Hypoxia induces alteration of bone morphogenetic protein receptor signaling in pulmonary artery endothelial cell.

abstract：BACKGROUND:Subgaleal hemorrhage (SGH) is reported to be associated with severe hemodynamic instability, coagulopathy, and even mortality. The importance of the presence or absence of neonatal encephalopathy in predicting SGH outcomes has not been explored. The aim of this study was to determine the relationship of clin...

journal_title：Pediatric research

authors： El-Dib M,Parziale MP,Johnson L,Benson CB,Grant PE,Robinson J,Volpe JJ,Inder T

更新日期：2019-08-01 00:00:00

abstract：:Twenty-two reported cases of neuroblastoma missed by the mass screening programs were reviewed (six cases in Sapporo City where a quantitative measurement for both vanillylmandelic acid (VMA) and homovanillic acid (HVA) is used and 16 cases in the districts of qualitative judgment only for VMA), and some potential fac...

journal_title：Pediatric research

authors： Nishi M,Miyake H,Takeda T,Takasugi N,Sato Y,Hanai J,Kawai T

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Mevalonate kinase deficiency (MKD) is a rare genetic autoinflammatory disease caused by blocking of the enzyme mevalonate kinase in the pathway of cholesterol and isoprenoids. The pathogenic mechanism originating an immune response in MKD patients has not been clearly understood. METHODS:We investigated the...

journal_title：Pediatric research

authors： Marcuzzi A,Zanin V,Kleiner G,Monasta L,Crovella S

更新日期：2013-09-01 00:00:00

abstract：:Sequential magnitude and the rate of change in tracheal mechanics after application of intermittent positive pressure (IPP), and the time constant, tau, of this deformation were determined in fetal (21 and 27 days gestation), neonatal (term, 31 days gestation) and adult rabbits. In vitro tracheal mechanics were determ...

journal_title：Pediatric research

authors： Bhutani VK,Shaffer TH

更新日期：1982-10-01 00:00:00

abstract：:We established an experimental animal model of the gastrointestinal colonization and systemic disease following oral challenge of type III group B streptococcal strain in 3-day-old newborn rats. Two type III group B streptococcal strains isolated from the cerebrospinal fluid of septic newborn infants produced coloniza...

journal_title：Pediatric research

authors： Kim KS,Dunn K,McGeary SA,Stiehm ER

更新日期：1984-12-01 00:00:00

abstract：:C3H/HeJ mice develop an increase in terminal air space area detectable by postnatal d 14 that persists into adulthood compared with strain-matched controls (C3H/SnJ, C3H/OuJ). Morphometric quantification revealed a 50% increase in terminal air space area by postnatal d 14 and a 2.3-fold increase by 2 mo of age in C3H/...

journal_title：Pediatric research

authors： Sampath V,Davis K,Senft AP,Richardson TR,Kitzmiller JA,Berclaz PY,Korfhagen TR

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Kawasaki disease was well known for coronary artery abnormalities with few reports of incidence of acute kidney injury (AKI). Our aim was to identify the rate of AKI in patients with Kawasaki disease and its associated factors. METHODS:All patients with Kawasaki disease admitted to a medical center from Feb...

journal_title：Pediatric research

authors： Chuang GT,Tsai IJ,Lin MT,Chang LY

更新日期：2016-08-01 00:00:00

abstract：:Left ventricular (LV) output nearly triples at birth, in association with increases in serum catecholamines. Similar increases in catecholamines in utero, however, do not increase output. We hypothesized that catecholamines increase contractility in utero, but that output cannot increase until LV loading conditions ar...

journal_title：Pediatric research

authors： Berning RA,Klautz RJ,Teitel DF

更新日期：1997-01-01 00:00:00

abstract：:Response characteristics of a transcutaneous PO2 electrode to step changes in PaO2 were determined. In vitro lag time and 95% response time of a transcutaneous PO2 monitor were compared to in vivo response. Release of arterial occlusion was used to produce rapid local PaO2 changes in human infants and adults. In vitro...

journal_title：Pediatric research

authors： Abu-Osba YK,Thach BT,Brouillette RT

更新日期：1981-02-01 00:00:00

abstract：:Pesticides are chemicals that are designed specifically for the purpose of killing or suppressing another living organism. Human toxicity is possible with any pesticide, and a growing body of literature has investigated possible associations with neurodevelopmental disorders. Attention deficit disorder with or without...

journal_title：Pediatric research

authors： Roberts JR,Dawley EH,Reigart JR

更新日期：2019-01-01 00:00:00

abstract：:The field of regenerative medicine continues to make substantial advancements in therapeutic strategies addressing urologic diseases. Tissue engineering borrows principles from the fields of cell biology, materials science, transplantation and engineering in an effort to repair or replace damaged tissues. This review ...

journal_title：Pediatric research

authors： Yamzon JL,Kokorowski P,Koh CJ

更新日期：2008-05-01 00:00:00

abstract：:Time-corrected measurements of transplacental and transamniotic electrical potentials were made in potassium-deficient rats on the 20th day of gestation. These averaged 6.4 mV and 2.0 mV, respectively, in the deficient group as compared with 14.3 and 18.4, respectively, in the controls. The measured maternal potassium...

journal_title：Pediatric research

authors： Fantel AG

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Though prenatal antidepressant exposure has been associated with adverse developmental outcomes, the extent to which the effects are due to prenatal drug exposure or underlying maternal mood disturbances is unclear. METHODS:This was a population-based retrospective cohort study using administrative data fro...

journal_title：Pediatric research

authors： Park M,Hanley GE,Guhn M,Oberlander TF

更新日期：2020-12-09 00:00:00

abstract：:An association between chorioamnionitis and periventricular leukomalacia has been reported in human preterm infants. However, whether this link is causal has not been convincingly established, and the underlying molecular mechanisms remain unclear. The objective of this study was to establish a reproducible model of c...

journal_title：Pediatric research

authors： Debillon T,Gras-Leguen C,Vérielle V,Winer N,Caillon J,Rozé JC,Gressens P

更新日期：2000-06-01 00:00:00

abstract：:We have previously shown that milk sensitization aggravates intestinal dysfunction in the malnourished guinea pigs, suggesting that it may also impair the recovery from malnutrition. To test this hypothesis, the growing guinea pigs were malnourished by feeding only maize for 7 d and then were refed for 21 d with a bal...

journal_title：Pediatric research

authors： Darmon N,Abdoul E,Roucayrol AM,Blaton MA,Briend A,Desjeux JF,Heyman M

更新日期：1998-12-01 00:00:00

abstract：:Serum diamine oxidase (DAO) activities were measured in 20 control patients and in 24 patients with gastroenteritis. Results (mean +/- SE) were as follows: 1) control patients (n = 20), 36.2 +/- 5.7 pmol h-1 ml-1; 2) gastroenteritis (acute phase) (n = 11), 31 +/- 4.9 pmol h-1 ml-1; 3) gastroenteritis (healing phase) (...

journal_title：Pediatric research

authors： Forget P,Saye Z,Van Cutsem JL,Dandrifosse G

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:A growing body of evidence defines inflammation as a hallmark feature of disease pathogenesis of Duchenne muscular dystrophy. To tailor potential immune modulatory interventions, a better understanding of immune dysregulation in Duchenne muscular dystrophy is needed. We now asked whether dystrophin deficienc...

journal_title：Pediatric research

authors： Kranig SA,Tschada R,Braun M,Patry C,Pöschl J,Frommhold D,Hudalla H

更新日期：2019-08-01 00:00:00

abstract：:The perinatal ontogeny of preprotachykinin-A gene expression was assessed in central respiration-related structures. On the day of birth, there was an enhanced expression of preprotachykinin-A mRNA in the region of the nucleus tractus solitarii, the primary relay station for respiratory and cardiovascular reflexes. Th...

journal_title：Pediatric research

authors： Srinivasan M,Yamamoto Y,Persson H,Lagercrantz H

更新日期：1991-04-01 00:00:00

abstract：:We studied the mechanisms by which C16:0 lysophosphatidylcholine (LPC) and albumin inhibit the surface activity of calf lung surfactant extract (CLSE) by using a pulsating bubble apparatus with a specialized hypophase exchange system, plus adsorption and Wilhelmy balance measurements. In the absence of inhibitors, CLS...

journal_title：Pediatric research

authors： Holm BA,Wang Z,Notter RH

更新日期：1999-07-01 00:00:00

abstract：:BackroundMicrocephaly can either be isolated or it may coexist with other neurological entities and/or multiple congenital anomalies, known as syndromic microcephaly. Although many syndromic cases can be classified based on the characteristic phenotype, some others remain uncertain and require further investigation. T...

journal_title：Pediatric research

authors： Tsoutsou E,Tzetis M,Giannikou K,Braoudaki M,Mitrakos A,Amenta S,Selenti N,Kanavakis E,Zafeiriou D,Kitsiou-Tzeli S,Fryssira H

更新日期：2017-08-01 00:00:00

abstract：:Bacterial sepsis is a relatively common problem in the neonatal period, particularly among prematurely delivered infants. The newborn rat has been widely used as a model for sepsis neonatorum, and in that model incomplete development of the neutrophil system has been postulated to be an important factor predisposing n...

journal_title：Pediatric research

authors： Christensen RD,Rothstein G

更新日期：1984-07-01 00:00:00

abstract：:To determine whether epidermal growth factor (EGF) or EGF-like transforming growth factors (TGFs) are present in ovine fetal tissues, we have tested acid-ethanol extracts of ovine fetal kidney for the ability to induce anchorage-independent growth of normal rat kidney fibroblasts in soft agar and to compete with 125I-...

journal_title：Pediatric research

authors： Freemark M,Comer M

更新日期：1987-11-01 00:00:00

abstract：:Ethanol consumption during pregnancy can cause fetal alcohol syndrome (FAS). Although the exact mechanism is unknown, nutritional alterations caused by ethanol exposure may be an etiologic factor in FAS. The congenital heart defects seen in FAS are similar to those found in vitamin A teratogenesis. Because ethanol ing...

journal_title：Pediatric research

authors： DeJonge MH,Zachman RD

更新日期：1995-04-01 00:00:00

abstract：:Values of IGF-I after extraction, its binding proteins, and the high affinity GH-binding protein (BP) are not well established in pediatric patients with insulin-dependent diabetes mellitus (IDDM). We report data for IGF-I, IGFBP-1, and -3, and GHBP in 92 Spanish children with IDDM, separated according to pubertal sta...

journal_title：Pediatric research

authors： Muñoz MT,Barrios V,Pozo J,Argente J

更新日期：1996-06-01 00:00:00

abstract：:Sex steroids accelerate bone maturation, but it is believed that estrogen action is needed for terminal epiphyseal fusion. In this study, we investigated the effects of a new estrogen-blocking agent, Faslodex (ICI 182,780), on estrogen-accelerated skeletal maturation in immature mice. On day-of-life 2 through 8, mice ...

journal_title：Pediatric research

authors： Gunther DF,Calikoglu AS,Underwood LE

更新日期：1999-09-01 00:00:00

abstract：:Alveolar hypoxia increases pulmonary artery pressure in lambs and sheep but increases lung lymph flow only in lambs; the reasons for this are unknown. To test the hypothesis that hypoxia-induced pulmonary venous constriction could in part explain the fluid filtration response in young lambs, eight young lambs (13 +/- ...

journal_title：Pediatric research

authors： Hazinski TA,Kennedy KA

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Increasing numbers of preterm-born children survive nowadays, and improving long-term health and neurodevelopment is becoming more important. Early-life growth has been linked to neurodevelopmental outcomes. We aimed to study whether this association has changed with time. METHODS:We studied two cohorts of ...

journal_title：Pediatric research

authors： Ruys CA,Hollanders JJ,Bröring T,van Schie PEM,van der Pal SM,van de Lagemaat M,Lafeber HN,Rotteveel J,Finken MJJ

更新日期：2019-02-01 00:00:00

abstract：:The precise mechanism by which the most common cause of bacterial enterocolitis in humans, Campylobacter jejuni, perturbs the intestinal mucosa remains elusive. To define effects of C. jejuni infection on mucosal permeability, Madin-Darby canine kidney (MDCK)-I and T84 cell monolayers were infected with C. jejuni for ...

journal_title：Pediatric research

authors： Wine E,Chan VL,Sherman PM

更新日期：2008-12-01 00:00:00

abstract：:The ability of erythrocytes from newborn babies and adults to maintain reduced glutathione levels during oxidative stress was studied. In vitro incubation of erythrocytes with H2O2, with or without inactivation of catalase, caused a rapid depletion of reduced glutathione (GSH) and concomitant accumulation of oxidized ...

journal_title：Pediatric research

authors： Clahsen PC,Moison RM,Holtzer CA,Berger HM

更新日期：1992-10-01 00:00:00

abstract：:Sleep organization of infants may be influenced by differences in nutrient intakes from human milk and formula. Because sleep/awake and sleep stage patterns affect energy expenditure, we hypothesized that differences in sleep organization between breast-fed and formula-fed infants might account in part for differences...

journal_title：Pediatric research

authors： Butte NF,Jensen CL,Moon JK,Glaze DG,Frost JD Jr

更新日期：1992-11-01 00:00:00