Effect of 2-amino-4-phosphonobutyrate on ERG OFF-response after glycinergic and GABAergic blockade.

Abstract:

:Superfusion with 200 microM 2-amino-4-phosphonobutyrate (APB) of dark and chromatically adapted frog eyecups caused marked potentiation of the ERG OFF-response (d-wave). Blockade of the glycinergic synapses by strychnine did not change this effect at all. Blockade of the GABAergic synapses by picrotoxin slightly diminished the effect of APB in chromatically-adapted eyes with isolated cones' activity, and did not change it in dark-adapted eyes. The results indicate that the action of APB on ERG OFF-response does not depend significantly on GABAergic and glycinergic neurotransmission in frog retina.

journal_name

Vision Res

journal_title

Vision research

authors

Popova E,Kupenova P,Vitanova L,Mitova L

doi

10.1016/0042-6989(94)00310-i

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

1945-9

issue

14

eissn

0042-6989

issn

1878-5646

pii

0042-6989(94)00310-I

journal_volume

35

pub_type

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