Abstract：
:Microglia dynamically prune synaptic contacts during development, and digest waste that accumulates in degeneration and aging. In many neurodegenerative diseases, microglial activation and phagocytosis gradually increase over months or years, with poorly defined initial triggering events. Here, we describe rapid retinal microglial activation in response to physiological light levels in a mouse model of photoreceptor degeneration that arises from defective rhodopsin deactivation and prolonged signaling. Activation, migration and proliferation of microglia proceeded along a well-defined time course apparent within 12 h of light onset. Retinal imaging in vivo with optical coherence tomography revealed dramatic increases in light-scattering from photoreceptors prior to the outer nuclear layer thinning classically used as a measure of retinal neurodegeneration. This model is valuable for mechanistic studies of microglial activation in a well-defined and optically accessible neural circuit, and for the development of novel methods for detecting early signs of pending neurodegeneration in vivo.
journal_name
Vision Resjournal_title
Vision researchauthors
Levine ES,Zam A,Zhang P,Pechko A,Wang X,FitzGerald P,Pugh EN Jr,Zawadzki RJ,Burns MEdoi
10.1016/j.visres.2014.07.011subject
Has Abstractpub_date
2014-09-01 00:00:00pages
71-9eissn
0042-6989issn
1878-5646pii
S0042-6989(14)00170-9journal_volume
102pub_type
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