[Effects of neomycin on intestinal digestion, absorption and fermentation of carbohydrates in patients with liver cirrhosis: evidence for an alternative therapeutic mechanism in hepatic encephalopathy].

Abstract:

BACKGROUND:Despite non absorbable antibiotics and neomycin may have antagonistic effects on intestinal bacterial environment, both have synergistic effects in the treatment of hepatic encephalopathy. This could be due to their action on different enteric flora or a neomycin induced carbohydrate malabsorption. AIM:To investigate the effects of neomycin on intestinal digestion, absorption and fermentation of carbohydrates in patients with liver cirrhosis. PATIENTS AND METHODS:Thirty eight Child B or C cirrhotic patients separated in three groups; subjects within each group were randomized to receive neomycin (2/g/day for 10 days, n = 8) or placebo (n = 4). Absorption of lactose and d-xylose and fermentation of d-xylose, lactose and lactulose (measured using hydrogen breath tests) were studied before and after the treatment period. RESULTS:Neomycin did not change lactose fermentation but reduced plasma glucose rise after lactose ingestion (38.8 +/- mg/dl to 22 +/- 6 mg/dl p < 0.05). Plasma d-xylose levels at 30 min and its 5 h urinary excretion were reduced by neomycin from 19 +/- 3 to 9 +/- 2 mg/dl and from 4.9 +/- 0, 8 to 2.6 +/- 0.3 g/5h respectively (p < 0.05). Fermentation of d-xylose, lactose and lactulose was not reduced by neomycin. No significant changes were observed after placebo treatment. CONCLUSIONS:Neomycin therapy is associated with a reduction of intestinal digestion and absorption of carbohydrates, preserving bacterial fermentation capacity, probably increasing the non absorbable carbohydrate load reaching the colon.

journal_name

Rev Med Chil

journal_title

Revista medica de Chile

authors

Chesta J,Antezana C

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

365-71

issue

4

eissn

0034-9887

issn

0717-6163

journal_volume

122

pub_type

临床试验,杂志文章,随机对照试验
  • [Treatment of Hodgkin's disease. National Protocol of Antineoplastic Drugs: preliminary report].

    abstract::We report preliminary results of treatment of Hodgkin disease according to the National Protocol on Antineoplastic Drugs. 37 males and 22 females with a median age of 34 years (range 16 to 76) were treated. Patients with stages I or II received radiotherapy alone or chemotherapy (C-MOPP) followed by radiotherapy. Pati...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Gutiérrez J,Osorio G,García H,Vacarezza R,Cao C

    更新日期:1991-01-01 00:00:00

  • [Late centronuclear myopathy: autosomal dominant form].

    abstract::We report a family with three generations affected by an autosomal dominant centronuclear palsy. This gene is characterized by ptosis that begins in childhood and a slowly progressive weakness that starts in the second decade of life, involving face, neck and limbs. In this stage, muscle pan associated to exercise or ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Cartier L,Hernández JE

    更新日期:1996-02-01 00:00:00

  • [Chest pain unit: first experience in Chile].

    abstract:BACKGROUND:In large series, nearly 60% of admissions for suspected acute coronary syndrome (ACS) had a non-coronary etiology of the pain. However, short term mortality of non recognized ACS patients, mistakenly discharged from the emergency room is at least twice greater than the expected if they would had been admitte...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872007000700003

    authors: Castro P,Corbalán R,Isa R,Gabrielli L,Pérez O,Chamorro G,Garayar B,Baeza R,Vergara I,Godoy I,Acevedo M,Fajuri A,Fernández M,Mardones JM,Bittner A,Rodríguez JA

    更新日期:2007-07-01 00:00:00

  • [Immunophenotype. Clinical and laboratory features of acute lymphoblastic leukemia in Chile. Study of 500 children and 131 adults].

    abstract::We describe the clinical features and immunophenotype of 500 children and 131 adults with acute lymphoblastic leukemia (ALL), diagnosed between 1984 and 1993. Cases were classified, according to immunophenotype in B-cell ALL with three subtypes (pro-B or null, common and B) and T-cell ALL. Among children, common ALL a...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Cabrera ME,Labra S,Ugarte S,Matutes E,Greaves MF

    更新日期:1996-03-01 00:00:00

  • [Association between food addiction and nutritional status in Chilean college students].

    abstract:BACKGROUND:High calorie foods, especially high in sugar and sodium may have an addictive potential. Experimental rats are able to develop symptoms and neurochemical changes, comparable to those observed in drug abuse, when they are exposed intermittently to sucrose. AIM:To evaluate the association between nutritional ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872015000500006

    authors: Obregón A,Fuentes J,Pettinelli P

    更新日期:2015-05-01 00:00:00

  • [Long-term results of mitral valve repair for ischemic mitral insufficiency].

    abstract:BACKGROUND:The preferred treatment for ischemic mitral insufficiency is mitral valve repair with a prosthetic ring, because it does not deteriorate left ventricular function, allowing better immediate and long-term results. AIM:To assess long-term results of mitral annuloplasty with a prosthetic ring for ischemic mitr...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872011001200003

    authors: Zalaquett S R,Flores A E,Cartajena de la M F,Bächler S P,Córdova A S,Becker R P,Morán V S,Irarrázabal Ll M,Muñoz C C,González F R

    更新日期:2011-12-01 00:00:00

  • [Subcortical dementia in HTLV-I tropical spastic paraparesis. Study of 43 cases].

    abstract:BACKGROUND:Central nervous system damage associated to HTLV-I does not limit itself to the spinal cord, but also involves subcortical structures, producing cognitive impairment and behavioral changes which eventually could conform a new form of subcortical dementia. AIM:To study cognitive changes in patients with HTLV...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Cartier L,Gormaz A

    更新日期:1999-04-01 00:00:00

  • [Small-for-size syndrome. Report of one case].

    abstract::Although the use of cadaveric split or living donor liver transplantation is a valid option for liver transplants, they have several complications, being the "small-for-size syndrome" one of the most frequent. This entity is mainly due to the incapacity that the graft has to meet the blood drainage demands. We report ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000700009

    authors: Yarur A,Castro L,Segovia R,Roblero JP,Uribe M,Ferrario M,Buckel E

    更新日期:2009-07-01 00:00:00

  • [Screening and barriers for treatment of postpartum depression in Chilean public primary health care centers].

    abstract:BACKGROUND:Postpartum depression (PPD) is a public health issue, and appropriate screening may lead to clinical gains. AIM:To describe the screening for PPD, its relationship with the use of health care services, and treatment access barriers in Chilean public primary health care (PHC) centers. MATERIAL AND METHODS:P...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,多中心研究

    doi:10.4067/s0034-98872018000901001

    authors: Rojas G,Guajardo V,Martínez P,Fritsch R

    更新日期:2018-09-01 00:00:00

  • [Chronic inflammatory demyelinating polyneuropathy. Report of six cases].

    abstract::Chronic inflammatory demyelinating polyneuropathy is a heterogeneous disease characterized by symmetrical motor and sensitive alterations, absence of tendon reflexes and increased cerebrospinal fluid protein levels. We report 6 patients with the disease, (three males) aged 41 to 70 years old. Four had the classical pr...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Araya P,Fruns M,Silva C,Pedraza L

    更新日期:1996-11-01 00:00:00

  • [From insulin pump and continuous glucose monitoring to the artificial pancreas].

    abstract::Technology for diabetes care has undergone major development during recent decades. These technological advances include continuous subcutaneous insulin infusion (CSII), also known as insulin pumps, and real-time continuous glucose monitoring system (RT-CGMS). The integration of CSII and RT-CGMS into a single device h...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872017000500011

    authors: Apablaza P,Soto N,Codner E

    更新日期:2017-05-01 00:00:00

  • [Cerebral vein thrombosis secondary to closed head injury. Report of one case].

    abstract::Intracranial sinus thrombosis (1ST) after closed head injury is an uncommon but potentially serious complication. It has no correlation with the severity of the injury. The symptoms and clinical course are highly variable. The most frequent but least specific symptom is severe headache. Cerebral lesions and neurologic...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872013001200016

    authors: Suárez H F,Mellado T P,Godoy F J

    更新日期:2013-12-01 00:00:00

  • [Estimation of the number of institutionalized elderly in Chile].

    abstract:BACKGROUND:Elderly people (>60 years) in Chile represented 11.4% (n=1,717,478) of the total population in 2002. The group with disabilities or mental problems is increasing and there is no reliable information about the number of institutionalized elderly subjects. AIM:To estimate the number of elderly people living i...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872004000700007

    authors: Marín PP,Guzmán JM,Araya A

    更新日期:2004-07-01 00:00:00

  • [Early test of thallium dipyridamole after myocardial infarction: prognostic value and correlation with coronarography].

    abstract::Fifty three patients were studied with dipyridamole thallium myocardial scintigraphy, 4 to 6 days after a first episode of myocardial infarction. Localization of infarction was anterior in 25 and inferior in 28. Infarction was confirmed by myocardial scintigraphy in 87% of cases. A non q wave myocardial infarction was...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Kunstmann S,Corbalán R,Olea E,Orellana P,Marchant E,Puschel K,Galleguillos CG

    更新日期:1991-08-01 00:00:00

  • [Efficacy and associated costs of an outpatient intervention in women with severe depression and early trauma].

    abstract:BACKGROUND:A high proportion of women consulting for depression have a history of childhood abuse and trauma. AIM:To compare the efficacy and costs associated with a treatment that enquires directly into childhood trauma and understands present interpersonal difficulties as a compulsion to repeat the traumatic past, v...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,随机对照试验

    doi:/S0034-98872010000400006

    authors: Vitriol G V,Cancino A A,Florenzano U R,Ballesteros T S,Schwartz P D

    更新日期:2010-04-01 00:00:00

  • [Application of a diagnostic score for appendicitis by health-related non-physician professionals].

    abstract:BACKGROUND:Diagnostic scores have been developed as simple, user-friendly, cost-effective instruments to improve the early diagnosis of acute appendicitis. AIM:To assess the yield of a diagnostic score for acute appendicitis, measured by trained health-related non-physician professional. PATIENTS AND METHODS:A prospe...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872006000100005

    authors: Beltrán MA,Villar M R,Cruces KS

    更新日期:2006-01-01 00:00:00

  • [The relevance of environmental health and the scope of pediatric environmental health specialty units].

    abstract::In the last decades there has been an important decrease in infant mobidity and mortality, but these achievements are not equally distributed across the whole population. Children are one of the most susceptible groups due to their unique vulnerabilities to environmental factors. Unhealthy environments, indoor polluti...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:/S0034-98872009000100016

    authors: París M E,Bettini M,Molina H,Mieres JJ,Bravo V,Ríos JC

    更新日期:2009-01-01 00:00:00

  • [Prevalence of islet cell antibodies among 1021 relatives of type 1 diabetics].

    abstract:BACKGROUND:An immunological damage of beta cells in the islets of Langerhans, plays a role in the pathogenesis of type 1 diabetes. Recently, the identification of individuals in pre clinical phase and with high risk of developing type 1 diabetes, has become possible by means of the detection of immune markers such as i...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Maiz A,Manrique M,Hodgson MI,Díaz de Valdés M,Acosta AM,Andrade L,Olmos P

    更新日期:1999-05-01 00:00:00

  • [Soft tissue sarcoma. Combined treatment of drug therapy, radiotherapy and conservative surgery].

    abstract::The preliminary results of a prospective and cooperative protocol for the treatment of soft tissue sarcomas of trunk and extremities, stages IB-IIIB are presented. Thirty one patients (17 males, 22 with a tumor larger than 5 cm) aged 16 to 68 years, were treated with one dose of epirubicin 70 mg/m2 i.v. and radiothera...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: San Martín S,Pérez R,Sepúlveda M,Rodríguez M,Durán B,Trujillo C,Arraztoa J

    更新日期:1993-02-01 00:00:00

  • [Metabolic control of non insulin dependent diabetes mellitus in surgery].

    abstract::We followed 50 type II diabetic patients undergoing various types of surgical procedures. Control of blood sugar was evaluated as percent of tests within an acceptable limit defined as 160 mg/dl in the preoperative period, 80-240 mg/dl in the early postoperative period and 80-120 mg/dl thereafter. Adequate control was...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Morales H,Maiz A,Arteaga A

    更新日期:1989-07-01 00:00:00

  • [Trends in current medicine].

    abstract::Predicting the future of medicine is daring. One can speculate about some of its future traits at the most. The spectacular progress in biological sciences has nurtured the hope that medicine will be able to dominate all ailments, improve the quality of life and longevity. Physicians are uncomfortable with the weak kn...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Goic A

    更新日期:1999-09-01 00:00:00

  • [Inactivation of tumor suppressor genes in uterine cervix carcinogenesis].

    abstract::The importance of inactivation of tumor suppressor genes in the development/progression of carcinomas of the uterine cervix is reviewed. It is well known that HPV-related oncogenes are strongly linked to cervical cancer. However, fewer studies have explored the occurrence of inactivation of tumor suppressor genes in t...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:

    authors: Chuaqui R,Cuello M,Emmert-Buck M

    更新日期:1999-12-01 00:00:00

  • [Effectiveness of a dietary and physical activity intervention to prevent obesity in school age children].

    abstract:BACKGROUND:With the aim of contributing to he Healthy Goal 2010 of reducing significantly the prevalence of childhood obesity we developed and implemented during 2003 and 2004, a school-based obesity prevention intervention which included nutrition education and the promotion of physical activity. AIM:To report the re...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,多中心研究

    doi:/S0034-98872008000100003

    authors: Kain J,Uauy R,Leyton B,Cerda R,Olivares S,Vio F

    更新日期:2008-01-01 00:00:00

  • [Ehlers-Danlos syndrome, with special emphasis in the joint hypermobility syndrome].

    abstract::There is an urgent need to increase the awareness on the Joint Hyper mobility Syndrome QHS). This is a congenital and prevalent emergent condition that is frequently undiagnosed and that causes significant health problems. Besides recurrent muscular-skeletal problems and signs and symptoms derived from tissue fragilit...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:/S0034-98872009001100013

    authors: Bravo JF

    更新日期:2009-11-01 00:00:00

  • [Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: advances in pathogenesis and treatment].

    abstract::ANCA (anti-neutrophil cytoplasmic antibodies) associated vasculitis or AAV are a group of diseases with predominant inflammation of small vessels and the presence of detectable ANCA in serum. Due to these common features, it is considered that AAV share pathogenic mechanisms. Consequently, a similar therapeutic approa...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872013000600011

    authors: Silva F,Cisternas M

    更新日期:2013-06-01 00:00:00

  • [Association of Good syndrome with pure red cell aplasia: report of one case].

    abstract::The association between Good's syndrome (hypogammaglobulinemia and thymoma) with pure red aplasia is very uncommon. We report a 70-year-old male, who had a thymoma excised nine years before. Afterwards, he suffered frequent respiratory infections, which were attributed to a humoral immunodeficiency. Nine years later, ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章,评审

    doi:10.4067/S0034-98872012000800013

    authors: Peña C,Intriago M,Muñoz P,Gray AM,Cabrera ME

    更新日期:2012-08-01 00:00:00

  • [Medical coverage of the disease that causes death and place of death in the sixth region of Chile from 1990 to 2003].

    abstract:BACKGROUND:The place of death has changed and coverage of medical attention at death varies according to the development level of countries. AIM:To assess the evolution of coverage of medical attention of the last disease and place of death as indicators of health care quality and development level, in the sixth regio...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/s0034-98872007000800010

    authors: Leiva H H,León K F

    更新日期:2007-08-01 00:00:00

  • [Value of thallium-201 in the non-invasive evaluation of coronary cardiopathy].

    abstract::Normal myocardial cells actively uptake the radioisotope Thallium-201 and its myocardial distribution is a reflection of the existent regional coronary artery blood flow at the moment of the examination. Thallium-201 reaches quickly a high intracellular concentration and then leaves myocardial cells in a mean time of ...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Dighero H,Canessa J

    更新日期:1992-10-01 00:00:00

  • [Day care attendance: impact on acute lower respiratory disease in children under 2 years old].

    abstract:AIM:To measure the impact of day care attendance on lower respiratory tract infections in children under two years old in two urban settings with different degrees of air pollution. SUBJECTS AND METHODS:A 26 week follow up, during fall and winter of 1991 and 1992, was performed to 98 children (48 attending day care an...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:

    authors: Vargas Catalán NA,Díaz Amor P,Zuleta Quiroz A,López Bravo IM,Venegas Silva V

    更新日期:1994-07-01 00:00:00

  • [Fluoride concentration in bottled waters sold in Chile].

    abstract:BACKGROUND:Bottled water consumption has currently increased and their fluoride (F) concentration may not be ideal in terms of caries benefit or risk of fluorosis. While low concentrations would have little anticaries effect, high F concentration would increase the risk of dental fluorosis. AIM:To measure F concentrat...

    journal_title:Revista medica de Chile

    pub_type: 杂志文章

    doi:10.4067/S0034-98872014000500011

    authors: Fernández CE,Giacaman RA,Cury JA

    更新日期:2014-05-01 00:00:00