[Factors associated with treatment adherence for tuberculosis infection].

Abstract:

OBJECTIVE:To analyze adherence to treatment of tuberculosis infection and to identify risk factors for its compliance. DESIGN:An observational historical cohort study. SETTING:Hospital Universitari Sant Joan d'Alacant (Alicante). PARTICIPANTS:All patients with a tuberculin skin test (TST) done during tuberculosis contact tracing during 6 years. RESULTS:We included 764 tuberculosis contacts in the analysis. 59.7% of the 566 patients who completed the contact tracing, had tuberculosis infection (TI). Of the patients with TI, 45.6% had not started treatment for tuberculosis infection (TTBI). Factors associated with not starting TTBI were: age (36-65 years, RR: 5.8; 95% CI: 1.2-27.5, and > 65 years, RR: 11.3; 95% CI: 2.0-64.0), the social relationship with TB case (RR: 2.2; 95% CI 1.2-3.8), and the TST reaction (≥ 15mm; RR: 0.5; 95% CI: 0.3-0.9). The completion rate for TTBI was 80.4% among people who started therapy. The treatment regimen was associated with greater compliance to TTBT (7-9H, RR: 12.7; 95% CI: 1.5-107.3). CONCLUSIONS:The treatment compliance rate of Tuberculosis infection was high among people who started therapy. Almost a half of the contacts with TI did not start treatment, and associated factors were: age, social relationship, and the TST reaction. The treatment regimen was associated with greater compliance. It is important to know the factors associated with adherence to treatment of TI in each health area, and focus efforts on risk groups; thereby approaching the global control of tuberculosis.

journal_name

Aten Primaria

journal_title

Atencion primaria

authors

Gallardo CR,Gea Velázquez de Castro MT,Requena Puche J,Miralles Bueno JJ,Rigo Medrano MV,Aranaz Andrés JM

doi

10.1016/j.aprim.2013.05.009

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

6-14

issue

1

eissn

0212-6567

issn

1578-1275

pii

S0212-6567(13)00189-3

journal_volume

46

pub_type

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