Higher incidence of Epstein-Barr virus-induced lymphocyte transformation in multiple sclerosis.

Abstract:

OBJECTIVES:Epstein-Barr virus (EBV) infection is associated with multiple sclerosis (MS), and EBV may transform lymphoblastoid cell lines more frequently in MS patients than controls, but it is not clear whether this reflects a higher viral load or an enhanced ability to reactivate EBV. MATERIAL AND METHODS:MS patients and controls were examined for their B-cell subsets and during 16 weeks for spontaneous lymphocyte transforming events. RESULTS:MS patients had normal distribution of B-cell subsets, but a significantly higher incidence of B-cell transforming events, which occurred with kinetics similar to controls. CONCLUSIONS:The higher incidence suggests an increased frequency of latent EBV-infected B cells in MS.

journal_name

Acta Neurol Scand

authors

Tørring C,Andreasen C,Gehr N,Bjerg L,Petersen T,Höllsberg P

doi

10.1111/ane.12249

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

90-6

issue

2

eissn

0001-6314

issn

1600-0404

journal_volume

130

pub_type

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