Abstract：
BACKGROUND:Merkel cell carcinoma (MCC) is a neuroendocrine malignant neoplasm that usually has its primary location on the skin. It often metastasizes to lymph nodes, liver, lungs, bones and brain. Actually there have been few cases of MCC of the retroperitoneal region without a primary skin lesion. CASE PRESENTATION:Our case is a male of 55 year old who initially underwent a partial resection (R1) of a bulky pelvic mass; the histopathological analysis and the immunoistochemistry showed the presence of neuroendocrine Merkel cells. The patient underwent 6 cycles of postoperative chemotherapy (carbon platinum and etoposide) and adjuvant radiotherapy. Afterwards the patient underwent surgery again with the complete resection of the tumour. DISCUSSION:The histopatological and immunoistochemistry analysis of the first and the second surgical samples confirmed the diagnosis of a retroperitoneal high-grade neuroendocrine carcinoma with a high mitosis index. The immunoistochemistry profile showed neoplastic cell with: CD 20+, synaptophysin +, TTF-1-, neurofilaments +, CK 7-, chromogranin, Ki67 90%. In the patient's medical history no skin localizations were mentioned. CONCLUSION:The hypothesis of a MCC with a primary retroperitoneal localization has been strength by the histopathological and immunoistochemistry analysis of two intra-operative samples from two different surgical procedure and from the absence of either a primary skin location or of secondary recurrences. Is therefore reinforced the theory that from a cell into a retroperitoneal lymph node can arise a retroperitoneal mass originating a Merkel cell tumour.
journal_name
Ann Ital Chirjournal_title
Annali italiani di chirurgiaauthors
Pio Evoli L,Marino E,Rosati E,Ricci P,Graziosi L,Cavazzoni E,Donini Asubject
Has Abstractpub_date
2014-03-01 00:00:00pages
189-94issue
2eissn
0003-469Xissn
2239-253Xpii
S0003469X14020727journal_volume
85pub_type
杂志文章abstract：:Primary aortoenteric fistulas (PAEF) are rare entities associated with a high mortality. Although several causes have been reported, their occurrence is usually due to erosion of an abdominal aortic aneurysm into the intestinal tract. The most common sites for the fistula are the third and fourth portions of duodenum....
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：:Hereditary spherocytosis (HS) is a common inherited hemolytic anemia caused by a defective erythrocyte cellular membrane. Irrespective of type of surgery performed, several case reports comparing the two type of procedures, have not proven any significant difference between serum bilirubin, serum hemoglobin, red blood...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2018-07-11 00:00:00
abstract：AIM OF THE STUDY:The Authors intend to guide the choice of surgical treatment for mammary asymmetry, according to specific form of asymmetry. MATERIAL AND METHODS:Possible types of symmetryzation surgery are listed. First Author's personal technique is described and some clinical cases are presented. DISCUSSION:Regar...
journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
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doi：
更新日期：2018-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 临床试验,杂志文章
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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journal_title：Annali italiani di chirurgia
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更新日期：2017-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2019-01-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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journal_title：Annali italiani di chirurgia
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doi：
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journal_title：Annali italiani di chirurgia
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doi：
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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journal_title：Annali italiani di chirurgia
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doi：
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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journal_title：Annali italiani di chirurgia
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doi：
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journal_title：Annali italiani di chirurgia
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pub_type： 临床试验,杂志文章
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,随机对照试验
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章,评审
doi：
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journal_title：Annali italiani di chirurgia
pub_type： 杂志文章
doi：
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