etc.). The adverse reaction of infants to cow's milk ingestion may relate to lactose intolerance (enzymatic), a direct toxic reaction to the mucosal surface resulting in epithelial damage, or it may be immunologically mediated. Factors such as increased intestinal permeability to milk proteins during the newborn period may also contribute to susceptibility of young infants to milk sensitivity. The relative roles of systemic (milk agglutinins) and local immunity (SIgA antibodies) in milk intolerance are discussed and differential immunologic responses (IgE versus IgA/IgM) considered in the pathogenesis. It was concluded that new techniques such as organ culture of intestinal biopsy specimens are needed to establish the diagnosis of hypersensitivity and to begin to provide ways of adequately treating the condition.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Eastham EJ,Walker WA

subject

Has Abstract

pub_date

1977-10-01 00:00:00

pages

477-81

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

60

pub_type

杂志文章
  • Reforming Medicaid for medically complex children.

    abstract::Children's hospitals play a central role in our child health care system. These hospitals face unique challenges under health care reform. They care for children with the most complex medical problems but often are not reimbursed for good preventive care, care coordination, or quality. We discuss a proposal by childre...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0252g

    authors: O'Donnell R

    更新日期:2013-04-01 00:00:00

  • Autistic and dysphasic children. II: Epilepsy.

    abstract::In a previously described population of 314 autistic and 237 dysphasic nonautistic children, after exclusion of 12 autistic girls with Rett syndrome, 14% (42 of 302) of autistic children and 8% (19 of 237) of dysphasic children had epilepsy (P = .03). The major risk factors for epilepsy were severe mental deficiency a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Tuchman RF,Rapin I,Shinnar S

    更新日期:1991-12-01 00:00:00

  • Reversible left recurrent laryngeal nerve palsy in pediatric Graves' disease.

    abstract::Vocal cord paralysis associated with goiter usually indicates the presence of a malignancy. Pediatric patients retain significant thymic tissue that regresses only later in life. This thymic tissue can develop significant hyperplasia during an acute autoimmune process. We describe a case of a 17-year-old girl who pres...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0437

    authors: Chiu HK,Ledbetter D,Richter MW,Iyer RS,Merati AL

    更新日期:2013-12-01 00:00:00

  • Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants.

    abstract:BACKGROUND:Although caffeine use for apnea of prematurity is well studied, the long-term safety and benefit of routine early caffeine administration has not been explored. Our objective was to determine the association between early (within 2 days of birth) versus late caffeine exposure and neurodevelopmental outcomes ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-1348

    authors: Lodha A,Entz R,Synnes A,Creighton D,Yusuf K,Lapointe A,Yang J,Shah PS,investigators of the Canadian Neonatal Network (CNN) and the Canadian Neonatal Follow-up Network (CNFUN).

    更新日期:2019-01-01 00:00:00

  • Disparities in Service Use Among Children With Autism: A Systematic Review.

    abstract:CONTEXT:Research reveals racial, ethnic, and socioeconomic disparities in autism diagnosis; there is limited information on potential disparities related to other dimensions of services. OBJECTIVE:We reviewed evidence related to disparities in service use, intervention effectiveness, and quality of care provided to ch...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-1895G

    authors: Smith KA,Gehricke JG,Iadarola S,Wolfe A,Kuhlthau KA

    更新日期:2020-04-01 00:00:00

  • Racial and ethnic disparities in medical and dental health, access to care, and use of services in US children.

    abstract:BACKGROUND:Not enough is known about the national prevalence of racial/ethnic disparities in children's medical and dental care. OBJECTIVE:The purpose of this work was to examine racial/ethnic disparities in medical and oral health, access to care, and use of services in a national sample. METHODS:The National Survey...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1243

    authors: Flores G,Tomany-Korman SC

    更新日期:2008-02-01 00:00:00

  • Fruit juice intake predicts increased adiposity gain in children from low-income families: weight status-by-environment interaction.

    abstract:OBJECTIVE:Our goal was to test the hypothesis that increased fruit juice intake and parental restriction of children's eating are associated with increased adiposity gain and whether exposure to nutritional counseling predicted reduced adiposity gain among children. PATIENTS AND METHODS:A sample of parents or guardian...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1117

    authors: Faith MS,Dennison BA,Edmunds LS,Stratton HH

    更新日期:2006-11-01 00:00:00

  • Variability in head circumference growth rate during the first 2 years of life.

    abstract::The head circumference (HC) curves were plotted for a group of 415 healthy full-term babies over the first 2 years of life. Two hundred ten (51%) of the cohort demonstrated HC variability, defined as an HC acceleration or deceleration of at least 1 centile curve for at least 2 months. Of these, the deceleration patter...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jaffe M,Tal Y,Hadad B,Tirosh E,Tamir A

    更新日期:1992-08-01 00:00:00

  • Parental separation and pediatric cancer: a Danish cohort study.

    abstract:OBJECTIVE:The purpose of this study was to determine the risk for separation (ending cohabitation) of the parents of a child with a diagnosis of cancer. METHODS:In a nationwide cohort, we compared the risk for ending cohabitation of the parents of 2450 children (aged 0-20 years) given a diagnosis of cancer with the ri...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-2657

    authors: Grant S,Carlsen K,Bidstrup PE,Bastian GS,Lund LW,Dalton SO,Johansen C

    更新日期:2012-05-01 00:00:00

  • Unilateral hearing loss is associated with worse speech-language scores in children.

    abstract:OBJECTIVE:To determine whether children with unilateral hearing loss (UHL) demonstrate worse language skills than their siblings with normal hearing, and whether children with UHL are more likely to receive extra assistance at school. PATIENTS AND METHODS:We conducted a case-control study of 6- to 12-year-old children...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2448

    authors: Lieu JE,Tye-Murray N,Karzon RK,Piccirillo JF

    更新日期:2010-06-01 00:00:00

  • Subscapular abscess due to Haemophilus influenzae type B.

    abstract::Localized abscess formation is a rare but previously described manifestation of Haemophilus influenzae infection. A majority of the reported cases were caused by nontypeable strains of H influenzae. We report a case of an extensive subscapular abscess due to beta-lactamase-negative H influenzae type B. This, to our kn...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: San Joaquin VH,Kimball JB

    更新日期:1980-02-01 00:00:00

  • Early dexamethasone therapy in preterm infants: a follow-up study.

    abstract:OBJECTIVES:To study the outcome at 2-year corrected age of infants who participated in a double-blind controlled trial of early (<12 hours) dexamethasone therapy for the prevention of chronic lung disease (CLD). METHODS AND MATERIALS:A total of 133 children (70 in the control group, 63 in the dexamethasone-treated gro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.5.e7

    authors: Yeh TF,Lin YJ,Huang CC,Chen YJ,Lin CH,Lin HC,Hsieh WS,Lien YJ

    更新日期:1998-05-01 00:00:00

  • Booster seat laws and fatalities in children 4 to 7 years of age.

    abstract:OBJECTIVE:To determine whether state booster seat laws were associated with decreased fatality rates in children 4 to 7 years of age in the United States. METHODS:Retrospective, longitudinal analysis of all motor vehicle occupant crashes involving children 4 to 7 years of age identified in the Fatality Analysis Report...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1058

    authors: Mannix R,Fleegler E,Meehan WP 3rd,Schutzman SA,Hennelly K,Nigrovic L,Lee LK

    更新日期:2012-12-01 00:00:00

  • The Use of Pyridostigmine in a Child With Chronic Intestinal Pseudo-Obstruction.

    abstract::Chronic intestinal pseudo-obstruction is a rare disorder that affects the motility of the gastrointestinal tract. It results in acute or subacute intestinal obstruction symptoms in the absence of mechanical lesion. It can lead to intestinal failure in children with significant strain on nutrition, growth, and developm...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0007

    authors: Choudhury A,Rahyead A,Kammermeier J,Mutalib M

    更新日期:2018-04-01 00:00:00

  • Rumination--a new complication of neonatal intensive care.

    abstract::The infant rumination syndrome has not been previously reported in a neonatal intensive care setting. We recently managed three infants in our newborn intensive care unit who developed rumination following chronic courses in the unit. The events leading to this condition in each infant are described, as well as the su...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sheagren TG,Mangurten HH,Brea F,Lutostanski S

    更新日期:1980-10-01 00:00:00

  • Trends in Access to Health Care Services for US Children: 2000-2014.

    abstract:BACKGROUND AND OBJECTIVE:Recent years have witnessed substantial gains in health insurance coverage for children, but few studies have examined trends across a diverse set of access indicators. We examine US children's access to health services and whether trends vary by race/ethnicity and income. METHODS:Analysis of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-2176

    authors: Larson K,Cull WL,Racine AD,Olson LM

    更新日期:2016-12-01 00:00:00

  • Recommendations for Prevention and Control of Influenza in Children, 2016-2017.

    abstract::The purpose of this statement is to update recommendations for the routine use of seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. The AAP recommends annual seasonal influenza immunization for everyone 6 months and older, including children and adolescents...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2016-2527

    authors: COMMITTEE ON INFECTIOUS DISEASES.

    更新日期:2016-10-01 00:00:00

  • Cigarette Tax Increase and Infant Mortality.

    abstract:BACKGROUND AND OBJECTIVE:Maternal smoking increases the risk for preterm birth, low birth weight, and sudden infant death syndrome, which are all causes of infant mortality. Our objective was to evaluate if changes in cigarette taxes and prices over time in the United States were associated with a decrease in infant mo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2901

    authors: Patrick SW,Warner KE,Pordes E,Davis MM

    更新日期:2016-01-01 00:00:00

  • The emergency physician and the office-based pediatrician: an EMSC team. American Academy of Pediatrics. Committee on Pediatric Emergency Medicine.

    abstract::In a quality and cost-conscious health care environment, the pediatrician and emergency physician must work as a team. This statement clarifies important issues of this relationship, including coordination of patient care, communication between clinicians, provision of continuity care, and responsibility for quality e...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.5.936

    authors:

    更新日期:1998-05-01 00:00:00

  • Ostensible versus actual reasons for seeking pediatric attention: another look at the parental ticket of admission.

    abstract::The presentation of parental anxiety that appears excessive in view of the nature of the child's "chief complaint" is a frequent occurrence in pediatric practice. This study reviews 370 sick-patient visits in one pediatric office during a three-month period. Additional questioning in the area of parental anxieties con...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bass LW,Cohen RL

    更新日期:1982-12-01 00:00:00

  • Pediatric Readiness in Emergency Medical Services Systems.

    abstract::This is a joint policy statement from the American Academy of Pediatrics, American College of Emergency Physicians, Emergency Nurses Association, National Association of Emergency Medical Services Physicians, and National Association of Emergency Medical Technicians on pediatric readiness in emergency medical services...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.2019-3307

    authors: Moore B,Shah MI,Owusu-Ansah S,Gross T,Brown K,Gausche-Hill M,Remick K,Adelgais K,Lyng J,Rappaport L,Snow S,Wright-Johnson C,Leonard JC,AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON PEDIATRIC EMERGENCY MEDICINE AND SECTION ON EMER

    更新日期:2020-01-01 00:00:00

  • Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study.

    abstract:OBJECTIVES:Antimicrobial treatment may disturb the colonization resistance of gastrointestinal microflora, which may induce clinical symptoms, most commonly diarrhea. The severity of antibiotic-associated diarrhea may range from a brief, self-limiting disease to devastating diarrhea with electrolyte disturbances, dehyd...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.104.5.e64

    authors: Arvola T,Laiho K,Torkkeli S,Mykkänen H,Salminen S,Maunula L,Isolauri E

    更新日期:1999-11-01 00:00:00

  • Successful treatment of bowenoid papulosis in a 9-year-old girl with vertically acquired human immunodeficiency virus.

    abstract::A 9-year-old black girl with vertically acquired human immunodeficiency virus (HIV) and no history of condyloma acuminata presented with a 4-year history of enlarging and spreading dark brown flat papules in the perineum. Some of the lesions were confluent and extended from the clitoris to the labia majora and posteri...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.112.1.e73

    authors: Godfrey JC,Vaughan MC,Williams JV

    更新日期:2003-07-01 00:00:00

  • Secondhand smoke exposure and neurobehavioral disorders among children in the United States.

    abstract:OBJECTIVES:The association between parent-reported postnatal secondhand tobacco smoke exposure in the home and neurobehavioral disorders (attention-deficit/hyperactivity disorder, learning disabilities, and conduct disorders) among children younger than 12 years in the United States was examined using the 2007 National...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0023

    authors: Kabir Z,Connolly GN,Alpert HR

    更新日期:2011-08-01 00:00:00

  • Family history predicts stress fracture in active female adolescents.

    abstract:OBJECTIVE:Increased physical activity and menstrual irregularity have been associated with increased risk for stress fracture among adult women active in athletics. The purposes of this study were to determine whether menstrual irregularity is also a risk factor for stress fracture in active female adolescents and to e...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-2145

    authors: Loud KJ,Micheli LJ,Bristol S,Austin SB,Gordon CM

    更新日期:2007-08-01 00:00:00

  • Self- and parent-rated executive functioning in young adults with very low birth weight.

    abstract:BACKGROUND AND OBJECTIVE:Adults born preterm score lower on performance-based tests of executive functioning (EF) than their term-born peers. These test scores do not necessarily translate to application of these skills in an everyday environment. The objective of the study was to test differences between very low birt...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0839

    authors: Heinonen K,Pesonen AK,Lahti J,Pyhälä R,Strang-Karlsson S,Hovi P,Järvenpää AL,Eriksson JG,Andersson S,Kajantie E,Raikkonen K

    更新日期:2013-01-01 00:00:00

  • Treatment of plastic bronchitis in a Fontan patient with tissue plasminogen activator: a case report and review of the literature.

    abstract::Plastic bronchitis is a condition in which large, bronchial casts with rubber-like consistency develop in the tracheobronchial tree and cause airway obstruction. We describe a 4-year-old girl who had Fontan physiology and who developed plastic bronchitis and report for the first time the use of aerosolized tissue plas...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.109.4.e67

    authors: Costello JM,Steinhorn D,McColley S,Gerber ME,Kumar SP

    更新日期:2002-04-01 00:00:00

  • Total population estimate of newborn special-care bed needs.

    abstract::In 1977, 7% of the 38,855 infants born in Utah were estimated to have required a total of 27,439 special-care hospital days. About half (53%) were mildly ill; their average length of stay was 4.6 days, or 24% of the total hospital-days. Another 20% of the infants had intermediate illness, with a 12-day average stay, o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jung AL,Streeter NS

    更新日期:1985-06-01 00:00:00

  • Four patterns of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn.

    abstract:OBJECTIVE:To determine the clinical role of inhaled nitric oxide (iNO) in the treatment of persistent pulmonary hypertension of the newborn (PPHN). STUDY DESIGN:Prospective open observational clinical study. SETTING:A regional cardiac and pediatric intensive care unit. METHODS:Twenty-five consecutive near-term neona...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Goldman AP,Tasker RC,Haworth SG,Sigston PE,Macrae DJ

    更新日期:1996-10-01 00:00:00

  • Incidence of respiratory distress syndrome following antenatal betamethasone: role of sex, type of delivery, and prolonged rupture of membranes.

    abstract::Premature male infants have a higher incidence of respiratory distress syndrome (RDS) than female infants (male/female = 1.7:1.) With the demonstration that antenatal use of betamethasone significantly reduces the incidence of RDS, a proportional reduction or possibly a complete elimination of the discrepancy between ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Papageorgiou AN,Colle E,Farri-Kostopoulos E,Gelfand MM

    更新日期:1981-05-01 00:00:00