Abstract:
BACKGROUND:Antimicrobial exposure remains an important risk factor for developing Clostridium difficile infection (CDI). Efficient method to identify antibiotics associated with CDI is important for formulating strategies to curtail their use. As a prelude to a more extensive Agency for Healthcare Research and Quality-funded project (Evaluation & Research on Antimicrobial Stewardship's Effect on Clostridium difficile), we undertook an exploratory evaluation to determine a resource-efficient method for identifying antibiotic targets for antimicrobial stewardship interventions. METHODS:The study compared a series of 6 focused case-control studies. Cases consisted of patients with laboratory-confirmed CDI admitted from July-October 2009. Controls were selected from patients without CDI hospitalized during the same period. Five groups of controls were matched to cases (2:1 ratio) using group-specific matching criteria, including admission date, age, type of admission, length of stay (LOS) to discharge, and/or LOS to CDI diagnosis. The final control group was selected from patients who received antibiotics during hospitalization. Data, including demographics and antibiotic usage, were compared between case and control groups. RESULTS:A total of 126 cases were matched to 6 groups of 252 controls. For control groups 1-5, the use of piperacillin and tazobactam, ceftriaxone or cefepime, ciprofloxacin or moxifloxacin, intravenous vancomycin, azithromycin, and antibiotics of last resort were significantly more frequent in case than control patients. For the final control group, the associations between ceftriaxone or cefepime, and ciprofloxacin or moxifloxacin use and CDI no longer persisted. This could in part be explained by differences in comorbidities between case and control patients even with stringent matching criteria. CONCLUSION:Use of a simple matching strategy to conduct case-control studies is an efficient and feasible compromise strategy, especially in resource-limited settings, to identify high-risk antibiotics associated with CDI.
journal_name
Am J Infect Controljournal_title
American journal of infection controlauthors
Chung P,Currie B,Guo Y,Talansky M,Brown S,Ostrowsky Bdoi
10.1016/j.ajic.2014.05.001subject
Has Abstractpub_date
2014-10-01 00:00:00pages
S264-8issue
10 Suppleissn
0196-6553issn
1527-3296pii
S0196-6553(14)00791-3journal_volume
42pub_type
杂志文章abstract::To assess the implementation of hepatitis B virus (HBV) vaccination programs for hospital workers, we mailed questionnaires to all 229 licensed Michigan hospitals. The response rate was 96% (221/229); of these, 68% (150/221) had vaccination programs. Although multiple hospital characteristics were associated with the ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(88)90059-4
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND:The incidence of postoperative surgical site infections (SSIs) is difficult to estimate because of the current trend of early discharge after surgery. Both operation-related and host factors should be taken into consideration in the prevention of SSIs. We wanted to determine the actual incidence of SSIs and ...
journal_title:American journal of infection control
pub_type: 临床试验,杂志文章
doi:10.1016/s0196-6553(97)90082-1
更新日期:1997-10-01 00:00:00
abstract::Between Jan. 11 and March 31, 1983, 60 pediatric patients were diagnosed with rotavirus gastroenteritis. Of these cases 24 were community acquired, 29 were nosocomial, and 7 were of undetermined origin. Despite intensive infection control efforts, nosocomial transmission continued as long as patients with community-ac...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(90)90207-9
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Antibiotic resistance is a threat to global health security. We assessed knowledge, attitudes, and practices in regard to antibiotic prescribing and resistance in Cambodian physicians from public hospitals. METHODS:A cross-sectional knowledge, attitudes, and practices survey was distributed to physicians fr...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.03.062
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Numerous strategies are available to prevent surgical site infections in hip arthroplasty, but there is no consensus on which might be the best. This study examined infection prevention strategies currently recommended for patients undergoing hip arthroplasty. METHODS:Four clinical guidelines on infection p...
journal_title:American journal of infection control
pub_type: 杂志文章,评审
doi:10.1016/j.ajic.2012.03.027
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Meningococcal disease remains a major concern in populations living under crowded conditions. Following the 1995 report of several cases of meningococcal disease in Israeli soldiers, the Department of Epidemiology of the Army Health Branch, Israel Defense Forces (IDF) adopted an immunization policy for all r...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2009.04.290
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Insufficient use of behavioral theory to understand health care workers' (HCWs) hand hygiene compliance may result in suboptimal design of hand hygiene interventions and limit effectiveness. Previous studies examined HCWs' intended, rather than directly observed, compliance and/or focused on just 1 behaviora...
journal_title:American journal of infection control
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ajic.2013.07.019
更新日期:2014-02-01 00:00:00
abstract::Oral care is an important component of the ventilator bundle; however, few studies have investigated the factors related to compliance with performing oral care among critical care nurses. In this observational study of 759 oral care opportunities performed by 133 critical care nurses, we found that the overall oral c...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2014.01.023
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:This study assessed reporting behavior and satisfaction with postexposure prophylaxis (PEP) systems among health care workers (HCWs) at risk for occupational bloodborne pathogen exposure (BPE) in 3 public hospitals in Botswana. METHODS:A cross-sectional survey among HCWs provided information on perceptions,...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.01.027
更新日期:2016-08-01 00:00:00
abstract::Respondents (N = 473) from a randomized stratified sample (N = 600) of U.S. hospital ICPs in a national survey sponsored by the Certification Board of Infection Control were asked to rate specific task, knowledge, and ability statements related to infection control for frequency and importance. The questions included ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(84)90096-8
更新日期:1984-06-01 00:00:00
abstract::Central line-associated bloodstream infection (CLABSI) event data reported to the National Healthcare Safety Network from 2014, the first year of required use of the mucosal barrier injury laboratory-confirmed bloodstream infection (MBI-LCBI) definition, were analyzed to assess the impact of removing MBI-LCBI events f...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2016.10.015
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:In the United States incidence of sepsis and pneumonia differ by race, but it is unclear whether this is due to intrinsic factors or health care factors. METHODS:We conducted a study of 52,006 patients hospitalized during 2006-2008 at a referral hospital in upper Manhattan. We examined how the prevalence of...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2014.08.019
更新日期:2014-12-01 00:00:00
abstract::The holistic principles of hygiene and public health have contributed substantially to an increase in life expectancy by more than 30 years and in life quality since the beginning of the 20th century. Frank, Pettenkofer, Nightingale, Pasteur, Lister, and Koch have been pioneering protagonists of the holistic approach ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1067/mic.2001.115680
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:With the increasing volume of same-day operations and shortened hospital stays, it becomes more likely that a significant percentage of surgical site infections will occur after these patients' discharges. METHODS:To document the true incidence of postdischarge surgical site infection, surveillance was unde...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/0196-6553(95)90004-7
更新日期:1995-02-01 00:00:00
abstract::Since first reported in Europe in the early 1980s, extended-spectrum beta-lactamases (ESBLs) have spread worldwide. When producing these broad-spectrum plasmid-encoded enzymes, organisms become highly effective at inactivating penicillins, most cephalosporins, and aztreonam. Mainly produced by Klebsiella spp, ESBLs ha...
journal_title:American journal of infection control
pub_type: 杂志文章,评审
doi:10.1016/j.ajic.2004.07.010
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Infection control partially depends on hygiene and communication skills. Unfortunately, motivation for continuous training is lower than desired. Many health care providers (HCPs) do not recognize the need for training but express this need for others. This is attributable to heuristic errors, such as the ov...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2018.10.022
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Little is known about the direct economic burden associated with health care-associated infection (HAI) in patients undergoing colorectal cancer surgery in China. This study aims to fill this knowledge gap. METHODS:This study was a prospective monitoring case-control study. The direct economic burden was pr...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2017.08.003
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Previous studies have drawn different conclusions about the impact of Candida airway colonization on clinical outcomes in patients with ventilator-associated pneumonia (VAP). METHODS:We searched PubMed, the Cochrane Library, Embase (via OVID), and Web of Science database. We included both retrospective and ...
journal_title:American journal of infection control
pub_type: 杂志文章,评审
doi:10.1016/j.ajic.2019.11.002
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Since the introduction in the 1970s of surgical hand scrub formulations that contain 4% chlorhexidine gluconate (CHG), new surgical scrub formulations that have improved efficacy, persistence, or significantly improved use characteristics have not been forthcoming. In addition, the manufacturer's labeling fo...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/s0196-6553(98)70024-0
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:Candidemia in children caused by non-albicans Candida (NAC) spp is increasing in prevalence, but the relevant information is limited. METHODS:All isolates of pediatric candidemia from a medical center in Taiwan between 2003 and 2015 were enrolled. The characteristics of patients with NAC and Candida albican...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2018.05.015
更新日期:2018-12-01 00:00:00
abstract::We report a comparative laboratory study between 2 peripheral intravenous catheters equipped with a passive fully automatic safety mechanism to assess generation of blood droplets during withdrawal. One presented no fluid droplets, whereas the other presented droplets in 48% and 60% for the best and worst case, with a...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2014.11.020
更新日期:2015-03-01 00:00:00
abstract::Surgical instrument trays are wrapped for sterilization, and these wraps are inspected by operating room personnel for defects before using the instruments. In this study, we intentionally damaged wraps, and these wraps were evaluated by operating room personnel. Examiners correctly identified a wrapper's sterile inte...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2017.11.031
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Thermally injured patients are at high risk for infections, including hospital acquired infections (HAIs). We modeled a twice-daily chlorhexidine gluconate (CHG) bath protocol aimed at decreasing HAIs. METHODS:Bathing with a 0.9% CHG solution in sterile water was provided twice daily as part of routine care...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2013.08.015
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Animal-assisted intervention (AAI) programs are increasing in popularity, but it is unknown to what extent therapy animal organizations that provide AAI and the hospitals and eldercare facilities they work with implement effective animal health and safety policies to ensure safety of both animals and humans....
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2017.04.287
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:This study was undertaken to determine the temporal relationship between implementation of different interventions in an intensive care unit (ICU) and control of endemic nosocomial acquisition of extended-spectrum β-lactamase Enterobacteriaceae (ESBLE). METHODS:This was a prospective observational study wit...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2015.07.026
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Healthcare workers perform hand hygiene much more frequently than workers in other fields. As a result, healthcare workers have a higher exposure to topical antiseptic products. METHODS:Five tertiary care facilities were equipped with an electronic hand hygiene compliance monitoring system. Alcohol-based ha...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2018.04.205
更新日期:2018-10-01 00:00:00
abstract::In this study examining public health workers' 2009 H1N1 and seasonal influenza vaccination uptake, a survey was conducted to assess flu vaccine acceptance, as well as behaviors and beliefs regarding acceptance, among public health workers in southeastern Tennessee. Factors found to be significantly associated with ac...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2011.05.010
更新日期:2012-04-01 00:00:00
abstract::Hand dermatitis as a result of frequent exposure to water and cleansing agents is a significant problem in the health care industry. In developing prevention efforts to address this problem, it is necessary to make appropriate recommendations for moisturizers that are compatible with latex gloves and/or handwashing ag...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1067/mic.2001.117298
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Health care-associated opportunistic pathogens Staphylococcus aureus and Enterococcus faecium persist on dry environments and can contribute to organism transmission through contact. These organisms can be monitored on surfaces by culture, molecular methods, or metabolic assays. This study was designed to de...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2017.07.027
更新日期:2018-01-01 00:00:00
abstract::There are no standard guidelines for infection prevention and control practices among solid organ transplantation centers. To characterize the differences in infection prevention and control strategies, an electronic survey was performed in 2015 among members of American Society of Transplantation Infectious Diseases ...
journal_title:American journal of infection control
pub_type: 杂志文章
doi:10.1016/j.ajic.2018.06.020
更新日期:2019-01-01 00:00:00