Postoperative pain after local anesthetics for laparoscopic sterilization.

Abstract:

OBJECTIVE:To test the effectiveness of intraperitoneal local anesthesia in relieving postoperative pain after laparoscopic sterilization. METHODS:In a double-blind, placebo-controlled randomized study of two groups of 25 subjects each, women scheduled for tubal sterilization under general anesthesia received 80 mL of 0.5% lidocaine with 1/320,000 epinephrine intraperitoneally in the right subdiaphragmatic quadrant at the beginning of the procedure. At the end of the procedure, they received 10 mL of 2% lidocaine with 1/80,000 epinephrine injected into each mesosalpinx. Controls received saline instead of lidocaine. Shoulder and pelvic pain assessed by visual analogue pain scale, postoperative analgesic requirements, nausea or vomiting, and time to return to normal daily activities were evaluated in the ambulatory unit and after discharge during the first 48 postoperative hours. Blood samples were taken in ten subjects receiving lidocaine to evaluate peak plasma concentrations and time to peak plasma concentrations. RESULTS:Pain was significantly less in patients who received lidocaine, and the difference lasted for the duration of the study (P < .05). Analgesic requirements and time to return to normal daily activities were significantly reduced in patients who received lidocaine (P < .05). Blood samples revealed no toxic concentrations. The peak plasma concentration was 3.22 +/- 1.21 micrograms/mL, and the time to peak plasma concentration was 42 +/- 15 minutes. CONCLUSION:Intraperitoneal instillation of lidocaine-epinephrine combined with mesosalpinx infiltration of lidocaine during tubal sterilization produces effective, long-lasting analgesia and improves the postoperative course.

journal_name

Obstet Gynecol

authors

Benhamou D,Narchi P,Mazoit JX,Fernandez H

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

877-80

issue

5

eissn

0029-7844

issn

1873-233X

journal_volume

84

pub_type

临床试验,杂志文章,随机对照试验
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    doi:

    authors: Buyalos RP,Rutanen EM,Tsui E,Halme J

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    pub_type: 杂志文章,meta分析

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    pub_type: 杂志文章,随机对照试验

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    doi:

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    pub_type: 杂志文章

    doi:

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,实务指引

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    pub_type: 杂志文章

    doi:

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    pub_type: 杂志文章

    doi:

    authors: Farrell SJ

    更新日期:1983-09-01 00:00:00

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Serra GB,Muscatello P,Menini E,Lafuenti G,Caniglia R

    更新日期:1975-05-01 00:00:00

  • The Rise and Fall of Mesh in Pelvic Surgery and the Shortcomings of Medical Device Regulation.

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    pub_type: 社论

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    pub_type: 杂志文章

    doi:

    authors: Tunca J,Palmer A,Nahmias A,Mihalik K,Naib Z,London W,Sever J

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    pub_type: 杂志文章

    doi:

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    更新日期:1985-11-01 00:00:00

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    doi:

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    更新日期:1979-02-01 00:00:00

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    pub_type: 杂志文章,评审

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