Toluene abuse during pregnancy: obstetric complications and perinatal outcomes.

Abstract:

:Toxic vapor abuse during pregnancy was found to be associated with increased maternal and fetal morbidity. Toluene-induced renal tubular acidosis occurred in over half of these women and was clustered among long-duration abusers. The renal acidosis placed the mother at risk for hypokalemia, with associated cardiac dysrhythmias and rhabdomyolysis. Beta-mimetics and intravenous fluid for preterm labor therapy potentially exacerbated the electrolyte abnormalities. Among 21 newborns exposed to toluene in utero, preterm delivery, perinatal death, and growth retardation were significantly increased. Delivery during uncorrected maternal acidosis further compromised these infants. As children, growth retardation and developmental delay were common findings. Recognition of the unique obstetric and medical characteristics of the toluene-abusing woman is needed if complications are to be averted and perinatal outcomes improved.

journal_name

Obstet Gynecol

authors

Wilkins-Haug L,Gabow PA

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

504-9

issue

4

eissn

0029-7844

issn

1873-233X

journal_volume

77

pub_type

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