Abstract:
:Efforts to produce a clinically acceptable hemoglobin solution that could function as a temporary oxygen carrier have evolved through several stages. Beginning with the simple tetramer, we have lowered the affinity state by pyridoxylation and then polymerized the modified tetramer. This new substance, polyhemoglobin, has a normal oxygen capacity and a half-life of 38 hours. Issues of nephrotoxicity and immunocompetence after infusion remain to be defined.
journal_name
Surgeryjournal_title
Surgeryauthors
Moss GS,Gould SA,Sehgal LR,Sehgal HL,Rosen ALsubject
Has Abstractpub_date
1984-03-01 00:00:00pages
249-55issue
3eissn
0039-6060issn
1532-7361journal_volume
95pub_type
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