Development of blood coagulation--a fetal lamb model.

abstract：:A number of neuromuscular diseases are associated with molecular defects in the mitochondrial DNA (mtDNA). These include: 1) a missense mutation at nucleotide 11778 in the mtDNA of Leber's hereditary optic neuropathy patients; 2) a heterogeneous array of deletions in the mtDNA of ocular myopathy patients; and 3) small...

journal_title：Pediatric research

authors： Wallace DC,Lott MT,Lezza AM,Seibel P,Voljavec AS,Shoffner JM

更新日期：1990-11-01 00:00:00

abstract：:The mitochondria play a major role in the regulation of intracellular calcium. Despite the fact that the enterocytes receive the majority of absorbed calcium, the role of the intestinal mitochondria in calcium transport during maturation is not known. Therefore, the current studies were designed to characterize calciu...

journal_title：Pediatric research

authors： Kikuchi T,Kikuchi K,Arab N,Ghishan FK

更新日期：1989-01-01 00:00:00

abstract：:The objective was to investigate any possible relationship between functional and structural vascular changes in women with low gestational age and/or low birth weight by analyzing the retinal vascular pattern in women with thoroughly documented blood pressure. Retinal vessel morphology was evaluated by digital image ...

journal_title：Pediatric research

authors： Kistner A,Jacobson L,Jacobson SH,Svensson E,Hellstrom A

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:The genetic basis of dysfunctional immune responses in necrotizing enterocolitis (NEC) remains unknown. We hypothesized that variants in nucleotide binding and oligomerization domain (NOD)-like receptors (NLRs) and autophagy (ATG) genes modulate vulnerability to NEC. METHODS:We genotyped a multi-center coho...

journal_title：Pediatric research

authors： Sampath V,Bhandari V,Berger J,Merchant D,Zhang L,Ladd M,Menden H,Garland J,Ambalavanan N,Mulrooney N,Quasney M,Dagle J,Lavoie PM,Simpson P,Dahmer M

更新日期：2017-04-01 00:00:00

abstract：:In the fetal rat, nitrofen induces congenital diaphragmatic hernia (CDH) and pulmonary vascular remodeling similar to what is observed in the human condition. Airway hyperactivity is common in infants with CDH and attributed to the ventilator-induced airway damage. The purpose of this study was to test the hypothesis ...

journal_title：Pediatric research

authors： Belik J,Davidge ST,Zhang W,Pan J,Greer JJ

更新日期：2003-05-01 00:00:00

abstract：:We hypothesized that fetal pancreatic digestive enzymes play a role in the lung damage after meconium aspiration. We studied the effect of meconium on the A549 alveolar epithelial cell line. The exposure of the cells to 0.5 to 5% meconium resulted in significant disruption of connections between A549 cells and caused ...

journal_title：Pediatric research

authors： Ivanov VA,Gewolb IH,Uhal BD

更新日期：2010-09-01 00:00:00

abstract：:Cell-based therapies hold significant promise for infants at risk for cerebral palsy (CP) from perinatal brain injury (PBI). PBI leading to CP results from multifaceted damage to neural cells. Complex developing neural networks are injured by neural cell damage plus unique perturbations in cell signaling. Given that c...

journal_title：Pediatric research

authors： Jantzie LL,Scafidi J,Robinson S

更新日期：2018-01-01 00:00:00

abstract：:Continuous EEG monitoring has not been used widely in neonatal intensive care, especially in the care of extremely premature infants, probably in part because of a lack of a reliable quantitative method. The purpose of this study was to quantify the EEG of the very premature infants just after birth by using spectral ...

journal_title：Pediatric research

authors： Victor S,Appleton RE,Beirne M,Marson AG,Weindling AM

更新日期：2005-03-01 00:00:00

abstract：:A strongly positive tuberculin skin reaction (> 1.5 cm2) was observed during the acute phase of the illness in 11 children with Kawasaki disease (KD), but not in control pediatric patients with other febrile infections (41 patients) or diseases similar to KD (9 patients). The cutaneous sensitivity to intermediate stre...

journal_title：Pediatric research

authors： Bertotto A,Spinozzi F,Vagliasindi C,Radicioni M,De Rosa O,Vaccaro R

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Severe traumatic brain injury (TBI) is a leading cause of mortality in children, but the accurate prediction of outcomes at the point of admission remains very challenging. Admission laboratory results are a promising potential source of prognostic data, but have not been widely explored in paediatric cohort...

journal_title：Pediatric research

authors： Kayhanian S,Young AMH,Mangla C,Jalloh I,Fernandes HM,Garnett MR,Hutchinson PJ,Agrawal S

更新日期：2019-11-01 00:00:00

abstract：:Reduced expression of bone morphogenetic protein receptors (BMPR) has been implicated in the pathogenesis of pulmonary hypertension (PH), but changes in the intracellular signaling pathway of BMPR have not been fully understood. We hypothesized that BMPR signaling in pulmonary endothelial cells is altered during the d...

journal_title：Pediatric research

authors： Takahashi K,Kogaki S,Matsushita T,Nasuno S,Kurotobi S,Ozono K

更新日期：2007-04-01 00:00:00

abstract：:A sensitive and rapid high-performance liquid chromatography method for determining lecithin/sphingomyelin (L/S) ratios in small volume tracheal aspirates has been evaluated in 115 infants sampled within 3 h of delivery. Respiratory distress syndrome was present in 41 infants and all had L/S ratios of less than or equ...

journal_title：Pediatric research

authors： D'Costa M,Dassin R,Bryan H

更新日期：1987-08-01 00:00:00

abstract：:To study the effects of podocyte injury on glomerular maturation and underlying mechanisms of such effects, puromycin aminonucleoside (PAN) was given to neonatal mice at 1 d post partum (1 dpp). Mice with PAN injection had smaller kidney weight (KW) and body weight (BW) at all times and smaller KW/BW at 4, 8, and 12 d...

journal_title：Pediatric research

authors： Ma J,Rossini M,Yang HC,Zuo Y,Fogo AB,Ichikawa I

更新日期：2007-10-01 00:00:00

abstract：:Lung deposition of inhaled drugs in ventilated neonates has been studied in models of questionable relevance. With conventional nebulizers, pulmonary deposition has been limited to 1% of the total dose. The objective of this study was to assess lung delivery of aerosols in a model of neonatal ventilation using a conve...

journal_title：Pediatric research

authors： Dubus JC,Vecellio L,De Monte M,Fink JB,Grimbert D,Montharu J,Valat C,Behan N,Diot P

更新日期：2005-07-01 00:00:00

abstract：:A dietary-related deficiency of docosahexaenoic acid [C22:6(n-3)] in infant cerebral cortex has been identified. Absence or very low rates of hepatic synthesis from the essential fatty acid precursor, alpha-linolenic acid [C18:3(n-3)], in early life may have been a contributory factor. We have analyzed liver total lip...

journal_title：Pediatric research

authors： Farquharson J,Jamieson EC,Logan RW,Patrick WJ,Howatson AG,Cockburn F

更新日期：1995-09-01 00:00:00

abstract：:There is in vitro evidence that the ductus venosus of the fetal and newborn lamb relaxes to administration of E-series prostaglandins. We performed this study to determine whether the ductus venosus of the newborn lamb could be reopened by an infusion of prostaglandin E1. Fifteen lambs between 4 and 28 h of life and s...

journal_title：Pediatric research

authors： Morin FC 3rd

更新日期：1987-03-01 00:00:00

abstract：:Hereditary surfactant protein B (SP-B) deficiency has been lethal in the first year of life without lung transplantation. We tested the hypothesis that SP-B gene mutations may result in milder phenotypes by investigating the mechanisms for lung disease in two children with less severe symptoms than have been previousl...

journal_title：Pediatric research

authors： Dunbar AE 3rd,Wert SE,Ikegami M,Whitsett JA,Hamvas A,White FV,Piedboeuf B,Jobin C,Guttentag S,Nogee LM

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to determine whether small-for-gestational-age (SGA) infants born very prematurely had increased respiratory morbidity in the neonatal period and at follow-up. METHODS:Data were examined from infants recruited into the United Kingdom Oscillation Study (UKOS). Of the 797 infants who...

journal_title：Pediatric research

authors： Peacock JL,Lo JW,D'Costa W,Calvert S,Marlow N,Greenough A

更新日期：2013-04-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of constant light in a neonatal care unit on the development of the sleep-and-wakefulness rhythm in preterm infants. Two groups of infants (57 preterm infants without other complications and 58 healthy term infants) were prospectively studied over infancy by a da...

journal_title：Pediatric research

authors： Shimada M,Segawa M,Higurashi M,Akamatsu H

更新日期：1993-02-01 00:00:00

abstract：:Extracellular glutathione peroxidase (E-GPx) is a selenoenzyme that reduces hydrogen peroxide and organic peroxides. All plasma glutathione peroxidase (GPx) activity in humans is attributable to E-GPx. The gastrointestinal (GI) tract also synthesizes and secretes E-GPx into the extracellular milieu. Endogenously gener...

journal_title：Pediatric research

authors： Tham DM,Whitin JC,Cohen HJ

更新日期：2002-05-01 00:00:00

abstract：:Pseudohypoaldosteronism is a hereditary salt-wasting syndrome usually seen in infancy with weight loss, dehydration, and failure to thrive. The pathophysiologic origin of pseudohypoaldosteronism is unknown. The defect could be related to the unresponsiveness of target organs to mineralocorticoids resulting in hyponatr...

journal_title：Pediatric research

authors： Bistritzer T,Evans S,Cotariu D,Goldberg M,Aladjem M

更新日期：1994-03-01 00:00:00

abstract：:Adverse perinatal events affecting cerebral functions are a major cause of neonatal mortality, morbidity, and long-term neurologic deficit. Intrapartum fetal EEG, which records fetal brain electrical activity, provides a monitoring modality for evaluating the fetal CNS during labor. In this study, we describe a new ap...

journal_title：Pediatric research

authors： Thaler I,Boldes R,Timor-Tritsch I

更新日期：2000-09-01 00:00:00

abstract：:WT1 is located on the short arm of human chromosome 11 and consists of 10 coding exons. Mutations of this gene have been reported to be the cause of Wilms' tumor, congenital male genitourinary malformations, and/or renal disorders. We describe here a novel WT1 gene mutation, i.e. a point mutation at intron 7 (+2) in b...

journal_title：Pediatric research

authors： Sakamoto J,Takata A,Fukuzawa R,Kikuchi H,Sugiyama M,Kanamori Y,Hashizume K,Hata JI

更新日期：2001-09-01 00:00:00

abstract：:Gaucher disease, the most common of the sphingolipidoses, results from the inherited deficiency of the enzyme glucocerebrosidase (EC 3.2.1.45). Although type 2 (acute neuronopathic) Gaucher disease is associated with rapidly progressive and fatal neurologic deterioration, the pathophysiologic mechanisms leading to the...

journal_title：Pediatric research

authors： Orvisky E,Sidransky E,McKinney CE,Lamarca ME,Samimi R,Krasnewich D,Martin BM,Ginns EI

更新日期：2000-08-01 00:00:00

abstract：:Intratracheal lipopolysaccharide (LPS) causes acute inflammation and injurious mechanical ventilation results in pulmonary and systemic inflammation. We aimed to determine in preterm lungs if continuous positive airway pressure (CPAP) protects against pulmonary and systemic inflammation, compared with conventional mec...

journal_title：Pediatric research

authors： Polglase GR,Hillman NH,Ball MK,Kramer BW,Kallapur SG,Jobe AH,Pillow JJ

更新日期：2009-01-01 00:00:00

abstract：:Platelet volume was measured in 20 healthy children, 18 patients with acute idiopathic thrombocytopenic purpura (ITP), 24 patients with chronic ITP, 22 patients with aplastic anemia, and 17 patients with acute leukemia in childhood. The authors compared the platelet volume of these patients by use of peak platelet vol...

journal_title：Pediatric research

authors： Tomita E,Akatsuka JI,Kokubun Y

更新日期：1980-02-01 00:00:00

abstract：:Carlo Agostoni, MD, and Kwang Sik Kim, MD, are the Guest Editors for this annual review issue on Nutrition and the Microbiome. Dr Agostoni is a Professor of Pediatrics at the Department of Clinical Sciences and Community Health, University of Milan, within the Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, ...

journal_title：Pediatric research

authors： Agostoni C,Kim KS

更新日期：2015-01-01 00:00:00

abstract：:The worldwide burden of disease due to Epstein-Barr virus (EBV) infection is enormous. Diseases include endemic Burkitt lymphoma, infectious mononucleosis, cancers after transplantation, Hodgkin lymphoma, and nasopharyngeal carcinoma. A prophylactic EBV vaccine has the potential to significantly reduce the incidence a...

journal_title：Pediatric research

authors： Balfour HH Jr,Schmeling DO,Grimm-Geris JM

更新日期：2020-01-01 00:00:00

abstract：:New information is emerging concerning the influence of environmental factors (e.g., viruses, pollutants, nutrients) on fetal lung development and the prenatal modulation of cellular and molecular effectors essential to the control of airway function, which may shed new light into the pathogenesis of chronic obstructi...

journal_title：Pediatric research

authors： Piedimonte G,Harford TJ

更新日期：2020-01-01 00:00:00

abstract：:Stimulation of cutaneous thermoreceptors may be an important factor in the initiation of continuous breathing at birth. Maintenance of a patent airway is also important in the continuation of effective ventilation after birth, but whereas in the adult the principal pharyngeal dilator is the genioglossus muscle, in the...

journal_title：Pediatric research

authors： Johnston BM,Gunn TR,Gluckman PD

更新日期：1988-03-01 00:00:00