Abstract：
:Serotonergic neurons in the dorsal raphe nucleus (DR) are organized in anatomically distinct subregions that form connections with specific brain structures to modulate diverse behaviors, including anxiety-like behavior. It is unclear if the functional heterogeneity of these neurons is coupled to their developmental heterogeneity, and if abnormal development of specific DR serotonergic subregions can permanently impact anxiety circuits and behavior. The goal of this study was to examine if deficiencies in different components of fibroblast growth factor (Fgf) signaling could preferentially impact the development of specific populations of DR serotonergic neurons to alter anxiety-like behavior in adulthood. Wild-type and heterozygous male mice globally hypomorphic for Fgf8, Fgfr1, or both (Fgfr1/Fgf8) were tested in an anxiety-related behavioral battery. Both Fgf8- and Fgfr1/Fgf8-deficient mice display increased anxiety-like behavior as measured in the elevated plus-maze and the open-field tests. Immunohistochemical staining of a serotonergic marker, tryptophan hydroxylase (Tph), revealed reductions in specific populations of serotonergic neurons in the ventral, interfascicular, and ventrolateral/ventrolateral periaqueductal gray subregions of the DR in all Fgf-deficient mice, suggesting a neuroanatomical basis for increased anxiety-like behavior. Overall, this study suggests Fgf signaling selectively modulates the development of different serotonergic neuron subpopulations. Further, it suggests anxiety-like behavior may stem from developmental disruption of these neurons, and individuals with inactivating mutations in Fgf signaling genes may be predisposed to anxiety disorders.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Brooks LR,Enix CL,Rich SC,Magno JA,Lowry CA,Tsai PSdoi
10.1016/j.bbr.2014.01.053subject
Has Abstractpub_date
2014-05-01 00:00:00pages
74-81eissn
0166-4328issn
1872-7549pii
S0166-4328(14)00067-9journal_volume
264pub_type
杂志文章abstract：:Alzheimer's disease (AD) is an irreversible, progressive brain disorder of the elderly characterized by learning and memory impairment. Stress level glucocorticoids (GCs) and β-amyloid (Aβ) peptides deposition are found to be correlated with dementia progression in patients with AD. However, little is known about the ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.10.038
更新日期：2012-02-01 00:00:00
abstract：:The present study was aimed at evaluating whether the differences between the Roman high- (RHA) and low-avoidance (RLA) rat strains in novelty-induced behavioural inhibition/disinhibition, sensorimotor gating (i.e., prepulse inhibition, PPI) and spatial learning/memory parallel differences in the volume of brain areas...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.12.033
更新日期：2019-04-01 00:00:00
abstract：:Intracranial administration of glutamate to the chicken in the first week of life subsequently retards visual discrimination learning. After this susceptible period in the first week, the brain can more effectively metabolize or extrude a loading dose of glutamate. The potent glutamate and aspartate agonists, kainic a...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(82)90160-7
更新日期：1982-01-01 00:00:00
abstract：:Subregional analyses of the hippocampus suggest CA1-dependent memory processes rely heavily upon interactions between the CA1 subregion and entorhinal cortex. There is evidence that the direct perforant path (pp) projection to CA1 is selectively modulated by dopamine while having little to no effect on the Schaffer co...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.01.002
更新日期：2008-06-03 00:00:00
abstract：:Forced swimming test (FST) or 'behavioural despair' test is a useful screening for antidepressant drugs. The FST predictability has been improved by a number of procedural modifications. Description of the behavioural microstructure in FST may help to delineate innovative protocols. Thus, counts of all behaviours emit...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.09.004
更新日期：2005-03-30 00:00:00
abstract：BACKGROUND:Addiction is a chronic disease characterized by persistent vulnerability to relapse during abstinence. In animal models of addiction, accumulating evidence suggests that exposure to environmental enrichment (EE) during periods of abstinence can have curative effects on addiction and reduce the risks of relap...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.12.027
更新日期：2018-04-02 00:00:00
abstract：:In late-stage embryos of domestic fowl, exposure of the right eye to light entering through the shell induces asymmetry of the thalamofugal visual pathway, together with differences in performance according to whether the right or left eye (RE, LE) is in use (Behav. Brain Res. 38 (1990) 211). Nevertheless, at least so...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.04.016
更新日期：2004-11-05 00:00:00
abstract：:Recent studies suggest a potential role for 5-hydroxytryptamine(6) (5-HT(6)) receptors in the regulation of addictive behavior. In the present study, our aim was to investigate whether the novel highly selective 5-HT(6) receptor antagonist compound (CMP) 42 affected nicotine and ethanol seeking behavior in Wistar rats...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.08.048
更新日期：2013-01-01 00:00:00
abstract：:This study investigated the possible influence of the Subdural Pharmacotherapy Device (SPD) on spatial memory in 3 adult, male bonnet macaques (Macaca radiata). The device was implanted in and above the subdural/subarachnoid space and cranium overlaying the right parietal/frontal cortex: a circuitry involved in spatia...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.03.014
更新日期：2015-06-01 00:00:00
abstract：:The mechanism underlying the relationship between autistic traits and social anxiety still remains unknown. It is therefore necessary to investigate potential psychological and biological mechanisms. A total of 3000 college students were samples for this research during 2017-2018. The assessed variables included demog...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2021.113142
更新日期：2021-01-25 00:00:00
abstract：:Physical exercise could be a protective factor against the development of substance use disorders; however, a number of preclinical studies report reward-enhancing effects of exercise for various drugs of abuse. We examined the effects of chronic wheel-running on brain reward sensitivity, reaction to novelty, reward-f...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112831
更新日期：2020-09-15 00:00:00
abstract：:Catechol-O-methyltransferase, an enzyme involved in regulating brain catecholamine levels, has been implicated in anxiety, pain and/or stress responsivity. Elements of this putative association remain unclarified, notably whether: (a) COMT variation modulates responses to acute and/or chronic stress equally; (b) acute...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.12.014
更新日期：2012-03-17 00:00:00
abstract：:In this brief review, we present the evidence for the regulation of the mesolimbic dopamine system by 5-HT3 and 5-HT4 receptors. A range of studies show good evidence that 5-HT3 receptor antagonists reduce raised mesolimbic dopamine activity by blocking 5-HT3 receptors in terminal parts of the mesolimbic dopamine syst...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(96)00063-0
更新日期：1996-01-01 00:00:00
abstract：:The effects of adrenalectomy and chronic corticosterone treatment on sexual behavior in the ovariectomized female rat were investigated. The serotonergic type 2A (5-HT2A) receptor-mediated behavior 'wet dog shakes' (WDS) was measured concurrently. In Experiment 1, adrenalectomy reduced the frequency of WDS following t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00046-7
更新日期：1999-10-01 00:00:00
abstract：:Drug addiction is a chronic mental disorder characterized by frequent relapses. Contextual cues associated with drug use to play a critical causal role in drug-seeking behavior. The hippocampus has been implicated in encoding drug associative memories. Here we examine whether the dorsal hippocampus mediates context-in...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112978
更新日期：2021-02-01 00:00:00
abstract：:This work was aimed to study if goldfish telencephalon is involved differentially in spatial and cue learning. With this purpose, animals were assigned to two learning conditions, 'spatial constancy' and 'directly cued', and their performance was recorded before and after ablation of the telencephalon. During the pres...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(96)00014-9
更新日期：1996-09-01 00:00:00
abstract：:In order to investigate the relative contribution of dopaminergic projections to the nucleus accumbens and prefrontal cortex in the regulation of spontaneous and drug-induced locomotor activity, separate groups of rats were prepared with 6-OHDA lesions of the ventral tegmental area alone, or additional grafts of dopam...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(84)90031-7
更新日期：1984-07-01 00:00:00
abstract：:Chronic restraint stress (CRS) causes hippocampal neurodegeneration and hippocampus-dependent cognitive deficits. Flupirtine represents neuroprotective effects and we have previously shown that flupirtine can protect against memory impairment induced by acute stress. The present study aimed to investigate whether flup...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.04.004
更新日期：2015-07-15 00:00:00
abstract：:Across species, greater cortical gyrification, or folding of the cortex, has been shown to be associated with higher cognitive abilities and is thought to reflect an evolutionary process aimed at maximizing the number of cerebral computational units while minimizing the energy and communication costs of larger brains....
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.03.018
更新日期：2015-01-01 00:00:00
abstract：:Memory consolidation is the process by which recently acquired information becomes stable and is modulated by different neurotransmitters depending on the structure involved and the nature of the memory. Here we evaluate the participation of both D1 and D5 dopamine receptors in the CA1 region of the hippocampus in the...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.06.027
更新日期：2014-09-01 00:00:00
abstract：:Physiological effects of different types, of continuous and interval aerobic training, have been largely described and studied in the adult man. It was previously indicated that interval training plays an important role in maximizing both peripheral muscle and central cardiorespiratory adaptations, permitting signific...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.05.058
更新日期：2017-08-14 00:00:00
abstract：:The role of forebrain catecholamine systems in spatial learning was assessed using a recently described place navigation task. Rats were required to learn the spatial location of a platform hidden 1 cm below the surface in order to escape from a large pool filled with opaque water. Circumscribed destruction of dopamin...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(83)90015-3
更新日期：1983-07-01 00:00:00
abstract：:Motor performance declines with increasing age and it has been proposed that elder people might compensate for these deficits with increased cerebral activation. However, it is not known, whether increased activation - especially in motor areas of the contralateral and the ipsilateral cerebral hemisphere - might effec...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.04.040
更新日期：2011-10-01 00:00:00
abstract：:We have previously demonstrated that kindling of the nucleus accumbens (NAc) induced psychosis relevant behaviors only after one, but not after five, stage-5 seizures, suggesting that five stage-5 NAc-evoked seizures antagonized psychosis relevant behaviors in rats. We hypothesized that brain opioid receptors are resp...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.09.007
更新日期：2019-01-01 00:00:00
abstract：:Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder with a characteristic triad of cognitive, affective and motor symptoms. Transgenic HD mice show excellent construct and face validity for many of these symptoms, however the decline in some facets of every day activity in humans is difficul...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.04.003
更新日期：2015-01-01 00:00:00
abstract：:Latent inhibition (LI) is a behavioural procedure used to evaluate the potential propsychotic and antipsychotic properties of psychoactive drugs. In the present study, a conditioned taste aversion (CTA) procedure was used to investigate the effects of the nitric oxide (NO) synthase inhibitor, N(G)-nitro-L-arginine met...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.01.008
更新日期：2005-06-03 00:00:00
abstract：:Neuronal activity was recorded in the hippocampal formation, the parahippocampal gyrus and medial inferotemporal cortex of monkeys performing memory tasks. In a modified delayed matching to sample task in which 2 sequentially presented stimuli were compared on each trial, a match condition required a right panel press...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90038-g
更新日期：1990-10-30 00:00:00
abstract：:There is evidence that pain can impact cognitive function in people. The present study evaluated whether Pavlovian fear conditioning in rats would be reduced if conditioning were followed by persistent inflammatory pain induced by a subcutaneous injection of dilute formalin or complete Freund's adjuvant (CFA) on the d...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.08.048
更新日期：2012-01-15 00:00:00
abstract：:Many studies have demonstrated that stressors can modify the physiological action of drugs, mainly morphine. The present study investigated the effects of a mild stressor on chloral hydrate (Chl)-induced sedation in mice. For 4 consecutive days, NaCl and Chl-treated mice (300 mg kg(-1)) were stressed (S) either by a 5...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00228-x
更新日期：2000-09-01 00:00:00
abstract：:Rats were randomly assigned to enriched (EE) or standard environments (SE) at 21 or 73 days of age, for 17 days. Half of the rats of each rearing condition were trained in a radial maze (RM). At 38 days (pre-pubertal) or 90 days (young), rats were sacrificed and brain cytosolic and mitochondrial nitric oxide synthase ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.06.024
更新日期：2007-12-03 00:00:00
