Risk of stroke with mitral valve prolapse in population-based cohort study.

Abstract:

BACKGROUND AND PURPOSE:The purpose of this study was to clarify whether mitral valve prolapse increases the subsequent risk of stroke. METHODS:A historical cohort study was conducted on 1079 residents of Olmsted County, Minnesota, who had an initial echocardiographic diagnosis of mitral valve prolapse between 1975 and 1989 without prior stroke or transient ischemic attack and who were followed up for first stroke occurrence. RESULTS:There was an overall twofold increase in the incidence of stroke among individuals with mitral valve prolapse relative to the reference population (standardized morbidity ratio, 2.1; 95% confidence interval, 1.3 to 3.2). Sex, duration of follow-up from the diagnosis of mitral valve prolapse, or calendar year of initial diagnosis did not modify the association. Within the cohort of patients who were at least 35 years old at diagnosis of mitral valve prolapse, a time-dependent proportional-hazards multivariate model and a person-years analysis revealed that age, ischemic heart disease, congestive heart failure, and diabetes mellitus were important determinants for stroke when person-years of observation after mitral valve replacement were excluded. Among seven persons with mitral valve replacement, three strokes occurred in 24 person-years of follow-up. For those with an auscultatory diagnosis of mitral valve prolapse only as the indication for echocardiography (44%), the risk of stroke relative to the population was 1.0 (95% confidence interval, 0.2 to 2.9); for those with another cardiac diagnosis, the standardized morbidity ratio was 2.5 (95% confidence interval, 1.5 to 4.0). CONCLUSIONS:Individuals with uncomplicated mitral valve prolapse did not have an increased risk of stroke, although a small increase in the risk may not have been detected.

journal_name

Stroke

journal_title

Stroke

authors

Orencia AJ,Petty GW,Khandheria BK,Annegers JF,Ballard DJ,Sicks JD,O'Fallon WM,Whisnant JP

doi

10.1161/01.str.26.1.7

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

7-13

issue

1

eissn

0039-2499

issn

1524-4628

journal_volume

26

pub_type

杂志文章

相关文献

STROKE文献大全
  • Aspirin use and incident stroke in the cardiovascular health study. CHS Collaborative Research Group.

    abstract:BACKGROUND AND PURPOSE:Randomized clinical trials testing aspirin in relatively low-risk, middle-aged people have consistently shown small increases in stroke associated with aspirin use. We analyzed the relationship between the regular use of aspirin and incident ischemic and hemorrhagic stroke among people aged 65 ye...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.str.29.5.887

    authors: Kronmal RA,Hart RG,Manolio TA,Talbert RL,Beauchamp NJ,Newman A

    更新日期:1998-05-01 00:00:00

  • The cost of pediatric stroke care and rehabilitation.

    abstract:BACKGROUND AND PURPOSE:There is little data regarding the cost of pediatric stroke care or the elements that contribute to these costs. We examined costs for poststroke care during the first year after diagnosis and compared these costs with the volume of the cerebral infarct and the level of neurological and functiona...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.497420

    authors: Lo W,Zamel K,Ponnappa K,Allen A,Chisolm D,Tang M,Kerlin B,Yeates KO

    更新日期:2008-01-01 00:00:00

  • Ankle-Brachial Index and Recurrent Stroke Risk: Meta-Analysis.

    abstract:BACKGROUND AND PURPOSE:The ankle-brachial index (ABI) is a fast, cheap, noninvasive indicator of atherosclerotic burden that may also be a predictor of stroke recurrence. In this systematic review and meta-analysis, we sought to explore ABI's merit as a marker for stroke recurrence and vascular risk by synthesizing the...

    journal_title:Stroke

    pub_type: 杂志文章,meta分析,评审

    doi:10.1161/STROKEAHA.115.011321

    authors: Hong JB,Leonards CO,Endres M,Siegerink B,Liman TG

    更新日期:2016-02-01 00:00:00

  • Stroke rehabilitation outcome. A potential use of predictive variables to establish levels of care.

    abstract:BACKGROUND AND PURPOSE:The most powerful predictors of functional recovery and eventual home discharge among stroke survivors are the initial severity of the stroke and the patient's age. We analyzed a large population of stroke rehabilitation admissions by stratifying subgroups with coherent outcomes in an attempt to ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.1.128

    authors: Alexander MP

    更新日期:1994-01-01 00:00:00

  • Influence of anesthetics on metabolic, functional and pathological responses to regional cerebral ischemia.

    abstract::Regional cerebral ischemia was produced by common carotid artery occlusion in gerbils and by middle cerebral artery occlusion in dogs, cats, and squirrel monkeys. Anesthesia was induced with either pentobarbital or halothane and maintained for two to three hours after vessel occlusion. In acute studies, the effect of ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.6.4.405

    authors: Michenfelder JD,Milde JH

    更新日期:1975-07-01 00:00:00

  • Sulcal effacement with preserved gray-white junction: a sign of reversible ischemia.

    abstract:BACKGROUND AND PURPOSE:Sulcal effacement with preserved underlying gray-white matter junction (isolated sulcal effacement [ISE]) in acute ischemic stroke may not represent irreversible parenchymal injury. We aimed to evaluate the frequency and significance of ISE in patients with large vessel occlusion acute ischemic s...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.115.009304

    authors: Haussen DC,Lima A,Frankel M,Anderson A,Belagaje S,Nahab F,Rangaraju S,Nogueira RG

    更新日期:2015-06-01 00:00:00

  • Role of the nondominant hemisphere and undamaged area during word repetition in poststroke aphasics. A PET activation study.

    abstract:BACKGROUND AND PURPOSE:Although the resting regional cerebral blood flow (rCBF) in aphasic patients has been thoroughly investigated with positron emission tomography (PET) and single-photon emission CT, and PET studies in normal subjects have elucidated the functional localization of language processing, little is kno...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.27.5.897

    authors: Ohyama M,Senda M,Kitamura S,Ishii K,Mishina M,Terashi A

    更新日期:1996-05-01 00:00:00

  • Acute stroke teams: results of a national survey. National Acute Stroke Team Group.

    abstract:BACKGROUND AND PURPOSE:The sensitivity of the brain to brief periods of profound ischemia or prolonged periods of modest ischemia mandates an aggressive approach to acute stroke care. Past studies have shown that many stroke patients do not receive acute care in an urgent and timely fashion. The formation of acute stro...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.11.2318

    authors: Alberts MJ,Chaturvedi S,Graham G,Hughes RL,Jamieson DG,Krakowski F,Raps E,Scott P

    更新日期:1998-11-01 00:00:00

  • Synergistic Interaction Between Zinc and Reactive Oxygen Species Amplifies Ischemic Brain Injury in Rats.

    abstract::Background and Purpose- Although intracellular zinc accumulation has been shown to contribute to neuronal death after cerebral ischemia, the mechanism by which zinc keeps on accumulating to cause severe brain damage remains unclear. Herein the dynamic cause-effect relationships between zinc accumulation and reactive o...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.118.021179

    authors: Zhao Y,Yan F,Yin J,Pan R,Shi W,Qi Z,Fang Y,Huang Y,Li S,Luo Y,Ji X,Liu KJ

    更新日期:2018-09-01 00:00:00

  • New-onset constipation at acute stage after first stroke: incidence, risk factors, and impact on the stroke outcome.

    abstract:BACKGROUND AND PURPOSE:The prevalence of constipation after stroke varies from 30% to 60%. The incidence of new-onset constipation during the early stage of stroke remains uncertain. The present study was designed to investigate the prevalence of new-onset constipation, its risk factors, and its impact on stroke outcom...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.108.534776

    authors: Su Y,Zhang X,Zeng J,Pei Z,Cheung RT,Zhou QP,Ling L,Yu J,Tan J,Zhang Z

    更新日期:2009-04-01 00:00:00

  • Subarachnoid haemorrhage in the rat: effect on the development of cerebral vasospasm of lesions in the central serotoninergic and dopaminergic systems.

    abstract::In the rat an intracisternal injection of blood induces an angiographically demonstrable biphasic cerebral arterial vasospasm. Chemical destruction of the central serotoninergic and dopaminergic pathways prior to the cisternal blood injection does not affect the spasm pattern after the subarachnoid haemorrhage. It is ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.1.86

    authors: Svendgaard NA,Brismar J,Delgado TJ,Rosengren E,Stenevi U

    更新日期:1986-01-01 00:00:00

  • Positive scans in angiographically proved cases of recanalized cerebral infarction.

    abstract::In 20 patients with acute major cerebral arterial occlusion, follow-up angiograms were obtained to inspect the occluded artery. These angiograms were compared with brain scans in the fourth week after the stroke. The angiograms revealed that frequent recanalization of the occluded arteries occurred within a week after...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.6.2.132

    authors: Irino T,Taneda M,Minami T

    更新日期:1975-03-01 00:00:00

  • Carotid artery anatomy and geometry as risk factors for carotid atherosclerotic disease.

    abstract:BACKGROUND AND PURPOSE:Traditional vascular risk factors do not completely explain the asymmetry, racial, and sex differences in carotid artery disease. Carotid anatomy and geometry may play a role in the pathogenesis of internal carotid artery (ICA) stenosis, but their effects are unknown. We hypothesized that carotid...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/STROKEAHA.111.645499

    authors: Phan TG,Beare RJ,Jolley D,Das G,Ren M,Wong K,Chong W,Sinnott MD,Hilton JE,Srikanth V

    更新日期:2012-06-01 00:00:00

  • Cerebral oxygen metabolism and neuronal integrity in patients with impaired vasoreactivity attributable to occlusive carotid artery disease.

    abstract:BACKGROUND AND PURPOSE:It is still unclear that impaired cerebrovascular reactivity (CVR) to acetazolamide is comparable to elevated oxygen extraction fraction (OEF) on positron emission tomography (PET) in patients with occlusive carotid diseases. Therefore, in this study, the authors aimed to clarify whether OEF is e...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000198878.66000.4e

    authors: Kuroda S,Shiga T,Houkin K,Ishikawa T,Katoh C,Tamaki N,Iwasaki Y

    更新日期:2006-02-01 00:00:00

  • Left ventricular mass indexed to height and prevalent MRI cerebrovascular disease in an African American cohort: the Atherosclerotic Risk in Communities study.

    abstract:BACKGROUND AND PURPOSE:Previous studies have demonstrated that echocardiographic left ventricular mass (LVM) is an independent risk factor for stroke in whites. Despite the greater burden of stroke, the echocardiographic predictors of stroke in African Americans remain poorly understood. METHODS:This investigation is ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000154893.68957.55

    authors: Fox ER,Taylor HA Jr,Benjamin EJ,Ding J,Liebson PR,Arnett D,Quin EM,Skelton TN

    更新日期:2005-03-01 00:00:00

  • Postischemic application of lipid peroxidation inhibitor U-101033E reduces neuronal damage after global cerebral ischemia in rats.

    abstract:BACKGROUND AND PURPOSE:The lipid peroxidation inhibitor U-101033E was examined for effects on cerebral blood flow (CBF), cortical tissue hemoglobin oxygen saturation (HbSo2), and neuronal damage. METHODS:Fifteen minutes of global cerebral ischemia was induced by two-vessel occlusion and hypobaric hypotension. Wistar r...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.29.6.1240

    authors: Soehle M,Heimann A,Kempski O

    更新日期:1998-06-01 00:00:00

  • Intravoxel Incoherent Motion Imaging in Small Vessel Disease: Microstructural Integrity and Microvascular Perfusion Related to Cognition.

    abstract:BACKGROUND AND PURPOSE:Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microst...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.015084

    authors: Zhang CE,Wong SM,Uiterwijk R,Staals J,Backes WH,Hoff EI,Schreuder T,Jeukens CR,Jansen JF,van Oostenbrugge RJ

    更新日期:2017-03-01 00:00:00

  • Endogenous dopamine amplifies ischemic long-term potentiation via D1 receptors.

    abstract:BACKGROUND AND PURPOSE:Several observations indicate that, during energy deprivation, endogenous dopamine may become neurotoxic. Accordingly, the nucleus striatum is a preferential site of silent infarcts in humans, and experimental ischemia caused by homolateral carotid occlusion selectively damages this dopamine-enri...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.0000038093.42512.0f

    authors: Saulle E,Centonze D,Martín AB,Moratalla R,Bernardi G,Calabresi P

    更新日期:2002-12-01 00:00:00

  • Delay of stroke onset by milk proteins in stroke-prone spontaneously hypertensive rats.

    abstract:BACKGROUND AND PURPOSE:There is an inverse association between dairy food consumption and the incidence of stroke in observational studies. However, it is unknown whether the relationship is causal or, if so, what components in milk are responsible for reducing the incidence of stroke. METHODS:Stroke-prone spontaneous...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.618496

    authors: Chiba T,Itoh T,Tabuchi M,Ooshima K,Satou T,Ezaki O

    更新日期:2012-02-01 00:00:00

  • Stroke in Commercial Flights.

    abstract:BACKGROUND AND PURPOSE:Stroke on board aircraft has been reported in retrospective case series, mainly focusing on economy class stroke syndrome. Data on the actual incidence, pathogenesis, and prognosis of stroke in commercial flights are lacking. METHODS:A prospective registry was designed to include all consecutive...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.012637

    authors: Álvarez-Velasco R,Masjuan J,DeFelipe A,Corral I,Estévez-Fraga C,Crespo L,Alonso-Cánovas A

    更新日期:2016-04-01 00:00:00

  • Abnormal responses of the human cerebral microcirculation to papaverin during aneurysm surgery.

    abstract:BACKGROUND AND PURPOSE:The role of the cerebral microcirculation in delayed ischemia after subarachnoid hemorrhage remains obscure. To test the hypothesis that cerebral arterioles have a reduced capacity to dilate after subarachnoid hemorrhage, we studied the microvascular responses to papaverine (PPV) in patients unde...

    journal_title:Stroke

    pub_type: 信件

    doi:10.1161/STROKEAHA.108.522375

    authors: Pennings FA,Albrecht KW,Muizelaar JP,Schuurman PR,Bouma GJ

    更新日期:2009-01-01 00:00:00

  • Effects of thrombin inhibitor on thrombin-related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model.

    abstract:BACKGROUND AND PURPOSE:Thrombin is activated in the cerebrospinal fluid (CSF) after a subarachnoid hemorrhage (SAH). However, the relationship between thrombin and cerebral vasospasm has not yet been fully established. The aim of this study was to investigate the possibility of thrombin as a causative factor for cerebr...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000070424.38138.30

    authors: Tsurutani H,Ohkuma H,Suzuki S

    更新日期:2003-06-01 00:00:00

  • Preexisting Heart Disease Underlies Newly Diagnosed Atrial Fibrillation After Acute Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Whether newly diagnosed atrial fibrillation (nAF) after stroke reflects underlying heart disease and represents an increased risk of cardioembolic stroke, or whether it is triggered by neurogenic mechanisms remains uncertain. We investigated, whether cardiovascular risk factors and echocardiograp...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.011465

    authors: Rizos T,Horstmann S,Dittgen F,Täger T,Jenetzky E,Heuschmann P,Veltkamp R

    更新日期:2016-02-01 00:00:00

  • Cerebrovascular reserve in patients with carotid occlusive disease assessed by stable xenon-enhanced ct cerebral blood flow and transcranial Doppler.

    abstract:BACKGROUND AND PURPOSE:Cerebrovascular reserve (CVR) by both transcranial Doppler ultrasonography (TCD) and quantitative cerebral blood flow (CBF) can identify subgroups of patients at increased risk for stroke. A direct comparison of CVR measurements obtained with both technologies in patients with cerebrovascular occ...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.str.32.8.1811

    authors: Pindzola RR,Balzer JR,Nemoto EM,Goldstein S,Yonas H

    更新日期:2001-08-01 00:00:00

  • Determinants in Adolescence of Stroke-Related Hospital Stay Duration in Men: A National Cohort Study.

    abstract:BACKGROUND AND PURPOSE:Physical and psychological characteristics in adolescence are associated with subsequent stroke risk. Our aim is to investigate their relevance to length of hospital stay and risk of second stroke. METHODS:Swedish men born between 1952 and 1956 (n=237 879) were followed from 1987 to 2010 using i...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.014265

    authors: Bergh C,Udumyan R,Appelros P,Fall K,Montgomery S

    更新日期:2016-09-01 00:00:00

  • Sensory symptoms and signs and results of quantitative sensory thermal testing in patients with lacunar infarct syndromes.

    abstract:BACKGROUND AND PURPOSE:Quantitative data on sensory impairment in stroke patients are limited. We measured the perception thresholds for temperature and thermal pain in patients with different lacunar syndromes, correlated the results with clinical and magnetic resonance imaging (MRI) findings, and studied the long-ter...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.25.11.2165

    authors: Samuelsson M,Samuelsson L,Lindell D

    更新日期:1994-11-01 00:00:00

  • Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats.

    abstract:BACKGROUND AND PURPOSE:Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) are the growth factors regulating hematopoiesis. We have previously observed that SCF and G-CSF have...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.486217

    authors: Zhao LR,Berra HH,Duan WM,Singhal S,Mehta J,Apkarian AV,Kessler JA

    更新日期:2007-10-01 00:00:00

  • Homocysteine and pulsatility index of cerebral arteries.

    abstract:BACKGROUND AND PURPOSE:A pulsatility index (PI) represents vascular resistance distal to an examined artery. The purpose of the present study was to evaluate an association between plasma total homocysteine (tHcy) and PIs of the cerebral arteries in patients with ischemic stroke. METHODS:Consecutive patients with isch...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.109.558403

    authors: Lim MH,Cho YI,Jeong SK

    更新日期:2009-10-01 00:00:00

  • Cellular actions of halothane on cat cerebral arterial muscle.

    abstract::The effects of halothane on intracellular membrane potential (Em) and force development in cat MCA were studied. Halothane (0.07-0.14 mM/1) relaxed isolated MCA which had developed myogenic tone. Measurement of Em showed that halothane depolarized this preparation in a dose-dependent fashion in the face of vessel rela...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.16.4.680

    authors: Harder DR,Gradall K,Madden JA,Kampine JP

    更新日期:1985-07-01 00:00:00

  • Concurrent validity and reliability of retrospective scoring of the Pediatric National Institutes of Health Stroke Scale.

    abstract:BACKGROUND AND PURPOSE:The Pediatric National Institutes of Health Stroke Scale (PedNIHSS), an adaptation of the adult National Institutes of Health Stroke Scale, is a quantitative measure of stroke severity shown to be reliable when scored prospectively. The ability to calculate the PedNIHSS score retrospectively woul...

    journal_title:Stroke

    pub_type: 杂志文章,多中心研究

    doi:10.1161/STROKEAHA.111.633305

    authors: Beslow LA,Kasner SE,Smith SE,Mullen MT,Kirschen MP,Bastian RA,Dowling MM,Lo W,Jordan LC,Bernard TJ,Friedman N,DeVeber G,Kirton A,Abraham L,Licht DJ,Jawad AF,Ellenberg JH,Lautenbach E,Ichord RN

    更新日期:2012-02-01 00:00:00