Localization of 3H-estradiol-17beta in diethylstilbestrol-induced adenosis.

Abstract:

:Treatment of neonatal mice with diethylstilbestrol results in the appearance of adenosis in the uterine cervix and upper part of the vagina in later life. Using dry mount autoradiography, the uptake and distribution of [3H]-estradiol in the same regions were studied after in vivo injections with [3H]-estradiol. It was demonstrated that the adenosis cells have the ability of uptake and nuclear concentration of estradiol and are thus target cells for estrogens. The importance of this finding for the development of malignancy is discussed in relation to the clear cell adenocarcinomas in young women exposed to diethylstilbestrol in utero.

journal_name

Obstet Gynecol

authors

Kalland T,Fossberg TM,Forsberg JG

doi

10.1097/00006250-197804000-00016

subject

Has Abstract

pub_date

1978-04-01 00:00:00

pages

464-7

issue

4

eissn

0029-7844

issn

1873-233X

journal_volume

51

pub_type

杂志文章
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    authors: Arias F

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    authors: Morrison I,Olsen J

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    journal_title:Obstetrics and gynecology

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    journal_title:Obstetrics and gynecology

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    authors: Cederqvist LL,Ekelund L,Litwin SD

    更新日期:1980-04-01 00:00:00

  • Preterm premature rupture of membranes and the rate of neonatal sepsis after two courses of antenatal corticosteroids.

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  • Preinduction cervical ripening with prostaglandin E2 intracervical gel.

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    pub_type: 临床试验,杂志文章

    doi:

    authors: Laube DW,Zlatnik FJ,Pitkin RM

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  • Anal sphincter function after delivery rupture.

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    pub_type: 杂志文章

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  • Surgical management of acute diverticulitis in women.

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    doi:

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    更新日期:1981-11-01 00:00:00

  • Placental Abruption With Delayed Fetal Compromise in Maternal Acetaminophen Toxicity.

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    doi:

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  • A new technique for reduction of prolapsed fetal membranes for emergency cervical cerclage.

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    doi:

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    更新日期:2015-04-01 00:00:00

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