Biological activity of the functional epitope of ciguatoxin fragment AB on the neuroblastoma sodium channel in tissue culture.

Abstract:

:It is well established that the targeted receptor for ciguatoxin (CTX) in mammalian tissues is the sodium channel, affecting the influx of sodium into cells and altering the action potential and function of the cell. Since the syntheses of fragments of CTX has become available, our focus has been on the receptor functions of the west sphere AB and east sphere JKLM fragments using the neuroblastoma cell assay, guinea pig atrium assay, and the membrane immunobead assay (MIA). The data presented here suggest that the west sphere AB of the ciguatoxin molecule is the active portion and is responsible for the activation of the sodium channels.

journal_name

J Clin Lab Anal

authors

Hokama Y,Chun KE,Campora CE,Higa N,Suma C,Hamajima A,Isobe M

doi

10.1002/jcla.20114

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

126-32

issue

3

eissn

0887-8013

issn

1098-2825

journal_volume

20

pub_type

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