Hemoglobin solution--from tetramer to polymer.

Abstract:

:Efforts to produce a clinically acceptable hemoglobin solution that could function as a temporary oxygen carrier have evolved through several stages. Beginning with the simple tetramer, we have lowered the affinity state by pyridoxylation and then polymerized the modified tetramer. This new substance, polyhemoglobin, has a normal oxygen capacity and a half-life of 38 hours. Issues of nephrotoxicity and immunocompetence after infusion remain to be defined.

journal_name

Surgery

journal_title

Surgery

authors

Moss GS,Gould SA,Sehgal LR,Sehgal HL,Rosen AL

subject

Has Abstract

pub_date

1984-03-01 00:00:00

pages

249-55

issue

3

eissn

0039-6060

issn

1532-7361

journal_volume

95

pub_type

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