Abstract：
:Medical culture espouses patient interaction based on detached concern, where emotional attachment to patients is attenuated to preserve objectivity. The body is viewed as nonliving matter in motion. Alternatively, the cadaver may be considered a gift. To receive so awesome a gift is an extraordinary privilege; acknowledgment of this gift affirms our interconnectedness with our community and offers a way to provide for its betterment. Gift exchange establishes a relationship between donor and recipient, and the absence of an assigned worth leaves open the cycle of giving and receiving for future exchanges. Inherent within undertaking a dissection lies an obligation that the gift not be wasted. Donating one's body for dissection meets the criteria for the highest levels of charity as set forth by the 12th-century philosopher, physician, and rabbinic scholar Moses Maimonides. Preserving the anonymity of cadavers protects students as well by enabling them to dissect in an environment that respects the sensitive and difficult nature of the work. Maimonides provides support for formalizing the anonymous relationship between student and cadaver. The anonymous nature of the gift provides enormous latitude for using the skills thus gained to serve one's patients and to benefit the common good.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Sukol RBdoi
10.1016/0046-8177(95)90216-3subject
Has Abstractpub_date
1995-07-01 00:00:00pages
700-5issue
7eissn
0046-8177issn
1532-8392pii
0046-8177(95)90216-3journal_volume
26pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Recent evidence has invoked immunohistochemical expression of p63 in Merkel cell carcinoma as an adverse prognostic factor. Conflicting data led us to evaluate this. An Eastern Canadian cohort diagnosed between 1990 and 2012 was studied. Demographic and clinical data were obtained from pathology records and Provincial...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.12.008
更新日期：2014-05-01 00:00:00
abstract：:We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.12.010
更新日期：2007-06-01 00:00:00
abstract：:As one form of branched-chain amino-acid transaminase (BCAT) enzymes, It has been found that up-regulation of BCAT1 is associated with poor prognosis in numerous types of tumors, but studies on the role of BCAT1 expression in gastric cancer (GC) are rare. The aims of this study were to detect BCAT1 expression in GC an...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.02.003
更新日期：2018-05-01 00:00:00
abstract：:α-Thalassemia/mental retardation syndrome X-linked protein (ATRX) and death domain-associated protein (DAXX) genes are tumor suppressors whose mutations have been identified in sporadic pancreatic neuroendocrine tumors as well as in patients with MEN1. However, it is unknown whether ATRX and DAXX alterations are speci...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.04.025
更新日期：2013-10-01 00:00:00
abstract：:A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2009.05.002
更新日期：2009-11-01 00:00:00
abstract：:Most histopathologic descriptions of influenza pneumonia are based on autopsy findings in fatal cases during epidemics and pandemics of influenza. We describe the histologic findings of influenza pneumonia observed in biopsy material derived from six sporadic cases of influenza (influenza A, four cases; influenza B, o...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90170-8
更新日期：1994-01-01 00:00:00
abstract：:We report 13 cases of unique polypoid urothelial tumors with inverted growth pattern (PUTIPs) occurring in the proximal ureter and renal pelvis. We describe their morphologic features and further characterize them in regard to TERT promoter mutation status and microsatellite instability. Thirteen cases were identified...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.07.030
更新日期：2017-01-01 00:00:00
abstract：:A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparen...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2000.20411
更新日期：2000-12-01 00:00:00
abstract：:Basal cell proliferation is a common finding in a benign hyperplastic prostate gland. Occasionally, basal cell hyperplasia is so florid that it can be mistaken for prostatic adenocarcinoma. We characterized histological, ultrastructural, and immunohistochemical features of florid basal cell hyperplasia from transureth...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(03)00121-7
更新日期：2003-05-01 00:00:00
abstract：:To analyze the differentiation characteristics of extranodal natural killer/T-cell lymphoma, nasal type, one nude mouse model, cell lines SNK6 and SNT8, and 16 fresh human samples were analyzed by flow cytometry immunophenotyping and immunohistochemistry staining; and 115 archived cases were used for phenotypic detect...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.04.024
更新日期：2014-11-01 00:00:00
abstract：:Infantile hemiparesis may be associated with significant morbidity and may have a profound impact on a child's physical and social development. There are little published data evaluating the clinicopathologic features of patients with infantile hemiparesis. The present study retrospectively examines these clinicopatho...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2004.02.013
更新日期：2004-06-01 00:00:00
abstract：:The objective of this study was to compare the expression of the nerve growth factor (NGF) receptors TrkA and p75 in ovarian borderline tumors, International Federation of Gynecology and Obstetrics (FIGO) stage I carcinomas and advanced-stage (FIGO stage III-IV) carcinomas, and to assess a possible association between...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.06.027
更新日期：2007-01-01 00:00:00
abstract：:Twelve cases of fibrolamellar hepatocellular carcinoma (FLC) were evaluated for DNA ploidy by means of image analysis of Feulgen-stained tissue sections. All of the tumors showed a nondiploid DNA distribution (six aneuploid and six tetraploid); no diploid pattern was found. The nuclear area of the tumors (53.8 microns...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(94)90015-9
更新日期：1994-09-01 00:00:00
abstract：:In metastatic breast cancer (MBC), it can be difficult to establish the origin if the primary tumor is triple negative or if there is a loss of biomarker expression. SOX10 expression has been reported in primary triple-negative breast cancer but is poorly studied in metastatic lesions. In this study, the diagnostic ut...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.11.005
更新日期：2019-03-01 00:00:00
abstract：:The reliability of a diagnostic test depends on the reproducibility of the result. Many clinical diagnostic tests can be quantified with established ranges and standard deviations. Other tests are more subjective, such as those that depend on analysis of a visual image with an increased possibility of variance in the ...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(96)90157-4
更新日期：1996-06-01 00:00:00
abstract：:Previous studies have found a link between high expression levels of the Deleted in Split hand/Split foot 1 (DSS1) gene and cancer progression. The aim of this study was to examine whether overexpression of DSS1 is a feature of melanoma and squamous cell carcinoma (SCC) and if any epigenetic modifications are involved...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.10.018
更新日期：2017-02-01 00:00:00
abstract：:Clinicopathological and cytogenetic studies were performed on specimens from 43 patients with CD30-positive anaplastic large cell lymphoma (ALCL). All patients were born and lived in a human T-cell lymphotropic virus (HTLV)-I endemic area. Twenty-one patients (48.8%) had serum anti-HTLV-I antibody suggesting the prese...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90165-5
更新日期：1995-06-01 00:00:00
abstract：:Basaloid carcinoma (BC) and large-cell neuroendocrine carcinoma (LCNEC) are 2 recently recognized variants of large-cell lung carcinomas that may overlap in their morphology, and are discriminated by expression of neuroendocrine markers in LCNEC. Because thyroid transcription factor 1 (TTF-1) is expressed in lung aden...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2001.27110
更新日期：2001-09-01 00:00:00
abstract：:We treated 36 women with laparoscopically proven endometriosis with danazol 600 mg/d (n = 17) or gestrinone 5.0 mg/wk (n = 19) for 6 months. Endometrial samples were obtained before and at 3 and 6 months of treatment and were studied by light, scanning, and transmission electron microscopy. At 3 months of treatment, t...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90011-q
更新日期：1992-01-01 00:00:00
abstract：:To investigate the roles of matrix metalloproteinases (MMPs) in thymic epithelial tumors, we examined the expression of MMP-2, -7, and -9; membrane-type 1 (MT1)-MMP; and tissue inhibitor of metalloproteinase-2 (TIMP-2) in 57 tumors by immunohistochemistry and in selected 15 cases by in situ hybridization. The tumors c...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2003.07.013
更新日期：2003-12-01 00:00:00
abstract：:Primary colorectal diffuse large B-cell lymphoma (DLBCL) is rare, and its clinicopathological and genetic features are poorly understood. The aim of our study was to elucidate the frequency and prognostic significance of molecular subgroups in colorectal DLBCL. We examined 25 cases of colorectal lymphoma with DLBCL-li...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2019.09.003
更新日期：2020-02-01 00:00:00
abstract：:The synovium in two well-documented cases of alkaptonuric ochronosis was studied by transmission electron and light microscopy. A feature of alkaptonuria previously unreported in the English-language literature was the presence of phagocytosis of large collagen fibrils by synovial macrophages in both cases. The origin...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(87)80385-4
更新日期：1987-11-01 00:00:00
abstract：:Nonalcoholic steatohepatitis (NASH) refers to an alcoholic hepatitis-like histologic pattern found in nonalcoholic patients. A review of 543 liver biopsies diagnosed as alcoholic hepatitis yielded 49 cases of NASH. The patients were commonly middle-aged women who were obese and often diabetic. NASH was usually discove...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/0046-8177(89)90249-9
更新日期：1989-06-01 00:00:00
abstract：:ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2007.10.009
更新日期：2008-06-01 00:00:00
abstract：:Tumor cells frequently evade apoptosis triggered by cellular stress via aberrant regulation of the BCL-2 family members, which are key players in regulating cell death under physiological and pathological situations. Previously, we have identified a novel BH3-only protein of the BCL-2 family, BLM-s (BCL-2-like molecul...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.09.005
更新日期：2019-02-01 00:00:00
abstract：:Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.017
更新日期：2014-07-01 00:00:00
abstract：:The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated form...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.129416
更新日期：2002-11-01 00:00:00
abstract：:A 3-year-old boy with congenital nemaline myopathy had generalized muscle weakness and hypotonia since birth. He developed cardiac symptoms at 2 years of age and died from congestive heart failure. At autopsy, the heart was markedly dilated, involving both ventricles. Rod bodies were recognized not only in skeletal mu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90078-j
更新日期：1990-01-01 00:00:00
abstract：:Secretory carcinoma (SC) of the salivary gland is a low-grade malignancy associated with a well-defined clinical, histologic, immunohistochemical, and cytogenetic signature. Although the t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion is well documented, advances in molecular profiling in saliv...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.08.011
更新日期：2019-01-01 00:00:00
abstract：:The non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) are distinguished from classical papillary thyroid carcinoma with predominantly follicular architecture (CPTCPFA) by distinct histomorphologic and molecu...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2018.06.033
更新日期：2018-12-01 00:00:00
