Abstract:
AIM:To investigate the presence of antipituitary antibodies (APA) in the serum of patients undergoing gastroenteropathies (GEP) other than celiac disease (CD). METHODS:APA were analyzed in GEP patients (n = 103), CD patients (n = 94), idiopathic growth hormone (GH) deficiency patients (n = 21), and 98 age- and sex-matched controls. Indirect immunofluorescence was performed in cryostat sections of baboon pituitary gland. RESULTS:APA were detected in 30% of GEP patients, 38% of them showed failure to thrive. No significant differences were found when we compared thrive impairment in negative and positive APA GEP patients. Indeed, normal values of insulin-like growth factor 1 were found in 93% of positive APA GEP patients. APA were detected in 52% of the CD patients. Ninety-one percent of them, in contrast to GEP group, showed significant growth impairment (P < 0.05) when compared to APA negative CD individuals. GH-deficient non-CD patients did not show APA. CONCLUSIONS:We have shown the presence of APA in patients with nongluten-related enteropathies. The presence of antipituitary autoantibodies in GEP patients does not seem to be associated with failure to thrive as it occurs in CD.
journal_name
J Clin Lab Analjournal_title
Journal of clinical laboratory analysisauthors
Aguado R,Fernández S,Estévez OA,Santamaría M,Ortega Cdoi
10.1002/jcla.21644subject
Has Abstractpub_date
2014-01-01 00:00:00pages
59-62issue
1eissn
0887-8013issn
1098-2825journal_volume
28pub_type
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journal_title:Journal of clinical laboratory analysis
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journal_title:Journal of clinical laboratory analysis
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更新日期:1995-01-01 00:00:00
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更新日期:2017-09-01 00:00:00
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更新日期:2005-01-01 00:00:00
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journal_title:Journal of clinical laboratory analysis
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doi:
更新日期:1999-01-01 00:00:00
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journal_title:Journal of clinical laboratory analysis
pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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