Abstract：
:Medical culture espouses patient interaction based on detached concern, where emotional attachment to patients is attenuated to preserve objectivity. The body is viewed as nonliving matter in motion. Alternatively, the cadaver may be considered a gift. To receive so awesome a gift is an extraordinary privilege; acknowledgment of this gift affirms our interconnectedness with our community and offers a way to provide for its betterment. Gift exchange establishes a relationship between donor and recipient, and the absence of an assigned worth leaves open the cycle of giving and receiving for future exchanges. Inherent within undertaking a dissection lies an obligation that the gift not be wasted. Donating one's body for dissection meets the criteria for the highest levels of charity as set forth by the 12th-century philosopher, physician, and rabbinic scholar Moses Maimonides. Preserving the anonymity of cadavers protects students as well by enabling them to dissect in an environment that respects the sensitive and difficult nature of the work. Maimonides provides support for formalizing the anonymous relationship between student and cadaver. The anonymous nature of the gift provides enormous latitude for using the skills thus gained to serve one's patients and to benefit the common good.
journal_name
Hum Patholjournal_title
Human pathologyauthors
Sukol RBdoi
10.1016/0046-8177(95)90216-3subject
Has Abstractpub_date
1995-07-01 00:00:00pages
700-5issue
7eissn
0046-8177issn
1532-8392pii
0046-8177(95)90216-3journal_volume
26pub_type
杂志文章相关文献
HUMAN PATHOLOGY文献大全abstract：:Lymphangioleiomyomatosis (LAM) is a rare disease which afflicts young women of childbearing age. Recently, it has been listed as an indication for lung transplantation. We describe a case of recurrent LAM in a 31-year-old woman occurring in the allograft of a male donor after single lung transplantation. Nonisotopic i...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(97)90233-1
更新日期：1997-12-01 00:00:00
abstract：:After multiple fragmentation of neoplastic nuclei into "nucleotesimals," a recently discovered variety of amitosis, some fragments appear to be inflated to full nuclear size; other probably lyse, releasing nucleic acid, which may assist in the synthesis of new cytoplasm around newly formed nuclei. This observation may...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(82)80006-3
更新日期：1982-07-01 00:00:00
abstract：:The differential diagnosis between poorly differentiated prostate adenocarcinoma (PAC) involving the bladder and high-grade urothelial bladder cancer (UC) with prostate extension can be very challenging. The aim of this study is to evaluate the use of a panel of antibodies to distinguish the poorly differentiated form...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.129416
更新日期：2002-11-01 00:00:00
abstract：:Nuclear pore complexes (NPCs) are elaborate macromolecular structures that regulate the bidirectional nucleocytoplasmic traffic system. In vertebrate cells, NPCs include a family of 50 to 100 proteins termed nucleoporins (Nups). The 88-kD Nup has been found to be linked in a dynamic subcomplex with the oncogenic CAN/N...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/hupa.2002.124785
更新日期：2002-05-01 00:00:00
abstract：:Grb2-associated binder 2 protein (Gab2) is a member of scaffold proteins, playing crucial roles in (receptor-) tyrosine kinase and cytokine signaling. Chronic myeloid leukemia cells with t(9;22)(q34;q11) express the Bcr/Abl fusion protein, which interacts with Grb2 and Gab2 signaling, thereby triggering hematopoietic ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2010.09.012
更新日期：2011-05-01 00:00:00
abstract：:Malignant mixed tumors of the parotid gland are rare. Metastasizing lesions are even more rare. To the best of our knowledge, this is the first case reported in the English literature in which the scalp nodule was the primary manifestation of the malignant nature of the parotid tumor. ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(77)80100-7
更新日期：1977-11-01 00:00:00
abstract：:Although rare, synovial sarcoma (SS) is one of the most common soft tissue sarcomas affecting young adults. To investigate potential tumor markers related to synovial sarcoma prognosis, we carried out a single-institution retrospective analysis of 103 patients diagnosed with SS between 1980 and 2009. Clinical outcome ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.03.001
更新日期：2013-09-01 00:00:00
abstract：:Graduate training is one of the most important activities in which we engage. Through PhD training programs in pathology, we continually renew the intellectual vigor of our discipline and assure its position as a vibrant force in the life sciences. To focus on this important issue, the Education Committee of the Ameri...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/j.humpath.2004.03.014
更新日期：2004-07-01 00:00:00
abstract：:A case of metastatic malignant melanoma simulating a giant cell tumor of bone is reported. This case typifies the diversity of expression of malignant melanoma. Osteoclast-like giant cells were present only in the femoral head metastasis and were not present in the primary lesion. The giant cell component may be refle...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(90)90183-6
更新日期：1990-09-01 00:00:00
abstract：:Tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) antigenic sites were shown within the resident glomerular mesangial cells of lupus nephritis patients applying the colloidal gold immunocytochemical approach at the electron microscopic level. Using specific polyclonal antibodies against human recombinan...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(95)90253-8
更新日期：1995-05-01 00:00:00
abstract：:To establish whether an intramural left anterior descending coronary artery (LADA) is a simple anatomic or a singularly pathologic variant we studied 39 hearts, each with an intramural course of the LADA and no coronary artery disease, valvular derangement, cardiomyopathy, or congenital anomaly. Seventeen of the 39 he...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90004-z
更新日期：1993-07-01 00:00:00
abstract：:A 15 year old girl presented with a painful desquamative rash, fever, and profound hypotension. Despite antimicrobial therapy and intensive supportive measures, she died 80 hours after admission. The premortem skin biopsy and autopsy findings, which included subepidermal edema and blister formation, subacute vasculiti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(81)80237-7
更新日期：1981-01-01 00:00:00
abstract：:Oncogenes, growth factors, cell surface receptors, and cell-cycle and apoptotic regulatory proteins have been implicated in the growth regulation and progression of Barrett's-associated neoplasia. Among these, insulin-like growth factor 1 receptor (IGF1-R) and c-Src are reported to be key regulators of mitogenesis and...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1053/s0046-8177(03)00354-x
更新日期：2003-10-01 00:00:00
abstract：:In 2012, the lower anogenital squamous terminology (LAST) project introduced new nomenclature for human papillomavirus-related squamous lesions of the lower genital tract: low-grade and high-grade squamous intraepithelial lesion (LSIL and HSIL). Biomarker p16(INK4a) immunohistochemistry (IHC) was also recommended to a...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2016.04.010
更新日期：2016-09-01 00:00:00
abstract：:Antineutrophil cytoplasmic antibody-associated small-vessel vasculitides cause multiple organ system disease including rapidly progressive glomerulonephritis. Recently, Berden et al (J Am Soc Nephrol. 2010;21:1628-1636) proposed a new histopathologic classification scheme separating renal biopsies into 4 classes: foca...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2014.02.017
更新日期：2014-07-01 00:00:00
abstract：:Gastrointestinal stromal tumor (GIST) is the preferred term for mesenchymal tumors specific for the gastrointestinal tract (60% in stomach, 30% small intestine, 10% elsewhere). GISTs include most tumors previously designated as leiomyoma, cellular leiomyoma, leiomyoblastoma, and leiomyosarcoma. However, in the esophag...
journal_title：Human pathology
pub_type： 杂志文章,评审
doi：10.1016/s0046-8177(99)90040-0
更新日期：1999-10-01 00:00:00
abstract：:Viruses have long been held to be of pathogenetic importance in the evolution of autoimmune connective tissue disease. We describe 7 adults who developed cutaneous connective tissue disease stigmata in temporal association with recent cytomegalovirus (CMV) infection but without the classic cytopathic changes of CMV in...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.06.002
更新日期：2007-01-01 00:00:00
abstract：:This study aimed to determine the correlations of 7 histopathologic prognostic indicators of follicular lymphoma (follicular lymphoma grade, CD10 expression, Bcl-2 expression, IGH/BCL2 fusion, diffuse area, fibrosis, and marginal zone differentiation) with progression-free survival, overall survival, and follicular ly...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.06.013
更新日期：2013-11-01 00:00:00
abstract：:We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2006.12.010
更新日期：2007-06-01 00:00:00
abstract：:Heterotopic pancreatic parenchyma recapitulates the normal pancreas in extrapancreatic locations and, on rare occasions, can even give rise to pancreatic adenocarcinoma. The genetic signatures of pancreatic adenocarcinoma and its precursor lesions are well characterized. We explored the genetic alterations in precurso...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2015.09.023
更新日期：2016-02-01 00:00:00
abstract：:Four surgically resected cardiac valves received from three female patients showed the presence of acute and chronic rheumatic valvulitis. The material was studied by means of transmission and scanning electron microscopy. This is the first time that there has been an investigation of the ultrastructure in acute rheum...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(80)80109-2
更新日期：1980-01-01 00:00:00
abstract：:The presence of thyroglobulin (TG) was investigated by immunohistochemistry with one polyclonal and three distinct monoclonal anti-TG antibodies in 19 primary and 15 metastatic medullary thyroid carcinoma (MTC) cases. In two primary tumors possessing a mixed trabecular and follicular growth pattern, a significant numb...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(93)90035-f
更新日期：1993-03-01 00:00:00
abstract：:Phyllodes tumors are rare but clinically important fibroepithelial tumors of the breast. Both epithelial and stromal components actively interact with each other to participate in phyllodes tumor development. Accumulated evidence suggests that the Wnt signaling pathway is important in this stromal-epithelial interacti...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2012.03.028
更新日期：2012-12-01 00:00:00
abstract：:The proliferation marker mitotic activity index is the strongest prognostic indicator in lymph node-negative breast cancer. The World Health Organization (WHO) 2003-defined procedure for determining WHO-mitotic activity index is often replaced by a quick scan mitotic impression. We evaluated the prognostic consequence...
journal_title：Human pathology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.humpath.2007.08.016
更新日期：2008-04-01 00:00:00
abstract：:Aberrant crypt foci (ACF) are one of the earliest putative preneoplastic, and in some cases, neoplastic lesions in human colons. These microscopic lesions, identified on methylene blue-stained mucosa with a low-power-magnification microscope, are thought to be closely related to the earliest steps in multistage coloni...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/s0046-8177(98)90062-4
更新日期：1998-05-01 00:00:00
abstract：:Previous studies indicated that microRNA (miR)-675 and its precursor lncRNA H19 were both overexpressed in glioma tissues, and H19 might play an oncogenic role. To investigate the involvement of miR-675 in gliomas and its underlying mechanisms, we here collected candidate target genes of miR-675-5p from miRTarBase (ht...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.09.006
更新日期：2017-11-01 00:00:00
abstract：:Kaposi's sarcoma (KS) is a pleomorphic spindle cell lesion whose incidence has markedly increased among patients infected with the human immunodeficiency virus (HIV), especially among those whose primary risk factor is homo/bisexual transmission. The question as to whether KS is even a true neoplasm still remains larg...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/0046-8177(92)90112-g
更新日期：1992-03-01 00:00:00
abstract：:The use of prosthetic implants for breast augmentation has become commonplace. Although implants do not increase the risk of conventional mammary carcinoma, they are rarely associated with anaplastic large cell lymphoma. We report 2 cases of breast implant capsule-associated squamous cell carcinoma with poor clinical ...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.07.011
更新日期：2017-09-01 00:00:00
abstract：:Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is comm...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2017.10.036
更新日期：2018-02-01 00:00:00
abstract：:Human papillomavirus-related oropharyngeal squamous cell carcinoma has a unique biology and improved prognosis. A new focus is to identify prognostic biomarkers specifically in this human papillomavirus-positive cohort. We analyzed cyclin D1 immunostaining on a tissue microarray of patients with known clinical follow-...
journal_title：Human pathology
pub_type： 杂志文章
doi：10.1016/j.humpath.2013.01.021
更新日期：2013-08-01 00:00:00
