Abstract：
OBJECTIVES:Our aims were to assess the progression rate of normotension and prehypertension to hypertension in Japan, and the effect of the new-onset hypertension on chronic kidney disease (CKD). METHODS:This was a nationwide study of 45 378 Japanese aged 40-74 years (mean age 60 years, 37% men) without hypertension or cardiovascular disease at baseline. At baseline and 3-year follow-up, blood pressure (BP) and kidney function were assessed. CKD was defined as an estimated glomerular filtration rate (eGFR) below 60 ml/min per 1.73 m² or the presence of proteinuria (≥1+ by a dipstick). RESULTS:At 3-year follow-up, the incidence rates of hypertension among participants with optimal BP (<120/80 mmHg, n = 18,724), normal BP (120-129/80-84 mmHg, n = 15,017) and high-normal BP (130-139/85-89 mmHg, n = 11,637) were 8, 23, and 39% in men, and 6, 20, and 37% in women, respectively. Among those without CKD at baseline (n = 42,625), 2142 participants (5%) had developed CKD during follow-up. Irrespective of the baseline BP classifications, participants with new-onset hypertension had a higher risk for proteinuria [odds ratio (95% confidence interval) 1.7 (1.3-2.3) in men and 1.6 (1.2-2.2) in women], but not for eGFR below 60 ml/min per 1.73 m², compared with those who maintained optimal BP during follow-up. Men who remained in the high-normal BP range during follow-up showed higher risk for proteinuria [odds ratio (95% confidence interval) 1.6 (1.1-2.3)], but not for eGFR below 60 ml/min per 1.73 m². CONCLUSIONS:This nationwide longitudinal study suggests that, over 3 years of follow-up, women and men with new-onset hypertension and men with high-normal BP were at higher risk of newly developing proteinuria.
journal_name
J Hypertensjournal_title
Journal of hypertensionauthors
Yano Y,Fujimoto S,Sato Y,Konta T,Iseki K,Iseki C,Moriyama T,Yamagata K,Tsuruya K,Narita I,Kondo M,Kimura K,Asahi K,Kurahashi I,Ohashi Y,Watanabe Tdoi
10.1097/HJH.0000000000000344subject
Has Abstractpub_date
2014-12-01 00:00:00pages
2371-7; discussion 2377issue
12eissn
0263-6352issn
1473-5598journal_volume
32pub_type
杂志文章abstract：OBJECTIVES:Several studies have shown lower carotid-femoral pulse wave velocity (cfPWV) levels in women compared to men, a difference that could partially explain the increased longevity in women. However, these studies have been performed in industrial countries while few data are available in emerging populations. We...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e3283639460
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVES:We aimed to determine the association of nonalcoholic fatty liver disease (NAFLD) with central and peripheral blood pressure (BP), in a general adolescent population and to examine whether associations are independent of adiposity. METHODS:Using cross-sectional data from a subsample (N = 1904) of a UK birth...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000445
更新日期：2015-03-01 00:00:00
abstract：OBJECTIVES:Aortic (central) blood pressure (BP) differs from brachial BP and may be a superior predictor of cardiovascular events. However, its measurement is currently restricted to research settings, owing to a moderate level of operator dependency. We tested a new noninvasive device in a large UK cohort. The device ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000082
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Haemostatic factors may play a part in the development of acute coronary heart disease. OBJECTIVE:To evaluate as predictors of major coronary events (fatal and non-fatal myocardial infarctions and sudden death) levels of fibrinogen, von Willebrand factor, prothrombin fragment 1+2, thrombin-antithrombin comp...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199816040-00016
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Aldosterone has essential roles in regulating intravascular volume and blood pressure, and is suggested to influence cardiac structure. However, the association of polymorphisms in the aldosterone synthase gene (CYP11B2) with hypertension or cardiac hypertrophy remains controversial. OBJECTIVE:To evaluate t...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/01.hjh.0000170377.00591.7e
更新日期：2005-06-01 00:00:00
abstract：OBJECTIVE:To study blood pressure and antihypertensive drug treatment in subjects with contrasting family histories of hypertension. SUBJECTS AND METHODS:We grouped 520 offspring examined in 1990 (mean +/- SD age 36 +/- 7 years) according to their parents' blood pressure screened in 1963-1964 as offspring of two normo...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:High sodium intake is associated with increased risk of end-organ damage, independent of blood pressure (BP) levels. The protective peptide adiponectin may play a role in the pathogenesis of hypertension and particularly in salt-loaded conditions. Furthermore, increased adiponectin levels were observed in sa...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e3283325eee
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:We examined the effects of a calcium antagonist and an angiotensin converting enzyme (ACE) inhibitor on contractile and non-contractile protein metabolism and cardiac function in a monocrotaline-induced right ventricular hypertrophy model, in order to define the effects of these drugs on cardiac hypertrophy. ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension. Me...
journal_title：Journal of hypertension
pub_type： 杂志文章,评审
doi：10.1097/HJH.0000000000000168
更新日期：2014-06-01 00:00:00
abstract：:Twenty-four adolescent boys with a positive and 40 boys with a negative parental history of hypertension (PH+ and PH-, respectively) were studied at rest and during exercise on a bicycle ergometer at work loads ranging from 25 to 150 W. Each group was divided into fit and unfit categories on the basis of oxygen consum...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND AND METHOD:This study evaluated the effects of a linear block strength training programme on the parameters of cardiac remodelling in spontaneously hypertensive rats. Thirty-nine rats were equally distributed in four groups: normotensive sedentary, normotensive trained, hypertensive sedentary and hypertensiv...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000002188
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:To examine the changes in plasma brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and blood pressure in patients with essential hypertension on a low, normal and high sodium intake. DESIGN AND METHODS:Twelve patients with mild-to-moderate essential hypertension were studied. Plasma, urinary ...
journal_title：Journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-07-01 00:00:00
abstract：:Several myosin isoforms are expressed in smooth muscle, based upon both heavy and light chain polymorphisms. These myosin isoenzymes reveal distinct detachment rate constants, thus regulating the responsiveness of the VSMC contractile apparatus to Ca2+, as well as its energetical and mechanical behavior. ...
journal_title：Journal of hypertension
pub_type： 杂志文章,评审
doi：10.1097/00004872-199205000-00002
更新日期：1992-05-01 00:00:00
abstract：OBJECTIVE:To determine the relationship between arterial function (stiffness and wave reflection) and glomerular hemodynamics. METHODS:In 49 healthy normotensive individuals, glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were measured by urinary clearances of 99mTC-DTPA and 131I-hippuran, res...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32833e2a21
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVE:Nailfold capillary density was measured at rest and after 4 min circulatory arrest in order to investigate the relationship between sodium-sensitive hypertension and microvessel density. DESIGN:Seventeen sodium-sensitive and 28 sodium-resistant young borderline hypertensive males and 10 normotensive controls...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:We examined the relation between cardiovascular reactivity (the response of the cardiovascular system to psychological stress) and the severity and progression of carotid atherosclerosis. METHODS:Using duplex ultrasonography, we measured the change in the area of all detectable plaques in the extracranial c...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199715010-00004
更新日期：1997-01-01 00:00:00
abstract：INTRODUCTION:Abnormalities of calcium metabolism independent of changes in intracellular calcium have been described in patients with essential hypertension. These include increased urinary calcium excretion for a given salt intake, a raised parathyroid hormone level, an increase in urinary cyclic AMP, a tendency for a...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199308000-00003
更新日期：1993-08-01 00:00:00
abstract：BACKGROUND:Epidemiological investigations have demonstrated a close association between heavy alcohol consumption and hypertension. The mechanisms of this association, however, remain elusive. We studied the effects of alcohol withdrawal on blood pressure, hormonal parameters, and circulating markers of endothelial act...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/01.hjh.0000239283.35562.15
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVES:Renal denervation (RDN) can reduce sympathetic activity and blood pressure (BP) in patients with hypertension. The effects on resting and ambulatory heart rate (HR), also regulated by the sympathetic nervous system, are not established. METHODS:Herein, we report 12-month outcomes from the Global SYMPLICITY ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001085
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Dipeptidyl peptidase-4 (DPP4) is a key protein in glucose homeostasis and a pharmacological target in type 2 diabetes mellitus. This study explored whether the novel adipokine soluble DPP4 (sDPP4) can cause endothelial dysfunction, an early marker of impaired vascular reactivity. METHOD:Reactivity was studi...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000000886
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:To investigate the association between hypertension and musculoskeletal complaints among men and women selected by a population-based sample. METHODS:A cross-sectional study, with participants selected using a multistage sampling procedure and interviewed at home, was conducted to investigate the association...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e3283588268
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:In patients with type 2 diabetes mellitus (T2DM), blocking of the renin-angiotensin-aldosterone system (RAAS) has demonstrated efficacy in lowering blood pressure (BP) and urinary albumin excretion rate (UAER). Nonetheless, not all patients successfully respond to RAAS blockade with a reduction in BP and UAER...
journal_title：Journal of hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1097/HJH.0b013e32834a8a25
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to assess the role of transforming growth factor (TGF)-beta1 in the development of diabetes-associated mesenteric vascular hypertrophy and in the antitrophic effect of angiotensin converting enzyme inhibitors. DESIGN AND METHODS:Streptozotocin-induced diabetic and control Spragu...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-199816110-00006
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:Fibromuscular dysplasia (FMD) and atherosclerotic renal artery stenosis (ARAS) are the most common causes of renovascular hypertension. So far, FMD is believed to cause hypertension via similar mechanisms as in ARAS, that is, a decrease in renal blood flow, which subsequently leads to increased renin secreti...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0000000000001243
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:Inherited differences in renal function underlie the effect of high salt diets on blood pressure in Dahl rats. We probed the kidneys of inbred Dahl SS/Jr and SR/Jr for anonymous and candidate genes whose expression was regulated by dietary sodium. METHODS:mRNA quantitation of both candidate genes implicated ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/01.hjh.0000133719.94075.e2
更新日期：2004-08-01 00:00:00
abstract：OBJECTIVES:Studies regarding the effects of parity on blood pressure in later life produced conflicting results. The aim of our study is to analyse whether parity influences the prevalence of hypertension in perimenopausal and postmenopausal women. METHODS:One thousand perimenopausal and postmenopausal women (mean age...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32835c1742
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:In arteries, agonists such as acetylcholine release an endothelium-derived hyperpolarizing factor (EDHF) that is neither nitric oxide nor prostacyclin. OBJECTIVES:To examine the responses to acetylcholine in segments of forearm veins from patients with chronic renal failure who either had never received dia...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/00004872-200310000-00021
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND AND PURPOSE:The present study clarifies associations between stroke outcomes after intravenous tissue plasminogen activator (tPA) and blood pressure (BP) as well as heart rate (HR) profiles. METHODS:We assessed 125 patients with stroke who received tPA within 3 h of onset. We obtained baseline, mean, maximu...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32834a764e
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:Local atrial tissue angiotensin II (AngII) level is elevated in atrial fibrillation (AF), but the mechanism is unknown. We hypothesized that atrial myocytes express all components of the renin-angiotensin system (RAS) and investigated whether rapid depolarization alone is sufficient to increase paracrine Ang...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e3282f34a4a
更新日期：2008-03-01 00:00:00
abstract：:If ambulatory blood pressure measurement is not possible because the upper-arm circumference is so great that even the largest cuff provided with the monitor will not encircle the arm, satisfactory measurements can be obtained by applying a cuff to the forearm. ...
journal_title：Journal of hypertension
pub_type： 杂志文章
doi：10.1097/HJH.0b013e32834192ef
更新日期：2011-03-01 00:00:00
