Building on a tradition of ethical consideration of the dead.


:Medical culture espouses patient interaction based on detached concern, where emotional attachment to patients is attenuated to preserve objectivity. The body is viewed as nonliving matter in motion. Alternatively, the cadaver may be considered a gift. To receive so awesome a gift is an extraordinary privilege; acknowledgment of this gift affirms our interconnectedness with our community and offers a way to provide for its betterment. Gift exchange establishes a relationship between donor and recipient, and the absence of an assigned worth leaves open the cycle of giving and receiving for future exchanges. Inherent within undertaking a dissection lies an obligation that the gift not be wasted. Donating one's body for dissection meets the criteria for the highest levels of charity as set forth by the 12th-century philosopher, physician, and rabbinic scholar Moses Maimonides. Preserving the anonymity of cadavers protects students as well by enabling them to dissect in an environment that respects the sensitive and difficult nature of the work. Maimonides provides support for formalizing the anonymous relationship between student and cadaver. The anonymous nature of the gift provides enormous latitude for using the skills thus gained to serve one's patients and to benefit the common good.


Hum Pathol


Human pathology


Sukol RB




Has Abstract


1995-07-01 00:00:00














  • Support for p63 expression as an adverse prognostic marker in Merkel cell carcinoma: report on a Canadian cohort.

    abstract::Recent evidence has invoked immunohistochemical expression of p63 in Merkel cell carcinoma as an adverse prognostic factor. Conflicting data led us to evaluate this. An Eastern Canadian cohort diagnosed between 1990 and 2012 was studied. Demographic and clinical data were obtained from pathology records and Provincial...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Fleming KE,Ly TY,Pasternak S,Godlewski M,Doucette S,Walsh NM

    更新日期:2014-05-01 00:00:00

  • Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis.

    abstract::We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Milne AN,Sitarz R,Carvalho R,Polak MM,Ligtenberg M,Pauwels P,Offerhaus GJ,Weterman MA

    更新日期:2007-06-01 00:00:00

  • Overexpression of BCAT1 is a prognostic marker in gastric cancer.

    abstract::As one form of branched-chain amino-acid transaminase (BCAT) enzymes, It has been found that up-regulation of BCAT1 is associated with poor prognosis in numerous types of tumors, but studies on the role of BCAT1 expression in gastric cancer (GC) are rare. The aims of this study were to detect BCAT1 expression in GC an...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Xu Y,Yu W,Yang T,Zhang M,Liang C,Cai X,Shao Q

    更新日期:2018-05-01 00:00:00

  • Clinicopathologic significance of immunostaining of α-thalassemia/mental retardation syndrome X-linked protein and death domain-associated protein in neuroendocrine tumors.

    abstract::α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are speci...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Chen SF,Kasajima A,Yazdani S,Chan MS,Wang L,He YY,Gao HW,Sasano H

    更新日期:2013-10-01 00:00:00

  • Aberrant copy numbers of ALK gene is a frequent genetic alteration in neuroblastomas.

    abstract::A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Subramaniam MM,Piqueras M,Navarro S,Noguera R

    更新日期:2009-11-01 00:00:00

  • Pathologic features of lung biopsy specimens from influenza pneumonia cases.

    abstract::Most histopathologic descriptions of influenza pneumonia are based on autopsy findings in fatal cases during epidemics and pandemics of influenza. We describe the histologic findings of influenza pneumonia observed in biopsy material derived from six sporadic cases of influenza (influenza A, four cases; influenza B, o...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yeldandi AV,Colby TV

    更新日期:1994-01-01 00:00:00

  • Polypoid urothelial tumor with inverted growth pattern in the renal pelvis: morphologic and molecular characteristics of a unique diagnostic entity.

    abstract::We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIPs) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. Thirteen cases were identified...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Wobker SE,Zhong M,Epstein JI

    更新日期:2017-01-01 00:00:00

  • Orbital osteoclastoma of apparent extraskeletal origin in a pagetic patient: a case report.

    abstract::A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparen...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Pecorella I,Ciardi A,Amadeo G,Baiocchini A,Marasco A,Di Tondo U

    更新日期:2000-12-01 00:00:00

  • Florid basal cell hyperplasia of the prostate: a histological, ultrastructural, and immunohistochemical analysis.

    abstract::Basal cell proliferation is a common finding in a benign hyperplastic prostate gland. Occasionally, basal cell hyperplasia is so florid that it can be mistaken for prostatic adenocarcinoma. We characterized histological, ultrastructural, and immunohistochemical features of florid basal cell hyperplasia from transureth...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yang XJ,Tretiakova MS,Sengupta E,Gong C,Jiang Z

    更新日期:2003-05-01 00:00:00

  • Identification of immunophenotypic subtypes with different prognoses in extranodal natural killer/T-cell lymphoma, nasal type.

    abstract::To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yu JB,Zuo Z,Zhang WY,Yang QP,Zhang YC,Tang Y,Zhao S,Mo XM,Liu WP

    更新日期:2014-11-01 00:00:00

  • Clinicopathologic findings in patients with infantile hemiparesis and epilepsy.

    abstract::Infantile hemiparesis may be associated with significant morbidity and may have a profound impact on a child's physical and social development. There are little published data evaluating the clinicopathologic features of patients with infantile hemiparesis. The present study retrospectively examines these clinicopatho...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Prayson RA,Hannahoe BM

    更新日期:2004-06-01 00:00:00

  • The activated nerve growth factor receptor p-TrkA is selectively expressed in advanced-stage ovarian carcinoma.

    abstract::The objective of this study was to compare the expression of the nerve growth factor (NGF) receptors TrkA and p75 in ovarian borderline tumors, International Federation of Gynecology and Obstetrics (FIGO) stage I carcinomas and advanced-stage (FIGO stage III-IV) carcinomas, and to assess a possible association between...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Ødegaard E,Staff AC,Abeler VM,Kopolovic J,Onsrud M,Lazarovici P,Davidson B

    更新日期:2007-01-01 00:00:00

  • DNA ploidy of fibrolamellar hepatocellular carcinoma by image analysis.

    abstract::Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Orsatti G,Greenberg PD,Rolfes DB,Ishak KG,Paronetto F

    更新日期:1994-09-01 00:00:00

  • A combination of GATA3 and SOX10 is useful for the diagnosis of metastatic triple-negative breast cancer.

    abstract::In metastatic breast cancer (MBC), it can be difficult to establish the origin if the primary tumor is triple negative or if there is a loss of biomarker expression. SOX10 expression has been reported in primary triple-negative breast cancer but is poorly studied in metastatic lesions. In this study, the diagnostic ut...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Tozbikian GH,Zynger DL

    更新日期:2019-03-01 00:00:00

  • Discordance in the histopathologic diagnosis of melanoma and melanocytic nevi between expert pathologists.

    abstract::The reliability of a diagnostic test depends on the reproducibility of the result. Many clinical diagnostic tests can be quantified with established ranges and standard deviations. Other tests are more subjective, such as those that depend on analysis of a visual image with an increased possibility of variance in the ...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Farmer ER,Gonin R,Hanna MP

    更新日期:1996-06-01 00:00:00

  • DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.

    abstract::Previous studies have found a link between high expression levels of the Deleted in Split hand/Split foot 1 (DSS1) gene and cancer progression. The aim of this study was to examine whether overexpression of DSS1 is a feature of melanoma and squamous cell carcinoma (SCC) and if any epigenetic modifications are involved...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Venza M,Visalli M,Catalano T,Beninati C,Teti D,Venza I

    更新日期:2017-02-01 00:00:00

  • CD30-positive anaplastic large cell lymphoma in a human T-cell lymphotropic virus-I endemic area.

    abstract::Clinicopathological and cytogenetic studies were performed on specimens from 43 patients with CD30-positive anaplastic large cell lymphoma (ALCL). All patients were born and lived in a human T-cell lymphotropic virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum anti-HTLV-I antibody suggesting the prese...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Takeshita M,Ohshima K,Akamatsu M,Ohgami A,Kikuchi M,Suzumiya J,Uike N,Okamura T,Nakayama J

    更新日期:1995-06-01 00:00:00

  • Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34betaE12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung.

    abstract::Basaloid carcinoma (BC) and large-cell neuroendocrine carcinoma (LCNEC) are 2 recently recognized variants of large-cell lung carcinomas that may overlap in their morphology, and are discriminated by expression of neuroendocrine markers in LCNEC. Because thyroid transcription factor 1 (TTF-1) is expressed in lung aden...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Sturm N,Lantuéjoul S,Laverrière MH,Papotti M,Brichon PY,Brambilla C,Brambilla E

    更新日期:2001-09-01 00:00:00

  • Endometrial patterns during therapy with danazol or gestrinone for endometriosis: structural and ultrastructural study.

    abstract::We treated 36 women with laparoscopically proven endometriosis with danazol 600 mg/d (n = 17) or gestrinone 5.0 mg/wk (n = 19) for 6 months. Endometrial samples were obtained before and at 3 and 6 months of treatment and were studied by light, scanning, and transmission electron microscopy. At 3 months of treatment, t...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Marchini M,Fedele L,Bianchi S,Di Nola G,Nava S,Vercellini P

    更新日期:1992-01-01 00:00:00

  • Expression of matrix metalloproteinases 2 and 7 in tumor cells correlates with the World Health Organization classification subtype and clinical stage of thymic epithelial tumors.

    abstract::To investigate the roles of matrix metalloproteinases (MMPs) in thymic epithelial tumors, we examined the expression of MMP-2, -7, and -9; membrane-type 1 (MT1)-MMP; and tissue inhibitor of metalloproteinase-2 (TIMP-2) in 57 tumors by immunohistochemistry and in selected 15 cases by in situ hybridization. The tumors c...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Takahashi E,Tateyama H,Akatsu H,Fukai I,Yamakawa Y,Fujii Y,Eimoto T

    更新日期:2003-12-01 00:00:00

  • Colorectal diffuse large B-cell lymphoma: molecular subclassification and prognostic significance of immunoglobulin gene translocation.

    abstract::Primary colorectal diffuse large B-cell lymphoma (DLBCL) is rare, and its clinicopathological and genetic features are poorly understood. The aim of our study was to elucidate the frequency and prognostic significance of molecular subgroups in colorectal DLBCL. We examined 25 cases of colorectal lymphoma with DLBCL-li...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Hori Y,Yamamoto H,Nozaki Y,Torisu T,Fujiwara M,Taguchi K,Nishiyama K,Nakamura S,Kitazono T,Oda Y

    更新日期:2020-02-01 00:00:00

  • An ultrastructural and light microscopic study of the synovium in ochronotic arthropathy.

    abstract::The synovium in two well-documented cases of alkaptonuric ochronosis was studied by transmission electron and light microscopy. A feature of alkaptonuria previously unreported in the English-language literature was the presence of phagocytosis of large collagen fibrils by synovial macrophages in both cases. The origin...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Gaines JJ Jr,Tom GD,Khankhanian N

    更新日期:1987-11-01 00:00:00

  • Nonalcoholic steatohepatitis: a study of 49 patients.

    abstract::Nonalcoholic steatohepatitis (NASH) refers to an alcoholic hepatitis-like histologic pattern found in nonalcoholic patients. A review of 543 liver biopsies diagnosed as alcoholic hepatitis yielded 49 cases of NASH. The patients were commonly middle-aged women who were obese and often diabetic. NASH was usually discove...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Lee RG

    更新日期:1989-06-01 00:00:00

  • Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy.

    abstract::ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Larbcharoensub N,Leopairat J,Sirachainan E,Narkwong L,Bhongmakapat T,Rasmeepaisarn K,Janvilisri T

    更新日期:2008-06-01 00:00:00

  • Nuclear immunoreactivity of BLM-s, a proapoptotic BCL-2 family member, is specifically detected in salivary adenoid cystic carcinoma.

    abstract::Tumor cells frequently evade apoptosis triggered by cellular stress via aberrant regulation of the BCL-2 family members, which are key players in regulating cell death under physiological and pathological situations. Previously, we have identified a novel BH3-only protein of the BCL-2 family, BLM-s (BCL-2-like molecul...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Tsai MS,Hsieh MS,Huang HY,Huang PH

    更新日期:2019-02-01 00:00:00

  • Validation of a histopathologic classification scheme for antineutrophil cytoplasmic antibody-associated glomerulonephritis.

    abstract::Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Nohr E,Girard L,James M,Benediktsson H

    更新日期:2014-07-01 00:00:00

  • Immunohistochemical profile of high-grade urothelial bladder carcinoma and prostate adenocarcinoma.

    abstract::The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated form...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Mhawech P,Uchida T,Pelte MF

    更新日期:2002-11-01 00:00:00

  • Congenital nemaline myopathy with dilated cardiomyopathy: an autopsy study.

    abstract::A 3-year-old boy with congenital nemaline myopathy had generalized muscle weakness and hypotonia since birth. He developed cardiac symptoms at 2 years of age and died from congestive heart failure. At autopsy, the heart was markedly dilated, involving both ventricles. Rod bodies were recognized not only in skeletal mu...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Ishibashi-Ueda H,Imakita M,Yutani C,Takahashi S,Yazawa K,Kamiya T,Nonaka I

    更新日期:1990-01-01 00:00:00

  • Novel gene fusions in secretory carcinoma of the salivary glands: enlarging the ETV6 family.

    abstract::Secretory carcinoma (SC) of the salivary gland is a low-grade malignancy associated with a well-defined clinical, histologic, immunohistochemical, and cytogenetic signature. Although the t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion is well documented, advances in molecular profiling in saliv...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Guilmette J,Dias-Santagata D,Nosé V,Lennerz JK,Sadow PM

    更新日期:2019-01-01 00:00:00

  • Exploration of BRAFV600E as a diagnostic adjuvant in the non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP).

    abstract::The non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) are distinguished from classical papillary thyroid carcinoma with predominantly follicular architecture (CPTCPFA) by distinct histomorphologic and molecu...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Johnson DN,Sadow PM

    更新日期:2018-12-01 00:00:00