Building on a tradition of ethical consideration of the dead.


:Medical culture espouses patient interaction based on detached concern, where emotional attachment to patients is attenuated to preserve objectivity. The body is viewed as nonliving matter in motion. Alternatively, the cadaver may be considered a gift. To receive so awesome a gift is an extraordinary privilege; acknowledgment of this gift affirms our interconnectedness with our community and offers a way to provide for its betterment. Gift exchange establishes a relationship between donor and recipient, and the absence of an assigned worth leaves open the cycle of giving and receiving for future exchanges. Inherent within undertaking a dissection lies an obligation that the gift not be wasted. Donating one's body for dissection meets the criteria for the highest levels of charity as set forth by the 12th-century philosopher, physician, and rabbinic scholar Moses Maimonides. Preserving the anonymity of cadavers protects students as well by enabling them to dissect in an environment that respects the sensitive and difficult nature of the work. Maimonides provides support for formalizing the anonymous relationship between student and cadaver. The anonymous nature of the gift provides enormous latitude for using the skills thus gained to serve one's patients and to benefit the common good.


Hum Pathol


Human pathology


Sukol RB




Has Abstract


1995-07-01 00:00:00














  • Epidermal growth factor receptor as an adverse survival predictor in squamous cell carcinoma of the penis.

    abstract::Penile carcinoma (PC) is more frequent in underdeveloped countries, generally is diagnosed at an advanced stage when therapeutic options are restricted, and thus is associated with high morbidity/mortality rates. Recent studies have demonstrated clinical benefits with epidermal growth factor receptor (EGFR)-targeted t...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Silva Amancio AM,Cunha IW,Neves JI,Quetz JD,Carraro DM,Rocha RM,Zequi SC,Cubilla AL,da Fonseca FP,Lopes A,Cunha MD,Lima MV,Vassallo J,Guimarães GC,Soares FA

    更新日期:2017-03-01 00:00:00

  • Comparison of estrogen receptor, progesterone receptor and HER2 results in concurrent ipsilateral samples with invasive breast carcinoma: a retrospective study of 246 biopsies from 119 patients.

    abstract::There is no consensus regarding biomarker testing on the ipsilateral breast carcinomas present in separate biopsies, irrespective of whether the biopsies are performed concurrently or consecutively. We aimed to investigate estrogen receptor (ER), progesterone receptor (PR) and HER2 concordance in ipsilateral concurren...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Singh K,Wang Y,Marketkar S,Kalife ET,Steinhoff MM

    更新日期:2017-07-01 00:00:00

  • Morphometric differentiation between responsive tumor cells and mesothelial hyperplasia in second-look operations for ovarian cancer.

    abstract::We developed a procedure based on computerized image analysis to establish objective criteria for the differential diagnosis between mesothelial hyperplasia and cancer in peritoneal tissue samples obtained at second-look operations for ovarian cancer. The tumor tissue after chemotherapy was classified as "nonresponsiv...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Deligdisch L,Kerner H,Cohen CJ,Dargent D,Gil J

    更新日期:1993-02-01 00:00:00

  • Bioassay of hormones.

    abstract::Bioassay of hormones has a small but important role in defining the physiologic status of selected patients in whom immunoassay results do not correlate with clinical signs and symptoms. This article reviews three sensitive bioassays for hormones, which are based on 1) stimulation of adenylate cyclase in membrane prep...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Klee GG

    更新日期:1984-02-01 00:00:00

  • Trefoil factor expression in normal and diseased human salivary glands.

    abstract::Trefoil factors are wound-healing peptides important in protection and healing of the human gastrointestinal tract. Their potential for therapy of gastrointestinal ulcers has been established. This study investigated the hypothesis that trefoil factors are also present in human salivary gland. Tissues from surgical bi...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Devine DA,High AS,Owen PJ,Poulsom R,Bonass WA

    更新日期:2000-04-01 00:00:00

  • Diagnosis of gastrointestinal stromal tumors: A consensus approach.

    abstract::As a result of major recent advances in understanding the biology of gastrointestinal stromal tumors (GISTs), specifically recognition of the central role of activating KIT mutations and associated KIT protein expression in these lesions, and the development of novel and effective therapy for GISTs using the receptor ...

    journal_title:Human pathology

    pub_type: 共识发展会议,杂志文章,评审


    authors: Fletcher CD,Berman JJ,Corless C,Gorstein F,Lasota J,Longley BJ,Miettinen M,O'Leary TJ,Remotti H,Rubin BP,Shmookler B,Sobin LH,Weiss SW

    更新日期:2002-05-01 00:00:00

  • Thyroid gland papillary carcinomas with "micropapillary pattern," a recently recognized poor prognostic finding: clinicopathologic and survival analysis of 7 cases.

    abstract::Micropapillary carcinoma is a histologic pattern, rather than an independent entity, that has an aggressive clinical behavior regardless of location. Histologically, it is characterized by papillary cell groups in clear spaces. The micropapillary pattern in the thyroid gland has not been studied until recently but und...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Lino-Silva LS,Domínguez-Malagón HR,Caro-Sánchez CH,Salcedo-Hernández RA

    更新日期:2012-10-01 00:00:00

  • Bone-marrow-derived CXCR4-positive tissue-committed stem cell recruitment in human right ventricular remodeling.

    abstract::The epicardium contributes to cardiac formation, particularly during embryogenesis. It remains to be seen if it is also involved in postnatal myocardial homeostasis. This study evaluates the topographic distribution of stem cells (c-Kit) and extracardiac progenitor cells (CXCR4+) and their contribution to ventricular ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Castellani C,Padalino M,China P,Fedrigo M,Frescura C,Milanesi O,Stellin G,Thiene G,Angelini A

    更新日期:2010-11-01 00:00:00

  • HMGB2 promotes the malignancy of human gastric cancer and indicates poor survival outcome.

    abstract::HMGB2 is an important protein in carcinogenesis. However, little is known about the specific role of HMGB2 in gastric cancer. In the present study, HMGB2 expression was evaluated in 198 primary gastric cancer tissues and their adjacent nontumor controls. The correlation between HMGB2 expression and clinico-pathologica...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Cui G,Cai F,Ding Z,Gao L

    更新日期:2019-02-01 00:00:00

  • Differential expression of alpha 6 and alpha 2 very late antigen integrins in the normal, hyperplastic, and neoplastic prostate: simultaneous demonstration of cell surface receptors and their extracellular ligands.

    abstract::The very late antigens (VLAs) are alpha beta-heterodimeric transmembrane proteins that include surface cell receptors for laminin (VLA-6) and collagen (VLA-2), which mediate cell-matrix and cell-cell adhesion. We investigated the distribution of VLA-6 (alpha 6, beta 1) and VLA-2 (alpha 2, beta 1) proteins in normal, h...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Bonkhoff H,Stein U,Remberger K

    更新日期:1993-03-01 00:00:00

  • Extramammary Paget's disease: analysis of growth signal pathway from the human epidermal growth factor receptor 2 protein.

    abstract::Paget's disease is a skin cancer characterized by characteristic (Paget) cells scattered in the epidermis. Although its prognosis is generally favorable with surgical resection, the clinical outcome turns unfavorable in cases with recurrence and metastasis. Therefore, establishment of effective therapeutic regimens is...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Ogawa T,Nagashima Y,Wada H,Akimoto K,Chiba Y,Nagatani T,Inayama Y,Yao M,Aoki I,Ikezawa Z

    更新日期:2005-12-01 00:00:00

  • Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas.

    abstract::The expression/activation of epidermal growth factor receptor (EGFR) and the correlation with the phosphorylation status of downstream modulator proteins, Akt, mammalian target of rapamycin (mTOR), p70S6-kinase (S6K), ribosomal protein S6 (rS6), and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), were anal...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Dobashi Y,Suzuki S,Kimura M,Matsubara H,Tsubochi H,Imoto I,Ooi A

    更新日期:2011-02-01 00:00:00

  • Ki67 labeling index in core needle biopsies independently predicts tumor-specific survival in prostate cancer.

    abstract::A better knowledge of the biological aggressiveness of individual tumors could facilitate the selection of treatment in prostate cancer patients. This study assesses the influence of histological and molecular features in core needle biopsy specimens of prostate cancer on tumor-specific survival. Formalin-fixed core n...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Bubendorf L,Tapia C,Gasser TC,Casella R,Grunder B,Moch H,Mihatsch MJ,Sauter G

    更新日期:1998-09-01 00:00:00

  • Cardiomyopathy and myocyte intranuclear inclusions in neuronal intranuclear inclusion disease: a case report.

    abstract::Neuronal intranuclear inclusion disease (NIID) is a progressive, usually fatal degenerative neurologic condition characterized by eosinophilic, intranuclear inclusions in neurons of the central and peripheral nervous system. We report a boy with onset of disease manifestations at age 3 and death at age 9, who showed c...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Oyer CE,Cortez S,O'Shea P,Popovic M

    更新日期:1991-07-01 00:00:00

  • IMP3 expression in biopsy specimens as a diagnostic biomarker for colorectal cancer.

    abstract::No single biological marker is used in routine diagnosis of colorectal cancer (CRC) in endoscopic biopsies. IMP3 is a good independent prognostic biomarker for CRC. However, the expression of IMP3 in hyperplastic polyp (HP) and adenoma has not yet been studied. Moreover, no studies have established the diagnostic valu...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Wei Q,Zhou H,Zhong L,Shi L,Liu J,Yang Q,Zhao T

    更新日期:2017-06-01 00:00:00

  • Clinicopathologic findings in patients with infantile hemiparesis and epilepsy.

    abstract::Infantile hemiparesis may be associated with significant morbidity and may have a profound impact on a child's physical and social development. There are little published data evaluating the clinicopathologic features of patients with infantile hemiparesis. The present study retrospectively examines these clinicopatho...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Prayson RA,Hannahoe BM

    更新日期:2004-06-01 00:00:00

  • Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma.

    abstract::We report here an exceptional pattern of atypical lentiginous melanocytic proliferation within an adenoma, leading to focal lamina propria infiltration and pulmonary metastasis, which was considered as primary colonic mucosal melanoma (MM) in a Caucasian patient. Such case illustrates the diagnosis criteria required t...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Furudoï A,Caumont C,Dutriaux C,Cappellen D,Goussot JF,Vergier B,Merlio C,Barberis C,Merlio JP,Gros A

    更新日期:2016-02-01 00:00:00

  • Is cervical screening working? A cytopathologist's view from the United Kingdom.

    abstract::This article considers the NHS cervical screening program and the controversies which have attended the introduction of comprehensive screening in a partially screened population of women in whom the underlying risk of disease was unknown. The increase in screening coverage which has taken place since 1988 has coincid...

    journal_title:Human pathology

    pub_type: 杂志文章,评审


    authors: Herbert A

    更新日期:1997-02-01 00:00:00

  • Sinonasal adenocarcinoma: evidence for histogenetic divergence of the enteric and nonenteric phenotypes.

    abstract::Adenocarcinomas of nonsalivary origin represent approximately 10% to 20% of all sinonasal malignancies and are characterized by varying histopathologic features and uncertain histogenesis. To better understand the histogenesis and phenotypic heterogeneity of these tumors, we performed immunohistochemical analyses for ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Choi HR,Sturgis EM,Rashid A,DeMonte F,Luna MA,Batsakis JG,El-Naggar AK

    更新日期:2003-11-01 00:00:00

  • Pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophagus.

    abstract::The aim of this study was to systematically investigate clinicopathologic features of the recently described pancreatic acinar-like adenocarcinoma of the proximal stomach invading the esophagus (n = 43). Patient median age was 66 years (range, 51-90 years). The male-to-female ratio was 7.6. Grossly, pancreatic acinar-...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Huang Q,Gold JS,Shi J,Fan X,Wu H,Feng A,Zhou Q

    更新日期:2012-06-01 00:00:00

  • Erythroleukemic infiltration of a lymph node: use of hemoglobin immunohistochemical techniques in diagnosis.

    abstract::Isolated submandibular adenopathy developed in a patient who had subacute erythroleukemia. Lymph node biopsy revealed a proliferation of immature cells and scattered foci of dyserythropoietic normoblasts. Since a review of the literature revealed no detailed description of an erythroleukemic lymph node infiltrate, a h...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Keifer J,Zaino R,Ballard JO

    更新日期:1984-11-01 00:00:00

  • A subset of small cell lung cancer with low neuroendocrine expression and good prognosis: a comparison study of surgical and inoperable cases with biopsy.

    abstract::Patients with small cell lung carcinoma (SCLC) rarely demonstrate long-term survival. We previously reported that gene expression profiling identified a subset of SCLC with good prognosis in surgical cases. To find an easier way to routinely identify SCLC belonging to this subset, we conducted the present study with a...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Hamanaka W,Motoi N,Ishikawa S,Ushijima M,Inamura K,Hatano S,Uehara H,Okumura S,Nakagawa K,Nishio M,Horai T,Aburatani H,Matsuura M,Iwasaki A,Ishikawa Y

    更新日期:2014-05-01 00:00:00

  • Diseases transmitted by blood transfusion.

    abstract::Except for post-transfusion hepatitis (PTH), the transmission of disease by blood transfusion appears to be very limited. There are only a few case reports documenting the transmission of malaria and other parasitic diseases, syphilis, or bacterial infections. The ability to eradicate PTH will depend on the developmen...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Kahn RA

    更新日期:1983-03-01 00:00:00

  • Renal insufficiency secondary to 2,8-dihydroxyadenine urolithiasis.

    abstract::A 48-year-old man with a history of recurrent urolithiasis and chronic renal failure underwent a nephrectomy for a renal mass. At surgery the mass proved to be a calculus impacted in a dilated calyx. Gross examination of the kidney revealed chalky white deposits in the deep medulla and papillary tips. Histologic exami...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Gelb AB,Fye KH,Tischfield JA,Sahota AS,Sparks JW,Hancock DC,Sibley RK

    更新日期:1992-09-01 00:00:00

  • Immunohistologic analysis of small lymphocytic infiltrates of the orbit and conjunctiva.

    abstract::In a prior study we reported that monotypic immunoglobulin expression significantly correlated with an increased risk of dissemination by small lymphocytic infiltrates (SLIs) of the orbit and conjunctiva. However, less than half of all monotypic SLIs disseminated. In this study, we applied a large panel of monoclonal ...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Medeiros LJ,Harris NL

    更新日期:1990-11-01 00:00:00

  • A comparative assessment of proliferating cell nuclear antigen, c-myc p62, and nucleolar organizer region staining in non-Hodgkin's lymphomas: a histochemical and immunohistochemical study of 200 cases.

    abstract::Proliferating cell nuclear antigen (PCNA) and c-myc p62 oncoprotein are two nuclear proteins expressed in proliferating and transformed cells. They can be recognized immunohistochemically in paraffin sections by the monoclonal antibodies PC-10 and c-myc 1-9E10, respectively. On the other hand, nucleolar organizer regi...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Korkolopoulou P,Patsouris E,Pangalis G,Tsenga A,Elemenoglou J,Thomas-Tsangli E,Spandidos D,Kittas C

    更新日期:1993-04-01 00:00:00

  • Epithelioid hemangioendothelioma of the liver: an ultrastructural study.

    abstract::Epithelioid hemangioendotheliomas are uncommon vascular tumors, mainly observed in lung and soft tissues. Liver involvement is infrequent and, in contrast to the extrahepatic localizations of the tumor, has not been subjected to detailed ultrastructural analysis. This prompted us to report the results of the ultrastru...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Scoazec JY,Degott C,Reynes M,Benhamou JP,Feldmann G

    更新日期:1989-07-01 00:00:00

  • Genotypic and immunohistological demonstration of the progression of an unusual reactive-like B-cell lymphoproliferative disorder to a high grade diffuse lymphoma.

    abstract::In the present study the clinical and pathological evolution of a reactive-like B-cell lymphoproliferative disorder with an unusually high content of T cells is described. Immunogenotypic analysis showed that the same phenotypically atypical B-cell clone, characterized by the unusual presence of an immunoglobulin (Ig)...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Dolcetti R,De Re V,Carbone A,De Vita S,Gloghini A,Tirelli U,Pasquotti B,Boiocchi M

    更新日期:1995-03-01 00:00:00

  • Involvement of 2p23 in pulmonary inflammatory pseudotumors.

    abstract::Pulmonary inflammatory pseudotumors (IP) are rare mesenchymal proliferations that have a polymorphic histology and an unpredictable biologic behavior. The histologic spectrum of IP has led to uncertainty as to whether this tumor has a reactive or neoplastic pathogenesis. Reports of extrapulmonary IP have identified cl...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yousem SA,Shaw H,Cieply K

    更新日期:2001-04-01 00:00:00

  • Identification of biomarkers to distinguish clear cell sarcoma from malignant melanoma.

    abstract::Clear cell sarcoma is a rare and malignant soft tissue tumor that shows phenotypic and immunohistochemical overlap with cutaneous malignant melanoma; identification of biomarkers that differentiate clear cell sarcoma from malignant melanoma is therefore needed. In this study, we performed mutation analysis of BRAF and...

    journal_title:Human pathology

    pub_type: 杂志文章


    authors: Yang L,Chen Y,Cui T,Knösel T,Zhang Q,Geier C,Katenkamp D,Petersen I

    更新日期:2012-09-01 00:00:00