The outer membrane protein, LamB (maltoporin), is a versatile vaccine candidate among the Vibrio species.

abstract：:Salmonella strains have great potential as live carriers of heterologous antigens to induce immunity against a variety of infectious diseases. However, the amount of heterologous antigen required to induce an adequate immune response may be toxic for the bacterium and result in cell death, overattenuation or loss of e...

journal_title：Vaccine

authors： Tijhaar EJ,Zheng-Xin Y,Karlas JA,Meyer TF,Stukart MJ,Osterhaus AD,Mooi FR

更新日期：1994-08-01 00:00:00

abstract：:SPf66 is the first chemically synthesised vaccine to elicit a partial protective immune response against malaria. The aluminium hydroxide (alum)-adsorbed SPf66 vaccine is weakly immunogenic and of poor to moderate efficacy in humans. To investigate the possibility of improving SPf66 vaccine immunogenicity, a delivery ...

journal_title：Vaccine

authors： Rosas JE,Hernández RM,Gascón AR,Igartua M,Guzman F,Patarroyo ME,Pedraz JL

更新日期：2001-08-14 00:00:00

abstract：BACKGROUND:While childhood vaccines are safe and effective, some parents remain hesitant to vaccinate their children, which has led to outbreaks of vaccine preventable diseases. The goal of this systematic review was to identify and summarize the range of beliefs around childhood vaccines elicited using open-ended ques...

journal_title：Vaccine

authors： Gidengil C,Chen C,Parker AM,Nowak S,Matthews L

更新日期：2019-10-23 00:00:00

abstract：:Data from two Swedish pertussis vaccine trials with various combination vaccines were used to compare anti-diphtheria antitoxin concentrations over time between different vaccines, vaccine lots and vaccine schedules. The immune responses were measured with a validated ELISA method.Results are given for 1326 children, ...

journal_title：Vaccine

authors： Tiru M,Hallander HO,Gustafsson L,Storsaeter J,Olin P

更新日期：2000-04-28 00:00:00

abstract：:Vaccine adjuvants are essential for enhancing immune responses during vaccination. However, only a limited number of safe and effective adjuvants, especially mucosal adjuvants, are available for use in vaccines. The development of a practically applicable mucosal adjuvant is therefore urgently needed. Here, we showed ...

journal_title：Vaccine

authors： Fan X,Su Q,Qiu F,Yi Y,Shen L,Jia Z,Liang P,Zou Y,Bi S

更新日期：2018-07-05 00:00:00

abstract：OBJECTIVE:This case-control study investigated the relationship between the risk of Autism Spectrum Disorder (ASD) onset, and early exposure to the combined Measles-Mumps-Rubella (MMR) vaccine and thimerosal consumption measured from vaccinations in the highly genetically homogenous Japanese population. METHODS:Vaccin...

journal_title：Vaccine

authors： Uno Y,Uchiyama T,Kurosawa M,Aleksic B,Ozaki N

更新日期：2015-05-15 00:00:00

abstract：:Since smallpox eradication by the WHO during the 1980s, potency of new vaccines is compared to vaccines that were used during the eradication campaign. In this work we characterize the tail scarification technique in mice as a model for scarification in humans. Similar to humans, mice develop "clinical take" which is ...

journal_title：Vaccine

authors： Melamed S,Paran N,Katz L,Ben-Nathan D,Israely T,Schneider P,Levin R,Lustig S

更新日期：2007-11-07 00:00:00

abstract：BACKGROUND:Haemophilus influenzae type b (Hib) conjugate vaccines have significantly limited Hib's disease impact in every country where it was introduced. We previously estimated invasive Hib disease incidence in Singapore at ∼4.4 per 100,000 children <5 years (from 1994 to 2003, period 1), but the vaccine was not inc...

journal_title：Vaccine

authors： Thoon KC,Tee NW,Chew L,Chong CY

更新日期：2014-10-07 00:00:00

abstract：BACKGROUND:Influenza vaccination is recommended for immunocompromised patients. METHODS:Children (6 months to 21 years) with cancer, HIV infection, or sickle cell disease (SCD) received 1 or 2 doses of pandemic 2009 H1N1 monovalent influenza vaccine (H1N1 MIV). Safety and tolerability, hemagglutination inhibition (HI)...

journal_title：Vaccine

authors： Hakim H,Allison KJ,Van De Velde LA,Li Y,Flynn PM,McCullers JA

更新日期：2012-01-20 00:00:00

abstract：:Liposome and cholera toxin (CT) are considered to be effective antigen delivery vehicles and adjuvants for mucosal vaccines. The effect of these antigen delivery systems on adjuvant responses to mucosally administered pneumococcal polysaccharide (Pnup) was investigated in this study. Both mucosal (e.g. oral) and syste...

journal_title：Vaccine

authors： VanCott JL,Kobayashi T,Yamamoto M,Pillai S,McGhee JR,Kiyono H

更新日期：1996-04-01 00:00:00

abstract：:A rapid and sensitive assay using surface plasmon resonance (SPR) immunoassay has been developed for the detection of Clostridium perfringens beta-toxin. The SPR immunoassay was conducted off-line by passing fermentation broth by a sensor chip coated with a monoclonal antibody specific for C. perfringens beta-toxin. Q...

journal_title：Vaccine

authors： Hsieh HV,Stewart B,Hauer P,Haaland P,Campbell R

更新日期：1998-05-01 00:00:00

abstract：:Previous work by our laboratory identified a fraction of Schistosoma mansoni soluble adult worm antigenic preparation, designated PIII, able to elicit significant in vitro cell proliferation, and lower in vitro and in vivo granuloma formation. In the present work, we investigated some biological activities of P24, an ...

journal_title：Vaccine

authors： Zouain CS,Gustavson S,Oliveira SC,Azevedo V,Alves JB,Goes AM

更新日期：2000-12-08 00:00:00

abstract：:As a follow-up to the first AfroREB meeting, held in Grand Bassam (Côte d'Ivoire) in March 2008, African rabies experts of the AfroREB network met a second time to complete the evaluation of the rabies situation in Africa and define specific action plans. About 40 French speaking rabies specialists from northern, west...

journal_title：Vaccine

authors： Dodet B,Africa Rabies Bureau (AfroREB).

更新日期：2009-08-13 00:00:00

abstract：:In a Phase 2a trial of the RTS,S/AS vaccine, we described significant association between protection against infection and vaccine-induced CD4 T cells. To determine whether processing of the circumsporozoite protein as a component of the RTS,S particulate antigen yields the same HLA-DR-restricted epitopes as those rec...

journal_title：Vaccine

authors： Schwenk R,Lumsden JM,Rein LE,Juompan L,Kester KE,Heppner DG,Krzych U

更新日期：2011-11-08 00:00:00

abstract：:Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the N-terminal 80% E and the other expressing prM and full length E were immunogenic...

journal_title：Vaccine

authors： Raviprakash K,Kochel TJ,Ewing D,Simmons M,Phillips I,Hayes CG,Porter KR

更新日期：2000-05-08 00:00:00

abstract：INTRODUCTION:Vaccination of health care workers (HCW) reduces transmission of influenza among patients, yet uptake of vaccination remains low. If vaccination education is integrated into the early medical school curriculum, will student attitudes toward the vaccine change? The objectives of the study were to: (1) Deter...

journal_title：Vaccine

authors： Afonso N,Kavanagh M,Swanberg S

更新日期：2014-01-16 00:00:00

abstract：:Influenza A viruses pose a substantial threat to the human population whether by purposeful manipulation and release or by the natural process of interspecies transmissions from animal reservoirs. The challenge with preparing for these events with vaccination strategies is that the best forms of protective immunity ta...

journal_title：Vaccine

authors： Ellebedy AH,Webby RJ

更新日期：2009-11-05 00:00:00

abstract：:Behcet's disease (BD) is a chronic, recurrent, inflammatory, multisystemic disorder characterized primarily by vasculitis. The etiopathogenesis of BD involves immunogenetics, infectious organisms (streptococcus, herpes simplex virus), immunoregulation and vascular dysfunctions. We previously found that immunoregulatio...

journal_title：Vaccine

authors： Lee SI,Kwon HJ,Lee ES,Yang BC,Bang D,Lee S,Sohn S

更新日期：2007-10-10 00:00:00

abstract：:In order to establish a firm preventive measure for tick-borne encephalitis (TBE) in Japan, we evaluated the immune response of European vaccine against Japanese TBE virus strain (Oshima 5-10) for man and mouse. Furthermore, the efficacy of pre- and post-exposure protection by a polyclonal rabbit anti-TBE virus serum ...

journal_title：Vaccine

authors： Chiba N,Osada M,Komoro K,Mizutani T,Kariwa H,Takashima I

更新日期：1999-03-17 00:00:00

abstract：:Finding adjuvants in order to enhance immune responses against target immunogens has been a major and recurrent issue for the vaccine industry. It is yet to be solved, most particularly in the context of a growing interest in designing new types of vaccines capable of eliciting Th1 immune responses. A review of synthe...

journal_title：Vaccine

authors： Moingeon P,Haensler J,Lindberg A

更新日期：2001-08-14 00:00:00

abstract：:A synthetic T cell immunogen (TCI) has been designed as a candidate DNA-based vaccine against Human immunodeficiency virus (HIV)-1 using cytotoxic T lymphocytes (CD8(+) CTL) and T-helper lymphocytes (CD4(+) Th) epitopes retrieved from the Los Alamos HIV Molecular Immunology Database. The protein 392 amino acids in len...

journal_title：Vaccine

authors： Bazhan SI,Belavin PA,Seregin SV,Danilyuk NK,Babkina IN,Karpenko LI,Nekrasova NA,Lebedev LR,Ignatyev GM,Agafonov AP,Poryvaeva VA,Aborneva IV,Ilyichev AA

更新日期：2004-04-16 00:00:00

abstract：:The adjuvant properties of polyglucosamine/squalene-based nanocapsules (PG-nanocapsules) associated with different subunit antigens has been previously reported. Thus, the aim of the present study was to monitor the biodistribution of PG-nanocapsules and their affinity for the draining lymph nodes after subcutaneous (...

journal_title：Vaccine

authors： Vicente S,Goins BA,Sanchez A,Alonso MJ,Phillips WT

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:Influenza vaccination among health-care workers is poor, and the effectiveness of hospital vaccination programs remains unclear. Little is known about the effectiveness of intensive evidence-based vaccination programs in nursing staff. We determined whether the recommended vaccination rate could be achieved ...

journal_title：Vaccine

authors： Norton SP,Scheifele DW,Bettinger JA,West RM

更新日期：2008-06-02 00:00:00

abstract：:Preventive immunization against HIV-1 infection requires a rapid immune response that does not rely exclusively on B or T cell memory. Innate immunity may fulfill this function as it may be activated directly at the time of HIV-1 transmission, inhibit early HIV-1 replication, stimulate adaptive immunity and enable spe...

journal_title：Vaccine

authors： Lehner T,Wang Y,Pido-Lopez J,Whittall T,Bergmeier LA,Babaahmady K

更新日期：2008-06-06 00:00:00

abstract：:Cysteine peptidases (CPs) have been implicated in various processes central to the pathogenicity of Leishmania parasites, and are thought to be key factors in the host-parasite interaction. In order to fully evaluate the potential of the CPs as vaccine candidates, studies in natural host species are required. In the s...

journal_title：Vaccine

authors： Poot J,Spreeuwenberg K,Sanderson SJ,Schijns VE,Mottram JC,Coombs GH,Vermeulen AN

更新日期：2006-03-24 00:00:00

abstract：:Infection of rubella virus at the early stages of pregnancy in women who are not immune to rubella often induces congenital anomalies in infants, namely congenital rubella syndrome (CRS). This paper is the first comprehensive report of CRS cases in Japan, compiled from a questionnaire to major hospitals, reports to jo...

journal_title：Vaccine

authors： Katow S

更新日期：2004-09-28 00:00:00

abstract：BACKGROUND:Typhoid fever remains a major public health problem in low- and middle-income countries where children aged 2-14 years bear the greatest burden. Vi polysaccharide is poorly immunogenic in children <2 years of age, and protection in adults is modest. The limitations of Vi polysaccharide vaccines can be overco...

journal_title：Vaccine

authors： Capeding MR,Teshome S,Saluja T,Syed KA,Kim DR,Park JY,Yang JS,Kim YH,Park J,Jo SK,Chon Y,Kothari S,Yang SY,Ham DS,Ryu JH,Hwang HS,Mun JH,Lynch JA,Kim JH,Kim H,Excler JL,Sahastrabuddhe S

更新日期：2018-06-18 00:00:00

abstract：:Group A rotavirus (RVA) is a major cause of diarrhea and diarrhea-related mortality in foals in parts of the world. In addition to careful horse farm management, vaccination is the only known alternative to reduce the RVA associated disease burden on horse farms. The precise evaluation of vaccine effectiveness against...

journal_title：Vaccine

authors： Papp H,Matthijnssens J,Martella V,Ciarlet M,Bányai K

更新日期：2013-11-19 00:00:00

abstract：:Vaccine exposure to temperatures below recommended ranges in the cold chain may decrease vaccine potency of freeze-sensitive vaccines leading to a loss of vaccine investments and potentially places children at risk of contracting vaccine preventable illnesses. This literature review is an update to one previously publ...

journal_title：Vaccine

authors： Hanson CM,George AM,Sawadogo A,Schreiber B

更新日期：2017-04-19 00:00:00

abstract：:Hepatitis A and B are common infections worldwide and their severity is related to the individual's age upon initial infection. Furthermore, when hepatitis B infection occurs in infants, the risk of becoming a chronic carrier is 90%. For hepatitis A, the lower incidence of disease arising from an improvement in living...

journal_title：Vaccine

authors： Van Damme P,Van der Wielen M

更新日期：2001-03-21 00:00:00