Abstract：
:Dysfunctional reward from the pursuit of thinness presents a major challenge to recovery from Anorexia Nervosa (AN). We explore the neuroscientific basis of aberrant reward in AN, with the aim of generating novel hypotheses for translational investigation, and elucidate disease mechanisms to inform the development of targeted interventions. Relevant neuroimaging and behavioural studies are reviewed. These suggest that altered eating in AN may be a consequence of aberrant reward processing combined with exaggerated cognitive control. We consider evidence that such aberrant reward processing is reflected in the compulsive behaviours characterising AN, with substantial overlap in the neural circuits implicated in reward processing and compulsivity. Drawing on contemporary neuroscientific theories of substance dependence, processes underpinning the shift from the initially rewarding pursuit of thinness to extreme and compulsive weight control behaviours are discussed. It is suggested that in AN, weight loss behaviour begins as overtly rewarding, goal-directed and positively reinforced, but over time becomes habitual and increasingly negatively reinforced. Excessive habit formation is suggested as one underlying mechanism perpetuating compulsive behaviour. Ongoing research into the behavioural and neural basis of aberrant reward in AN is required to further elucidate mechanisms. We discuss clinical and transdiagnostic implications, and propose that future treatment innovation may benefit from the development of novel interventions targeting aberrant reward processing in AN.
journal_name
Behav Res Therjournal_title
Behaviour research and therapyauthors
Park RJ,Godier LR,Cowdrey FAdoi
10.1016/j.brat.2014.07.007subject
Has Abstractpub_date
2014-11-01 00:00:00pages
47-59eissn
0005-7967issn
1873-622Xpii
S0005-7967(14)00110-7journal_volume
62pub_type
杂志文章,评审abstract：:Patients suffering from anxiety disorders have been shown to infer danger on the basis of their anxiety responses "if I feel anxious, there must be danger." This tendency logically hampers the identification of false alarms and may thus act in a way to confirm the a priori threat value of the feared stimuli/situations...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2012.11.005
更新日期：2013-03-01 00:00:00
abstract：:The present study examined the underlying role of attention control and response time variability in explaining the relationship between anxiety and two commonly computed measures of attention bias variability: 'moving average' and 'trial-level bias score' measures. Participants (final n = 195) completed measures of a...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2020.103751
更新日期：2020-12-01 00:00:00
abstract：:The effects of diazepam was assessed on a number of measures of phobic anxiety. Snake-phobic subjects underwent two sessions on either diazepam or placebo in a crossover design. In addition to a habituation series, a slide with the phobic object was displayed as well as a live snake which subjects were asked to approa...
journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章
doi：10.1016/0005-7967(90)90078-w
更新日期：1990-01-01 00:00:00
abstract：:The purpose of the present research was to assess whether a psychoactive dose of caffeine would have differential affects on the mood dimensions of arousal versus feelings of pleasantness and whether these mood alterations would influence memory either by (1) the experience of arousal at learning and/or (2) altered an...
journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0005-7967(98)00190-9
更新日期：1999-09-01 00:00:00
abstract：:In a study designed to evaluate the impact of benzodiazepine use on the outcome of behaviour therapy, 91, severe, chronic agoraphobics (46 BDZ users and 45 non-users) were randomly allocated on a double-blind basis to in vivo exposure with low-dose diazepam (ED) or placebo (EP). Drug doses were adjusted on the basis o...
journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0005-7967(94)90113-9
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abstract：:Many patients with chronic pain also exhibit elevated levels of health anxiety. This study examined the effect of health anxiety on the use of safety-seeking behaviors (SSBs) in pain-provoking situations. Participants were 20 chronic back pain patients with high health anxiety (Group H), 20 with low health anxiety (Gr...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2007.05.004
更新日期：2007-12-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章,评审
doi：10.1016/0005-7967(93)90066-4
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journal_title：Behaviour research and therapy
pub_type： 杂志文章,meta分析
doi：10.1016/j.brat.2013.08.005
更新日期：2013-11-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2019.103414
更新日期：2019-08-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2017.05.002
更新日期：2017-08-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章
doi：10.1016/j.brat.2006.04.009
更新日期：2007-03-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2005.01.005
更新日期：2006-02-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章,评审
doi：10.1016/0005-7967(95)00075-5
更新日期：1996-04-01 00:00:00
abstract：:A rapid and effective treatment for specific phobias, in which the treatment is done in one single session, is described in detail. The treatment method consists of a combination of exposure in vivo and modeling. The short- and long-term outcome for a consecutive series of 20 patients are reported. Mean treatment time...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/0005-7967(89)90113-7
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:This study tested the hypotheses that interpretations of voices will be associated with distress linked to auditory hallucinations, and that patients experiencing hallucinations will exhibit higher levels of negative interpretations in comparison with non-patients. METHOD:The Interpretation of Voices Invent...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2003.08.009
更新日期：2004-11-01 00:00:00
abstract：:We examined the effects of training to approach or avoid novel animals on fear-related responses in children. Ninety-nine primary school children (9-12 years old) were instructed to repeatedly move a manikin toward or away from pictures of novel animals. The training produced more positive self-reported attitudes for ...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2011.06.005
更新日期：2011-10-01 00:00:00
abstract：:Intrusive anxiety-provoking thoughts are a core feature of obsessive-compulsive disorder (OCD). Recent research suggests that individuals use five different techniques of thought control including: distraction, punishment, re-appraisal, social control, and worry. The purpose of the present study was to examine the str...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/s0005-7967(97)00030-2
更新日期：1997-08-01 00:00:00
abstract：:The Body Project is a dissonance-based selective eating disorder prevention program with a broad evidence-base. The study sought to determine if previous findings regarding participant moderators replicate in an effectiveness trial under more real-world conditions. This study also had the novel aim of examining facili...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2014.08.004
更新日期：2014-10-01 00:00:00
abstract：:Recent literature has emphasized the importance of instituting procedures for preventing relapse in obsessive-compulsive disorder (OCD). This study presents data documenting the effect of a maintenance program on the long term (2-year) adjustment of a group of patients with OCD treated with exposure and response preve...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/s0005-7967(96)00105-2
更新日期：1997-04-01 00:00:00
abstract：:A Female Sexual Fantasy Questionnaire (FSFQ) was developed from factor analysis of ratings through which women indicated the erotic potency of fantasies depicting nominated sexual activities. Five dimensions of sexual fantasy (genital, sensual, sexual power, sexual suffering, forbidden sexual-activity themes) are asse...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/0005-7967(91)90046-6
更新日期：1991-01-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2008.12.006
更新日期：2009-03-01 00:00:00
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journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2006.08.001
更新日期：2007-07-01 00:00:00
abstract：:The last few decades has seen psychological theories of chronic pain dominated by behavioural concepts and particularly, by the operant model as described by Fordyce et al. (1968: Fordyce, W., Fowler, R., & DeLateur, B. (1968) An application of behavior modification technique to a problem of chronic pain. Behaviour Re...
journal_title：Behaviour research and therapy
pub_type： 杂志文章,评审
doi：10.1016/s0005-7967(00)00061-9
更新日期：2001-07-01 00:00:00
abstract：:Outpatient medication adherence is a major problem, especially for patients repeatedly hospitalized for psychiatric disorders. This study included 39 such patients who were receiving case management services from a community mental health center. Patients were matched and randomly assigned to receive in a single sessi...
journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0005-7967(98)00036-9
更新日期：1998-09-01 00:00:00
abstract：:The objective of this study was to investigate the effect of a positive 'mood for sex' on genital and subjective sexual arousal in functional women, using a musical mood induction procedure. Fifty-one female Ss were randomly assigned to one of four conditions: erotic film preceded by mood induction; erotic fantasy pre...
journal_title：Behaviour research and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0005-7967(94)00059-s
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:Psychological flexibility theory (PFT) suggests three key processes of change: increases in value-directed behaviors, reduction in struggle with symptoms, and reduction in suffering. We hypothesized that Acceptance and Commitment Therapy (ACT) would change these processes and that increases in valued action ...
journal_title：Behaviour research and therapy
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brat.2017.01.013
更新日期：2017-04-01 00:00:00
abstract：:Social phobics exhibit an attentional bias for threat in probe detection and probe discrimination paradigms. Attention training programs, in which probes always replace nonthreatening cues, reduce attentional bias for threat and self-reported social anxiety. However, researchers have seldom included behavioral measure...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2011.10.005
更新日期：2012-01-01 00:00:00
abstract：:The present study investigated whether disgust-valenced information has an impact on children's fear beliefs about animals. Non-clinical children aged between 9 and 13 years (n=159) were presented with disgust-related and cleanliness-related information about unknown animals (Australian marsupials). Before and after i...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/j.brat.2007.09.005
更新日期：2008-01-01 00:00:00
abstract：:Using a validated and DSM-IV compatible questionnaire, the present study related family history of excessive social anxiety to social phobia and avoidant personality disorder (APD) in epidemiologically identified probands in the general population. Probands met diagnostic criteria for social phobia with or without APD...
journal_title：Behaviour research and therapy
pub_type： 杂志文章
doi：10.1016/s0005-7967(00)00003-6
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:The effectiveness of a combined methylphenidate/behavioural treatment (BT) versus methylphenidate-only for Chinese children with Attention-Deficit/Hyperactivity Disorder (ADHD) was tested in routine clinical practice in Hong Kong. METHODS:A randomized group comparison design was adopted with two treatment c...
journal_title：Behaviour research and therapy
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brat.2008.06.007
更新日期：2008-09-01 00:00:00
