Abstract:
BACKGROUND:The clinical importance of point mutations of ras oncogene in differentiated thyroid cancers has not been fully clarified. The purpose of this study is to determine the prognostic importance of ras mutation in papillary thyroid carcinoma. METHODS:Tumors of 91 patients with papillary carcinoma were studied; mean follow-up was 14.1 years (range, 1 to 40 years). Patients were grouped as follows: class I, intrathyroidal disease, n = 21; class II, cervical node metastases, n = 22; class III, extrathyroidal disease, n = 19; and class IV, distant metastases, n = 29. DNA was analyzed with polymerase chain reaction, oligonucleotide hybridization, and DNA sequence analysis techniques. RESULTS:Thirteen (14.3%) of 91 tumors showed an N-ras point mutation: 4.8% (1 of 21) patients in class I; 4.5% (1 of 22) patients in class II; 15.8% (3 of 19) patients in class III; and 27.8% (8 of 29) patients in class IV. Each mutation changed codon 61 from glutamine to arginine. Patients with distant metastases (8 of 29) had a significantly higher incidence of ras mutations than others (5 of 62, p = 0.01). Patients in classes III and IV also had a higher incidence of mutations (11 of 48) than patients in classes I and II (2 of 43, p = 0.01). The incidence of ras mutations was significantly higher in patients who died of papillary cancer (5 of 15, 33.3%) than in patients who are still alive (8 of 76, 10.5%) (p = 0.02). Kaplan-Meier survival curves also showed a greater mortality from tumor (p < 0.05) and a higher recurrence rate (p < 0.01) in ras-positive tumors than in the ras-negative group. Finally, in studies by multivariate analyses, positive ras mutation and age were shown to be two independent prognostic factors for prediction of death from papillary cancer and recurrence of cancer. CONCLUSIONS:Mutation of N-ras gene at codon 61 is an independent prognostic factor for aggressiveness of papillary thyroid carcinomas.
journal_name
Surgeryjournal_title
Surgeryauthors
Hara H,Fulton N,Yashiro T,Ito K,DeGroot LJ,Kaplan ELsubject
Has Abstractpub_date
1994-12-01 00:00:00pages
1010-6issue
6eissn
0039-6060issn
1532-7361pii
0039-6060(94)90297-6journal_volume
116pub_type
杂志文章相关文献
SURGERY文献大全abstract:BACKGROUND:Resection for hepatocellular carcinoma in patients with cirrhosis and impaired liver function is usually unjustified because of higher surgical risks and poorer long-term prognosis. METHODS:A retrospective comparison of the background and resectional results of patients with cirrhosis and hepatocellular car...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80238-8
更新日期:1996-07-01 00:00:00
abstract::This study examined whether treatment with the oxygen free radical scavengers, superoxide dismutase and catalase, could improve functional recovery in hearts subjected to regional ischemia and global cardioplegic arrest. Regional left ventricular (LV) function was assessed in open chest pigs with sonomicrometry and mi...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Liver cell proliferation after partial hepatectomy in rats has been thoroughly investigated. Although DNA synthesis and morphologic restoration have been studied in this rat model, the functional capacity of the remnant liver during regeneration has not been elucidated. METHODS:We measured the indocyanine g...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90058-1
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:Coronary artery bypass grafting surgery has an increased risk of adverse events in obese patients. This increased risk might be explained in part by an increased intra-abdominal pressure and the development of intra-abdominal hypertension. Therefore, the objective of this study was to investigate the correla...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.05.038
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Microvascular invasion is the strongest prognostic factor of survival in patients with hepatocellular carcinoma. We therefore developed a predictive model for microvascular invasion of hepatocellular carcinoma to help guide treatment strategies in patients scheduled for either hepatic resection or liver tran...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.01.012
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:The objectives of the present study are to determine the long-term changes in glucose tolerance function after pancreaticoduodenectomy and to compare the effects of pancreaticojejunostomy (PJ) and pancreaticogastrostomy (PG). Patients and methods The present study consisted of 51 patients who received a panc...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.01.006
更新日期:2004-09-01 00:00:00
abstract::An independent study program (ISP) was instituted in 1970 for a group of 32 preclerkship medical students picked randomly from a group of 64 volunteers. The academic achievements of these classes, as measured by mean National Board scores, is compared with their classmates in the lecture discussion (LD) program where ...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1977-06-01 00:00:00
abstract::Using software to transform magnetic resonance imaging (MRI) tomographic data into three-dimensional projections, we have produced "angiograms" of the abdominal aorta in 18 patients with occlusive (15) and aneurysmal (3) disease. This information may be displayed to demonstrate flow, cross-sectional diameter, or aorti...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion injury of skeletal muscle is a common clinical and experimental problem. To date, there has been no uniform and reproducible method to assess the extent of histologic injury. In this study, we developed a novel statistical methodology for evaluating injury in individual myocytes and 3 di...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.06.005
更新日期:2008-01-01 00:00:00
abstract::The multiple endocrine neoplasia (MEN) IIb syndrome has been differentiated from MEN IIa by the presence of various phenotypic characteristics such as mucosal neuromas, marfanoid habitus, congenital skeletal anomalies, and prominent corneal nerves, as well as the lack of parathyroid involvement. Analysis of a kindred ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:Vaccination of tumor-bearing animals with tumor cells genetically engineered to secrete cytokines including interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) has been shown to induce effective tumor-specific immune responses capable of inhibiting local and metastatic disease. Previous unsuccessful attemp...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80285-6
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Classic surgical treatment of upper third gastric carcinoma is based on an extended total gastrectomy, including splenectomy. The purpose of this study was to perform a prospective randomized clinical trial comparing the early and late results of total gastrectomy (TG) versus total gastrectomy plus splenecto...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1067/msy.2002.121891
更新日期:2002-04-01 00:00:00
abstract::Efforts to produce a clinically acceptable hemoglobin solution that could function as a temporary oxygen carrier have evolved through several stages. Beginning with the simple tetramer, we have lowered the affinity state by pyridoxylation and then polymerized the modified tetramer. This new substance, polyhemoglobin, ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Venous thromboembolism, presenting as deep vein thrombosis or pulmonary embolism, can be associated with considerable morbidity after major abdominal and pelvic surgery. Perioperative thromboprophylaxis with low-molecular-weight heparin is well established, but the duration of treatment remains debated. We a...
journal_title:Surgery
pub_type: 杂志文章,meta分析
doi:10.1016/j.surg.2018.05.028
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Cigarette smoke and nicotine are among the leading environmental risk factors for developing pancreatic ductal adenocarcinoma (PDA). We showed recently that nicotine induces osteopontin (OPN), a protein that plays critical roles in inflammation and tumor metastasis. We identified an OPN isoform, OPNc, that i...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.05.002
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Adenosine released by cells during ischemia typically serves as a feedback inhibitor of further organ work. However, in ischemic intestine, adenosine appears to act via stimulatory A2b receptors to increase work in the form of chloride ion (Cl-) secretion. This unusual response may contribute to luminal flui...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80295-9
更新日期:1996-08-01 00:00:00
abstract::Computed tomography was used to evaluate 25 hemodynamically stable patients with suspected leaking abdominal aortic aneurysms. Of 10 patients found to have the presence of free retroperitoneal blood, six underwent immediate operation and five survived (83%). Delay in operation uniformly resulted in death. There was on...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::A case report of a patient with Marfan's syndrome who developed acute supravalvular aortic stenosis following aortic valve replacement and reconstruction of the ascending aorta is presented. Early recognition of this complication permitted reoperation and successful repair. One similar case has been reported previousl...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Giant duodenal ulcer (GDU) is generally thought to require surgical intervention. Proton pump inhibitors have beneficial effects in peptic ulcer disease, but their role in GDU disease is unknown. We examined the use of omeprazole in GDU management. METHODS:Twenty-eight patients were diagnosed with GDU. One ...
journal_title:Surgery
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::The experience with 14 patients with infected aortic bifurcation grafts has been reviewed. Factors which appeared to predispose to infection in 11 patients included "re-do" operations, concomitant cholecystectomy or gastrostomy, and ruptured abdominal aneurysm. A mixture of gastrointestinal organisms was responsible f...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:Burn-induced compartment syndrome is a severe sequela after circumferential burns of the extremities and is avoidable by immediate release of the underlying pressure under the eschar. Although the current gold standard is operative escharotomy, this procedure carries considerable morbidity. Our study evaluat...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.11.019
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Oxidative stress and inflammation are implicated in the pathogenesis of steatohepatitis. We hypothesize that Roux-en-Y gastric bypass reduces oxidative stress and inflammation in the liver of obese rats via activation of AMPK-α. METHODS:Obese Sprague-Dawley male rats underwent either sham operation or Roux-...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.01.012
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Outcome for most abdominal wall defects is related to the presence or absence of additional anomalies or prematurity. In gastroschisis, outcome is almost as closely related to the severity of the inflammatory "peel" on bowel that is thought to result from direct contact with amniotic fluid. Improving eviscer...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Perirectal and perineal infections represent a life-threatening complication of hematologic diseases associated with granulocytopenia. Early and aggressive surgical management is essential. This should include hemodynamic support and monitoring, broad-spectrum antibiotics, wide surgical debridement, and a totally dive...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Operative therapy for Crohn's disease (CD) recurrence is supposed to be more complex and demanding than primary resection. The purpose of this study was to assess a postoperative course after reoperation for the recurrence of CD. METHODS:From 1998 to 2008, 61 patients underwent reoperation for the recurrenc...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.02.001
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Although intracellular protease activation is thought to be an early event in acute pancreatitis, factors determining progression from edematous to necrotizing pancreatitis are largely unknown. With enterokinase as a probe and an immunoassay quantifying free trypsinogen activation peptides (TAP), we sought e...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Very late activation-2 (VLA-2) is an integrin receptor for laminin that consists of an alpha 2- and a beta 1-subunit. In human breast cancer, down-regulation of VLA-2 expression is related to positive nodal status. The functional significance of altered integrin expression in individual patients has never be...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(05)80330-7
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:The present study evaluates 111In-pentetreotide scanning as a method for detection of gastrinomas. Operative findings serve as the benchmark for comparison of the efficacy of 111In-pentetreotide versus conventional imaging studies. METHODS:Twelve patients (seven female and five male; age, 37 to 80 years) wi...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(05)80121-7
更新日期:1995-12-01 00:00:00
abstract::One hundred sixty patients had preoperative mediastinoscopy, resection of the primary tumor, and complete mediastinal lymphadenectomy for non-small-cell carcinoma of the lung. Minimum follow-up was 24 months (mean 40 months). Postoperative staging based on histologic examination of the specimen of the lung and mediast...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Prolonged warm ischemic injury in non-heart-beating donors (NHBDs) significantly affects hepatic allograft function after liver transplantation (LTx). METHODS:The effects of FK506 and the platelet activating factor antagonist E5880 on postoperative function of hepatic allografts procured from NHBDs were eva...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00