Abstract:
BACKGROUND:Prolonged warm ischemic injury in non-heart-beating donors (NHBDs) significantly affects hepatic allograft function after liver transplantation (LTx). METHODS:The effects of FK506 and the platelet activating factor antagonist E5880 on postoperative function of hepatic allografts procured from NHBDs were evaluated in porcine orthotopic LTx. In donors, livers were subjected to 90 minutes of warm ischemia and a subsequent 4-hour cold preservation. Group 1 (n = 6) was the untreated control group. In group 2 (n = 4), donors were pretreated with FK506 (0.3 mg/kg). In group 3 (n = 4), donors and recipients were treated with E5880 (0.3 mg/kg). In group 4 (n = 6), pigs were treated with both FK506 and E5880. RESULTS:All of the recipients in group 1 died within 12 hours. In groups 2 and 3, half of the recipients survived more than 12 hours. In group 4, all of the recipients survived more than 2 days (p < 0.01 compared with group 1). The improved survival seen in group 4 was associated with a reduction in the serum concentrations of glutamic oxaloacetic transaminase and lactate, and a restoration of hepatic energy charge. CONCLUSIONS:The present study suggests that FK506 and E5880 can improve the function of hepatic allografts subjected to prolonged warm ischemia in NHBDs, and that the protective effects of the two drugs seem to be synergistic.
journal_name
Surgeryjournal_title
Surgeryauthors
Takada Y,Taniguchi H,Fukunaga K,Yuzawa K,Otsuka M,Todoroki T,Iijima T,Fukao Ksubject
Has Abstractpub_date
1998-06-01 00:00:00pages
692-8issue
6eissn
0039-6060issn
1532-7361pii
S0039-6060(98)70207-7journal_volume
123pub_type
杂志文章相关文献
SURGERY文献大全abstract:PURPOSE:Enhancer of zeste homologue 2 (EZH2), a component of the chromatin modification protein complex, is upregulated in pancreatic ductal adenocarcinoma (PDAC), whereas loss of p53 and its downstream target, p21(waf1/cip1), is also observed frequently. We sought to investigate the role of the p53-p21(waf1/cip1) path...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2013.06.041
更新日期:2013-10-01 00:00:00
abstract::Diffuse compensatory extramedullary hematopoiesis is well known to involve the spleen and liver in certain hematologic disorders. Hematopoietic tumor masses occasionally form and usually occur paraspinally in the posterior mediastinum. A 31-year-old patient with thalassemia is described with a massive, solitary, intra...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Hepatectomy for colorectal liver metastases (CRLM) may offer good long-term survival. The impact of the tumor-free surgical margin on long-term results remains controversial, and we have assessed this component in 185 patients. METHODS:Between 1992 and 2005, 185 patients underwent primary hepatectomy with c...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.09.038
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether intraoperative parathyroid hormone (IOPTH) assay improved results of reoperations. METHODS:One hundred two patients with persistent/recurrent sporadic primary hyperparathyroidism underwent 108 reoperations (1996-2002). IOPTH was not used (n=58) from 1996-19...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2003.08.007
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:The surgical management and follow-up strategy in patients with medullary thyroid carcinoma (MTC) remain controversial because of the lack of data on the natural history of these tumors and their patterns of progression. METHODS:We reviewed the records of all patients who underwent a cervical operation for ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(03)00408-2
更新日期:2003-12-01 00:00:00
abstract::The early work of Dr. William Longmire with total gastrectomy for gastric carcinoma prompted us to initiate an aggressive surgical approach to gastric carcinoma in 1960: in curative resections radical total gastrectomy with hepaticoceliac-left gastric arterial node dissection was to be performed for tumors involving t...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine if team training using a federally sponsored team training program improves operating room (OR) performance and culture. METHODS:The TeamSTEPPS program, a team training program designed and tested for health care applications, was provided to the OR staff. The training ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2011.07.076
更新日期:2011-10-01 00:00:00
abstract::The use of a modified bovine collagen graft as a low-pressure conduit was investigated by implantation into the iliocaval system of dogs. In the 210 day observation period, a patency rate of 87.5% was achieved. Nearly all graft failures occured within the first 14 days following implantation; failure after that time d...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1978-11-01 00:00:00
abstract::Two cases are reviewed here that highlight the utility of minimally invasive surgery (MIS) techniques in major surgery procedures involving the liver. They also demonstrate specific operative procedures once thought beyond the scope of the MIS surgeon, but they are now standard in expert hands. Improved methods for at...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2007.08.008
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:In an attempt to prevent overly aggressive treatment of low-risk thyroid cancers, the American Thyroid Association changed guideline recommendations in late 2015 to state that either hemithyroidectomy or total thyroidectomy are acceptable operations for these patients. We hypothesized that surgeons would inc...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.03.002
更新日期:2019-09-01 00:00:00
abstract::Severe abdominal pain was the major indication for operation in 85 patients with chronic pancreatitis. Preoperative endoscopic retrograde cholangiopancreatography (50 patients) or intraoperative pancreatic ductograms (44 patients) demonstrated dilated or obstructed major pancreatic ducts in 50 patients (59%), nonvisua...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-10-01 00:00:00
abstract::The incidence of fascial disruption after major abdominal operations is 1% to 3%, and dehiscence is associated with a mortality rate of 15% to 20%. Although several systemic factors (e.g., malnutrition, increased age, male sex, and chronic treatment with steroids) have been associated with an increased risk of wound d...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Outcome for most abdominal wall defects is related to the presence or absence of additional anomalies or prematurity. In gastroschisis, outcome is almost as closely related to the severity of the inflammatory "peel" on bowel that is thought to result from direct contact with amniotic fluid. Improving eviscer...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Long-term outcomes after face transplantation are rarely reported in the scientific literature. Here we present outcome data of a partial face allograft recipient 10 years after transplantation. METHODS:Medical records were reviewed for functional and psychosocial outcomes as well as complications. Histopat...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.01.010
更新日期:2020-06-01 00:00:00
abstract::Blood flow and pressures around a canine femoral arteriovenous fistula, constructed from an autogenous carotid artery, were measured to determine the pressure-flow relationships within the fistula, as well as to determine the presence or absence of retrograde flow in the distal artery and vein. The findings indicate ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:Emergency medical services are important to the functioning of health systems, but these services tend to be neglected in low- and middle-income countries, such as India. In recent years, several models of pre-hospital emergency medical services have emerged in India. Research on these models holds important...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.01.026
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The goal of the current study is to characterize the presentation, therapy, and outcomes of acute limb ischemia (ALI) associated with type B aortic dissection (AoD). METHODS:The prospective/retrospective International Registry for Acute Aortic Dissection (IRAD) database and a single institutional database w...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2006.06.019
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Despite the emphasis on medical error as a major cause of hospital morbidity and mortality, there has been little published work on errors committed by trainees. This issue is particularly relevant to the training of surgeons and was addressed by our study. METHODS:Sixty simulated laparoscopic cholecystecto...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.02.014
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Cytologically indeterminate thyroid nodules represent a diagnostic and therapeutic challenge. In 2007, the National Cancer Institute recommended The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) as a means of improving the accuracy of thyroid cytopathology. Our objective was to determine the e...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.09.017
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Interest is growing in simulation-based continuing medical education courses for practicing surgeons. However, little research has explored the instruction employed during these courses. This study examines instruction practices used during an annual simulation-based continuing medical education course. MET...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.01.016
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Age-related loss of muscle mass and function (sarcopenia) is linked to poor outcomes after operation and trauma. Here we evaluate computed tomography measured psoas muscle density and area using quick and simple tools available to the bedside clinician. We hypothesize these measures will predict poor outcome...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.03.014
更新日期:2017-08-01 00:00:00
abstract::To prevent aneurysm rupture, avoid pseudoaneurysm formation, and preserve intercostal arteries, a new procedure for repair of DeBakey type 3 dissecting aneurysm was developed. Since January 1977, 28 patients have undergone repair of type 3 dissecting aneurysm. Fifteen patients with type 3b underwent this new procedure...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The efficacy of octreotide in the regulation of endocrine tumor secretion and symptomatology has been well documented. Its effects on neuroendocrine tumor generation and cell proliferation are less well understood. The purpose of this study was to determine if blockade of somatostatin receptors by octreotide...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Serum concentrations of fatty acid binding protein 4, an adipose tissue fatty acid chaperone, have been correlated with insulin resistance and cardiovascular risk factors. The objective of this study were to assess relationships among Roux-en-Y gastric bypass, intensive lifestyle modification and medical man...
journal_title:Surgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.surg.2018.08.007
更新日期:2019-03-01 00:00:00
abstract::The immunoregulatory events leading to the generation of suppressor T cells after burn injury were studied by means of a mouse burn model. Immunoresponsiveness was assessed on various postburn days with a primary in vitro mixed lymphocyte reaction (MLR). Responses of burned mice were depressed between 3 and 14 days af...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-06-01 00:00:00
abstract:BACKGROUND:Routine central lymph node dissection (CLND) for papillary thyroid cancer (PTC) at the time of initial thyroidectomy has been advocated with a demonstrated decrease in post-ablation serum thyroglobulin compared to total thyroidectomy alone. Patients now present with central compartment metastatic disease aft...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.01.013
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Acupuncture is a safe and well-tolerated treatment for pain relief. Previous studies supported the effectiveness of several acupuncture techniques for postoperative pain. The aim of this randomized, controlled trial was to evaluate the efficacy of acupuncture in reducing pain after thyroid surgery. METHODS:...
journal_title:Surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.surg.2014.08.062
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Little is known about the clinical significance and risk factors for incomplete liver restoration after partial hepatectomy, which is defined by a liver volume restoration of less than 100% of the original volume. METHODS:We retrospectively analyzed patients who underwent hepatic resection for liver tumors ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.02.022
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Telomerase reverse transcriptase promoter mutations were recently found to be associated with poorer prognosis in patients with papillary thyroid carcinoma. Correlation between telomerase reverse transcriptase messenger RNA expression and survival of patients with papillary thyroid carcinoma has not been det...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.04.054
更新日期:2021-01-01 00:00:00
abstract::It is now well accepted that mesoatrial bypass is an efficient treatment of Budd-Chiari syndrome and that it is indicated when the inferior vena cava is obstructed. This report presents a patient in whom the superior mesenteric vein was thrombosed after a previous mesocaval shunt. A bypass was constructed between the ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00