Abstract:
:The effects of halothane on intracellular membrane potential (Em) and force development in cat MCA were studied. Halothane (0.07-0.14 mM/1) relaxed isolated MCA which had developed myogenic tone. Measurement of Em showed that halothane depolarized this preparation in a dose-dependent fashion in the face of vessel relaxation, demonstrating uncoupling of electrical and mechanical activity. Halothane markedly inhibited the contractile effects of histamine and serotonin suggesting that, apart from its direct action on cerebral arterial tone, it also blunts the action of vasoactive agents. When this preparation is partially depolarized from -62 to -50 mV with excess K+, halothane, while having only a small (1.2 mV) additional depolarizing effect, consistently elicits contraction rather than relaxation. Thus, the action of this particular volatile anesthetic on cerebral arteries can depend upon the resting level of Em. These studies indicate that halothane relaxes myogenic tone in cat MCA by an intracellular mechanism, but that the direction of its effect (i.e., relaxation vs. contraction) may depend upon the prior level of Em and muscle cell activation.
journal_name
Strokejournal_title
Strokeauthors
Harder DR,Gradall K,Madden JA,Kampine JPdoi
10.1161/01.str.16.4.680subject
Has Abstractpub_date
1985-07-01 00:00:00pages
680-3issue
4eissn
0039-2499issn
1524-4628journal_volume
16pub_type
杂志文章相关文献
STROKE文献大全abstract:BACKGROUND AND PURPOSE:Prominent posterior cerebral artery (PCA) laterality upon 3-dimensional time-of-flight magnetic resonance angiography is often encountered in patients with middle cerebral artery occlusion. We hypothesized that this sign is correlated with improved functional outcome in patients with middle cereb...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.112.674101
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Urinary incontinence (UI) is a common and distressing problem after stroke. Although there is evidence of new, effective UI poststroke rehabilitation intervention, it is unknown whether occupational therapists (OTs)' and physical therapists (PTs)' actual practices reflect best practices. We sough...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.486035
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The association between hyperthermia and early neurological deterioration, increased morbidity, and mortality in acute ischemic stroke is well known. However, the timing at which the cerebral lesion may be aggravated by high temperature has not been firmly established. The aim of this study was t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.12.2455
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:It is not known what fraction of patients with symptomatic cerebral aneurysms are misdiagnosed at initial medical presentation. It is also not clear whether misdiagnosed patients more frequently deteriorate before definitive aneurysm diagnosis and therapy or achieve a poorer outcome than correctl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.9.1558
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) are the growth factors regulating hematopoiesis. We have previously observed that SCF and G-CSF have...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.486217
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We previously reported increased incidence of ischemic stroke among both blacks and whites with diabetes mellitus, especially in those aged <55 years. With rising prevalence of diabetes mellitus in the past decade, we revisit the impact of diabetes mellitus on stroke incidence in the same populat...
journal_title:Stroke
pub_type: 杂志文章,多中心研究
doi:10.1161/STROKEAHA.113.001318
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We evaluated the impact of a primary stroke center (PSC) destination policy in a major metropolitan city and used geographic modeling to evaluate expected changes for a comprehensive stroke center policy. METHODS:We identified suspected stroke emergency medical services encounters from 1/1/2004 ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020691
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In perimesencephalic nonaneurysmal hemorrhage (PMH), subarachnoid blood accumulates around the midbrain. Clinical and radiological characteristics suggest a venous origin of PMH. We compared the venous drainage of the midbrain between patients with PMH and aneurysmal subarachnoid hemorrhage (aSAH...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.STR.0000131657.08655.ce
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The efficacy of neuroprotective approaches in stroke may be influenced by existing comorbidities. Here, we compared the effects of normobaric hyperoxia (NBO) in normotensive versus hypertensive rats subjected to transient focal cerebral ischemia. METHODS:Male Sprague-Dawley and spontaneously hyp...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.118.020626
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Prevalence of cerebral microbleeds (CMB) in white and Asian populations range from 4% to 15%. However, there is no information from indigenous Latin American people. We aimed to assess prevalence and cerebrovascular correlates of CMB in stroke-free older adults living in rural Ecuador. METHODS:O...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.009594
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Delayed cerebral infarction (DCI) is an important cause of poor outcome after subarachnoid hemorrhage. Cerebral perfusion is a predictor for DCI. Because acute hydrocephalus may impair cerebral perfusion, we evaluated the predictive value of the extent of acute hydrocephalus on the development of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.484220
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial Doppler ultrasonography (TCD) is the standard technique for monitoring emboli in the cerebral circulation. Embolic signals have been detected with the use of this technique in most patients undergoing coronary artery bypass surgery. We previously reported that the majority of emboli ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.27.1.87
更新日期:1996-01-01 00:00:00
abstract::The effect of very-low-dose aspirin as an antithrombotic agent was evaluated blindly in 301 patients who had recently undergone carotid endarterectomy. After randomization, 150 patients received aspirin and 151 received placebo. The two groups were comparable with regard to age, sex, blood pressure, previous cerebrova...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.19.10.1211
更新日期:1988-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The estimated prevalence of intracranial atherosclerotic disease (IAD) in patients with stenosis of the extracranial internal carotid artery (ICA) varies between 20% and 50%. The benefits of carotid endarterectomy (CE) in patients with both IAD and symptomatic extracranial ICA stenosis are uncert...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.str.30.2.282
更新日期:1999-02-01 00:00:00
abstract::The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke and Intracranial Stenosis (SAMMPRIS) trial, a randomized clinical trial comparing aggressive medical management to stenting with aggressive medical management for symptomatic intracranial stenosis, was prematurely halted when a high rate of...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.111.645507
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Post hoc analyses of randomized controlled clinical trials evaluating mechanical thrombectomy have suggested that admission-to-groin-puncture (ATG) delays are associated with reduced reperfusion rates. Purpose of this analysis was to validate this association in a real-world cohort and to find as...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.120.030208
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The pathogenesis of periventricular hyperintensity (PVH) is still uncertain. We investigated the relationship between PVH and risk factors for cerebrovascular diseases, especially extracranial carotid artery stenosis (ECAS). METHODS:We studied PVH and ECAS in 323 subjects between 1991 and 1994. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.11.2174
更新日期:1997-11-01 00:00:00
abstract::Background and Purpose- We aimed to compare outcomes of ischemic stroke patients with nonvalvular atrial fibrillation between earlier and later initiation of direct oral anticoagulants (DOACs) after stroke onset. Methods- From data for 1192 nonvalvular atrial fibrillation patients with acute ischemic stroke or transie...
journal_title:Stroke
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/STROKEAHA.119.028118
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Lacunes are thought to occur in patients with hypertension or diabetes mellitus as a result of small-vessel disease. This study evaluated the importance of other stroke mechanisms in a population of patients with lacunar infarction. METHODS:We evaluated 108 consecutive patients with a lacune in ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.3.325
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Animal studies of cerebral arteries 2 to 3 days after experimental subarachnoid hemorrhage (SAH) provide evidence of arterial change such as hyperresponsiveness to contractile agonists. There is evidence that small arteries, as well as those large enough to be seen on angiography, may be involved...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.29.12.2575
更新日期:1998-12-01 00:00:00
abstract::As indicated by Barnett, Plum and Walton, a definitive clinical trial to resolve the issue of the effectiveness of carotid endarterectomy is clearly needed. A proposal to foster such a trial, through a moratorium on third-party reimbursement other than for randomized patients, has herein been presented. ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.6.1335
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The results of previous studies suggest that early goal-directed fluid therapy (EGDT) reduces delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but the effects of EGDT on clinical outcomes are still unclear. This study aimed to determine whether EGDT improves outcomes comp...
journal_title:Stroke
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/STROKEAHA.114.004739
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy, which mainly involves the brain causing stroke and dementia. Mice expressing the mutated protein display early dysfunction in vasoreactivity in resistance arteries, b...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.107.490029
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Animal studies have shown that MR diffusion imaging can outline acute ischemic regions before irreversible damage (infarction) occurs. To study evolution of ischemic lesions in humans, it is therefore important to quantify absolute diffusion constants (D values), but quantitation has not been rep...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.28.3.483
更新日期:1997-03-01 00:00:00
abstract::Twenty-four cats had an intravenous infusion of either Fluosol or saline and then were subjected to 2 hours of middle cerebral artery occlusion. All the animals infused with Fluosol and one-half the animals infused with saline were ventilated with 100% O2. Tissue oxygen availability and regional cerebral blood flow we...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.17.5.976
更新日期:1986-09-01 00:00:00
abstract::It is generally stated that ulceration of the carotid bifurcation plaque may give rise to embolization and symptoms of cerebral ischemia. It has been suggested that prophylactic carotid endarterectomy is indicated in asymptomatic patients if the angiogram is interpreted as showing ulceration. We therefore determined t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.14.6.882
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We have shown that acute treatment with candesartan in an experimental model of stroke resulted in vascular protection and improved outcomes at 24 hours poststroke, but the mechanisms are unknown. We now examine effects of candesartan on proangiogenic factors and 7-day outcomes using the same tre...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.108.537225
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We sought to assess the reproducibility, interobserver variability, and application to clinical studies of a new method for the quantitative assessment of carotid plaque echogenicity. METHODS:Carotid plaques were scanned with the use of ultrasound, and their images were stored in a computer. The...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.31.9.2189
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Stroke on board aircraft has been reported in retrospective case series, mainly focusing on economy class stroke syndrome. Data on the actual incidence, pathogenesis, and prognosis of stroke in commercial flights are lacking. METHODS:A prospective registry was designed to include all consecutive...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/STROKEAHA.115.012637
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Several hundred studies have been published over the last few years on imaging and measurement of carotid stenosis. Despite all this research, there is still no consensus about how best to image and measure stenosis. One possible explanation for this is that many of the studies have not been larg...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.31.6.1444
更新日期:2000-06-01 00:00:00