Abstract:
:The flow of information from the outside to the inside of bacterial cells is largely directed by protein kinases. In addition to histidine/aspartate phosphorelays of two-component response regulators, recent work in Mycobacterium tuberculosis (Mtb) reinforces the idea that phosphorylation on serine (Ser), threonine (Thr) and tyrosine (Tyr) is central to bacterial physiology and pathogenesis, and that the corresponding phosphosystems are highly similar to those in eukaryotes. In this way, eukaryotes are a useful guide to understanding Ser/Thr/Tyr phosphorylation (O-phosphorylation) in prokaryotes such as Mtb. However, as novel functions and components of bacterial O-phosphorylation are identified, distinct differences between pro- and eukaryotic phosphosignalling systems become apparent. The emerging picture of O-phosphorylation in Mtb is complicated, goes beyond the eukaryotic paradigms, and shows the limitations of viewing bacterial phosphosignalling within the confines of the 'eukaryotic-like' model. Here, we summarize recent findings about Ser/Thr and the recently discovered Tyr phosphorylation pathways in Mtb, highlight the similarities and differences between eukaryotic and prokaryotic O-phosphorylation, and pose additional questions about signalling components, pathway organization, and ultimately, the cellular roles of O-phosphorylation in Mtb physiology and pathogenesis.
journal_name
Mol Microbioljournal_title
Molecular microbiologyauthors
Sherman DR,Grundner Cdoi
10.1111/mmi.12747subject
Has Abstractpub_date
2014-10-01 00:00:00pages
231-41issue
2eissn
0950-382Xissn
1365-2958journal_volume
94pub_type
杂志文章,评审abstract::Pathogenic enterotoxigenic Escherichia coli (ETEC) are the major bacterial cause of diarrhea in young children in developing countries and in travelers, causing significant mortality in children. Adhesive fimbriae are a prime virulence factor for ETEC, initiating colonization of the small intestinal epithelium. Simila...
journal_title:Molecular microbiology
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journal_title:Molecular microbiology
pub_type: 杂志文章,已发布勘误,评审
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journal_title:Molecular microbiology
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journal_title:Molecular microbiology
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journal_title:Molecular microbiology
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更新日期:2013-12-01 00:00:00
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更新日期:2014-11-01 00:00:00
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Molecular microbiology
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
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