Vitamin D deficiency and coronary artery disease: a review of the evidence.


:Coronary artery disease remains the leading cause of death in developed countries despite significant progress in primary prevention and treatment strategies. Older patients are at particularly high risk of poor outcomes following acute coronary syndrome and impaired nutrition, including low vitamin D levels, may play a role. The extraskeletal effects of vitamin D, in particular, its role in maintaining a healthy cardiovascular system are receiving increased attention. Longitudinal studies have demonstrated increased cardiovascular mortality and morbidity associated with vitamin D deficiency. Low vitamin D levels have been linked to inflammation, higher coronary artery calcium scores, impaired endothelial function and increased vascular stiffness. However, so far, few randomized controlled trials have investigated the potential benefits of vitamin D supplementation in preventing cardiovascular events, and most available trials have tested low doses of supplementation in relatively low-risk populations. Whether vitamin D supplementation will be beneficial among patients with coronary artery disease, including high risk older patients presenting with acute coronary syndrome, is unknown and warrants further investigation.


Am Heart J


American heart journal


Kunadian V,Ford GA,Bawamia B,Qiu W,Manson JE




Has Abstract


2014-03-01 00:00:00














  • A new method for automated detection of the R-on-T phenomenon.

    abstract::The detection of premature ectopic beats coinciding with the T-wave of the antecedent beat is important for patient monitoring. In the method described here, the difficulties of direct measurement of QT time are avoided by evaluating the changes of QT time according to heart rate by use of a diode function generator. ...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Breithardt G,Loogen F,Schmiel FK,Seipel L

    更新日期:1975-06-01 00:00:00

  • Repeat coronary angioplasty during the same angiographic diagnosis of coronary restenosis.

    abstract::To determine whether any differences exist in results of treatment of restenosis with repeat angioplasty when the procedure is performed during diagnosis or, as an alternative, when it is performed as a separate elective procedure, we prospectively compared the outcome of 48 consecutive procedures (including 51 lesion...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Alfonso F,Macaya C,Iñiguez A,Zarco P

    更新日期:1990-02-01 00:00:00

  • Patterns of inflammation associated with peripheral arterial disease: the InCHIANTI study.

    abstract:OBJECTIVE:To determine whether peripheral arterial disease is associated with high circulating levels of pro-inflammatory cytokines, independent of confounders. METHODS:Participants were 955 men and women aged 60 years and older representative of the population in 2 Italian communities (107 with peripheral arterial di...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究


    authors: McDermott MM,Guralnik JM,Corsi A,Albay M,Macchi C,Bandinelli S,Ferrucci L

    更新日期:2005-08-01 00:00:00

  • Danish multicenter randomized study on fibrinolytic therapy versus acute coronary angioplasty in acute myocardial infarction: rationale and design of the DANish trial in Acute Myocardial Infarction-2 (DANAMI-2).

    abstract:BACKGROUND:Randomized trials have indicated that primary coronary angioplasty performed in patients admitted directly to highly-experienced angioplasty centers offers certain advantages over intravenous fibrinolytic therapy. However, the large majority of patients with acute myocardial infarction are submitted to hospi...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Andersen HR,Nielsen TT,Vesterlund T,Grande P,Abildgaard U,Thayssen P,Pedersen F,Mortensen LS,DANAMI-2 Investigators.

    更新日期:2003-08-01 00:00:00

  • Genetic diversity of the KCNE1 gene and susceptibility to postoperative atrial fibrillation.

    abstract:BACKGROUND:The human KCNE1 protein forms the β-subunit of the IKs potassium channel and is important in the regulation of the atrial action potential duration. The purpose of this study was to investigate the association between the nonsynonymous 112G>A mutation of the KCNE1 gene and postcardiac surgery atrial fibrilla...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Voudris KV,Apostolakis S,Karyofillis P,Doukas K,Zaravinos A,Androutsopoulos VP,Michalis A,Voudris V,Spandidos DA

    更新日期:2014-02-01 00:00:00

  • Balloon angioplasty of the aorta in Takayasu's arteritis: initial and long-term results.

    abstract::Percutaneous transluminal balloon angioplasty for stenosis of the aorta was performed in 36 patients with Takayasu's arteritis (age range, 8 to 36 years; mean, 19.1 +/- 7.7 years). Balloon dilatation was successful in 34 patients and resulted in a decrease in the mean peak systolic pressure gradient (PSG) from 75.2 +/...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Tyagi S,Kaul UA,Nair M,Sethi KK,Arora R,Khalilullah M

    更新日期:1992-10-01 00:00:00

  • Unsuccessful reperfusion in patients with ST-segment elevation myocardial infarction treated by primary angioplasty.

    abstract:BACKGROUND:Several studies have shown that patency of the epicardial vessel does not guarantee optimal myocardial perfusion in patients undergoing primary angioplasty for ST-segment elevation myocardial infarction (STEMI). The aim of the current study was to identify clinical and angiographic correlates of unsuccessful...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: De Luca G,van 't Hof AW,Ottervanger JP,Hoorntje JC,Gosselink AT,Dambrink JH,Zijlstra F,de Boer MJ,Suryapranata H

    更新日期:2005-09-01 00:00:00

  • Return to the workforce following infective endocarditis-A nationwide cohort study.

    abstract:BACKGROUND:The ability to return to work after infective endocarditis (IE) holds important socioeconomic consequences for both patients and society, yet data on this issue are sparse. We examined return to the workforce and associated factors in IE patients of working age. METHODS:Using Danish nationwide registries, w...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究


    authors: Butt JH,Kragholm K,Dalager-Pedersen M,Rørth R,Kristensen SL,Chaudry MS,Valeur N,Østergaard L,Torp-Pedersen C,Gislason GH,Køber L,Fosbøl EL

    更新日期:2018-01-01 00:00:00

  • Influence of gravity on pulmonary venous flow velocity patterns: analysis of left and right pulmonary venous flow velocities in left and right decubitus positions.

    abstract:BACKGROUND:The pulmonary venous flow signal measured by transesophageal echocardiography is generally recorded from the left upper pulmonary vein in the left lateral decubitus position, whereas that by transthoracic echocardiography is from the right upper pulmonary vein in the left semi-lateral decubitus position. The...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Izumi C,Iga K,Himura Y,Gen H,Konishi T

    更新日期:1999-03-01 00:00:00

  • Doppler echocardiographic studies of diastolic ventricular filling patterns in premature infants.

    abstract::Pulsed Doppler echocardiographic studies of both right and left ventricular diastolic inflow patterns were performed in 10 full-term newborn infants and serially during the first month of life in 21 premature (28 to 35 weeks' gestation) infants with no clinical cardiorespiratory disease. Results of studies performed d...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Johnson GL,Moffett CB,Noonan JA

    更新日期:1988-12-01 00:00:00

  • Patterns of management of atrial fibrillation complicating coronary artery bypass grafting: Results from the PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT-IV) Trial.

    abstract:BACKGROUND:Current practice related to the management of atrial fibrillation (AF) complicating coronary artery bypass grafting (CABG) is uncertain. METHODS:We examined management of post-CABG AF in the PREVENT-IV trial, and we explored patterns of use of postoperative rhythm versus rate control and anticoagulation for...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验


    authors: Al-Khatib SM,Hafley G,Harrington RA,Mack MJ,Ferguson TB,Peterson ED,Califf RM,Kouchoukos NT,Alexander JH

    更新日期:2009-11-01 00:00:00

  • Short- and long-term changes in myocardial function, morphology, edema, and infarct mass after ST-segment elevation myocardial infarction evaluated by serial magnetic resonance imaging.

    abstract:BACKGROUND:Knowledge of the natural course after an ST-elevation myocardial infarction (STEMI) treated according to guidelines is limited because comprehensive serial magnetic resonance imaging (MRI) of systolic left ventricular function, edema, perfusion, and infarct size after STEMI has not been undertaken. The aim o...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Ripa RS,Nilsson JC,Wang Y,Søndergaard L,Jørgensen E,Kastrup J

    更新日期:2007-11-01 00:00:00

  • The triglyceride-high-density lipoprotein axis: an important target of therapy?

    abstract::Coronary heart disease is the single largest cause of morbidity and mortality in the United States. The link between elevated low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) has been clearly established. However, triglycerides (TG) are increasingly believed to be independently assoc...

    journal_title:American heart journal

    pub_type: 杂志文章,评审


    authors: Szapary PO,Rader DJ

    更新日期:2004-08-01 00:00:00

  • Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: a potential approach to identify atherosclerotic disease progression.

    abstract:BACKGROUND:The study rationale was to compare the biomarker profile of metalloproteinases (MMPs) and inflammation markers (IMs) in patients requiring revascularization with that of patients with long-term, clinically quiescent coronary artery disease (CAD). METHODS:Seventy-eight patients with symptomatic CAD (S-CAD) (...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Gurbel PA,Kreutz RP,Bliden KP,DiChiara J,Tantry US

    更新日期:2008-01-01 00:00:00

  • Transdermal clonidine as an adjunct to nifedipine-GITS therapy in patients with mild-to-moderate hypertension.

    abstract::Calcium channel blockers and central alpha-agonists are among the classes of antihypertensive drugs that yield the most favorable overall effects on risk factors for hypertension-related end-organ damage. An open-label prospective trial in 42 patients with a mean baseline blood pressure of 144/102 mm Hg sought to asse...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章


    authors: Houston MC,Hays L

    更新日期:1993-10-01 00:00:00

  • Race-ethnic differences in subclinical left ventricular systolic dysfunction by global longitudinal strain: A community-based cohort study.

    abstract:BACKGROUND:Race-ethnic differences exist in the epidemiology of heart failure, with blacks experiencing higher incidence and worse prognosis. Left ventricular (LV) systolic dysfunction (LVSD) detected by speckle-tracking global longitudinal strain (GLS) is a predictor of cardiovascular events including heart failure. I...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Russo C,Jin Z,Homma S,Rundek T,Elkind MS,Sacco RL,Di Tullio MR

    更新日期:2015-05-01 00:00:00

  • Vitamin K epoxide reductase complex subunit 1 gene polymorphism is associated with atherothrombotic complication after drug-eluting stent implantation: 2-Center prospective cohort study.

    abstract:BACKGROUND:Single nucleotide polymorphisms of vitamin K epoxide reductase complex subunit 1 (VKORC1) was reported to have association with arterial vascular disease. We investigated whether single nucleotide polymorphism of VKORC1 +2255 is associated with clinical outcomes among patients who underwent drug-eluting sten...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究


    authors: Suh JW,Baek SH,Park JS,Kang HJ,Chae IH,Choi DJ,Park HJ,Kim PJ,Seung KB,Kim HS

    更新日期:2009-05-01 00:00:00

  • Long-term outcome after heart transplantation for peripartum cardiomyopathy.

    abstract::To elucidate the long-term outcome and frequency of complications after heart transplantation for peripartum cardiomyopathy (PPCM), we compared the courses of eight consecutive patients undergoing transplantation for PPCM with those of nine female age-matched control subjects undergoing transplantation for idiopathic ...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Rickenbacher PR,Rizeq MN,Hunt SA,Billingham ME,Fowler MB

    更新日期:1994-05-01 00:00:00

  • Age, knowledge, preferences, and risk tolerance for invasive cardiac care.

    abstract:BACKGROUND/OBJECTIVES:The extent to which individual knowledge, preferences, and priorities explain lower use of invasive cardiac care among older vs. younger adults presenting with acute coronary syndrome (ACS) is unknown. We directly surveyed a group of patients to ascertain their preferences and priorities for invas...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Nanna MG,Peterson ED,Wu A,Harding T,Galanos AN,Wruck L,Alexander KP

    更新日期:2020-01-01 00:00:00

  • Prognostic implications of complicated ventricular arrhythmias early after hospital discharge in acute myocardial infarction: a serial ambulatory electrocardiography study.

    abstract::To assess the prevalence and prognostic implications of complicated ventricular ectopic depolarizations (VEDs) after hospital discharge in patients with acute myocardial infarction (AMI), we obtained serial 24-hour Holter recordings in 85 patients during the first 6 weeks after AMI. Recordings were obtained during two...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Olson HG,Lyons KP,Troop P,Butman SM,Piters KM

    更新日期:1984-11-01 00:00:00

  • Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: Results from a randomized pilot study of exercise intervention.

    abstract:BACKGROUND:In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce t...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验


    authors: deFilippi CR,de Lemos JA,Newman AB,Guralnik JM,Christenson RH,Pahor M,Church T,Espeland M,Krithevsky SB,Stafford R,Seliger SL,LIFE Study Group.

    更新日期:2016-09-01 00:00:00

  • Myocardial infarct size reduction by the synergistic effect of hyperbaric oxygen and recombinant tissue plasminogen activator.

    abstract::Fasting mongrel dogs underwent hyperbaric oxygen treatment (HBOT), recombinant tissue plasminogen activator (rt-PA) treatment, and simultaneous HBOT and rt-PA treatment following prior experimental left anterior descending coronary artery occlusion for 2 hours. Thrombosis in and around a copper coil was recorded angio...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Thomas MP,Brown LA,Sponseller DR,Williamson SE,Diaz JA,Guyton DP

    更新日期:1990-10-01 00:00:00

  • Alcohol-induced changes in serum lipoproteins and in their metabolism.

    abstract::The effects of alcohol intake on serum lipids and lipoproteins depend on the dose and mode of alcohol intake, individual susceptibility, genetic variables, and dietary factors. Therefore the changes of lipoprotein pattern are different among moderate and heavy drinkers. Moderate intake of alcohol increases the concent...

    journal_title:American heart journal

    pub_type: 杂志文章,评审


    authors: Taskinen MR,Nikkilä EA,Välimäki M,Sane T,Kuusi T,Kesäniemi A,Ylikahri R

    更新日期:1987-02-01 00:00:00

  • A controlled trial of intramuscular lidocaine in the prevention of premature ventricular contractions associated with acute myocardial infarction.

    abstract::Intramuscular lidocaine administration is known to produce blood concentration levels considered to be therapeutic for prevention of premature ventricular contractions. This double blind study was designed to study the effect of intramuscular lidocaine in the prevention of PVC's in acute myocardial infarction. Forty-s...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章


    authors: Singh JB,Kocot SL

    更新日期:1976-04-01 00:00:00

  • Current antiplatelet therapies: benefits and limitations.

    abstract::Antiplatelet therapy is the current criterion standard for the treatment of patients undergoing percutaneous coronary intervention and patients who have acute coronary syndromes. Clopidogrel in combination with aspirin is the current standard of care for reducing cardiovascular events in these patients. However, patie...

    journal_title:American heart journal

    pub_type: 杂志文章,评审


    authors: Angiolillo DJ,Guzman LA,Bass TA

    更新日期:2008-08-01 00:00:00

  • Effect of low-grade conductive heating on vascular compliance during in vitro balloon angioplasty.

    abstract::Radiofrequency-powered, thermal balloon angioplasty is a new technique that enhances luminal dilatation with less dissection than conventional angioplasty. The purpose of this study was to assess the effect of radiofrequency heating of balloon fluid on the pressure-volume mechanics of in vitro balloon angioplasty and ...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Mitchel JF,Fram DB,Aretz TA,Gillam LD,Woronick C,Waters DD,McKay RG

    更新日期:1994-07-01 00:00:00

  • Validation of an automated electronic algorithm and "dashboard" to identify and characterize decompensated heart failure admissions across a medical center.

    abstract:BACKGROUND:We aim to validate the diagnostic performance of the first fully automatic, electronic heart failure (HF) identification algorithm and evaluate the implementation of an HF Dashboard system with 2 components: real-time identification of decompensated HF admissions and accurate characterization of disease char...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Cox ZL,Lewis CM,Lai P,Lenihan DJ

    更新日期:2017-01-01 00:00:00

  • Population screening for plasma cholesterol: community-based results from Connecticut.

    abstract::Plasma cholesterol levels were measured in 15,892 participants of a cholesterol screening in Hartford, Connecticut. The screenees were typically health conscious as evidenced by the low prevalence of current cigarette smoking (12%). However, more than 25% of the men and 35% of the women over the age of 50 years had ch...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Wynder EL,Harris RE,Haley NJ

    更新日期:1989-03-01 00:00:00

  • The impact of the AMPD1 gene polymorphism on exercise capacity, other prognostic parameters, and survival in patients with stable congestive heart failure: a study in 686 consecutive patients.

    abstract:BACKGROUND:Previous studies have demonstrated that the adenosine monophosphate deaminase 1 (AMPD1) C34T polymorphism may be associated with survival in cardiac populations with a protective effect of the T allele. However, these studies included limited number of patients with few cardiovascular events. METHODS:We pro...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: de Groote P,Lamblin N,Helbecque N,Mouquet F,Hermant X,Amouyel P,Dallongeville J,Bauters C

    更新日期:2006-10-01 00:00:00

  • Effect of direct stenting on clinical outcome in patients treated with percutaneous coronary intervention on saphenous vein graft.

    abstract:BACKGROUND:Percutaneous coronary intervention (PCI) of saphenous vein graft (SVG) is associated with frequent postprocedural enzyme elevation and late cardiac events. New strategies are proposed to minimize distal embolization and to improve the outcome of patients treated with stenting for SVG lesions. The objectives ...

    journal_title:American heart journal

    pub_type: 杂志文章


    authors: Leborgne L,Cheneau E,Pichard A,Ajani A,Pakala R,Yazdi H,Satler L,Kent K,Suddath WO,Pinnow E,Canos D,Waksman R

    更新日期:2003-09-01 00:00:00