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[Community-acquired pneumonia in patients with chronic obstructive pulmonary disease treated with inhaled corticosteroids or other bronchodilators. Study PNEUMOCORT].

Abstract：

OBJECTIVES:To analyse the risk of pneumonia and/or exacerbations in patients with chronic obstructive pulmonary disease (COPD) who receive treatment with inhaled corticosteroids (CI), in comparison with those who are not treated with inhaled corticosteroids (NCI). To estimate the risk of pneumonia according to CI dose. DESIGN:Population-based cohort study. SETTING:Primary Healthcare. Institut Català de la Salut. PARTICIPANTS:Patients ≥45 years-old diagnosed with COPD between 2007 and 2009 in the Information System for Research in Primary Care (SIDIAP). INTERVENTION:Two cohorts; patients initiating CI and patients initiating bronchodilators after COPD diagnosis. MAIN MEASUREMENTS:Demographics, smoking, medical history, pneumonias, exacerbations, vaccinations, and drug therapy. RESULTS:A total of 3,837 patients were included, 58% in the CI and 42% in the NCI group. Higher incidence rates of pneumonia and exacerbations were detected in the CI group compared with the NCI (2.18 vs. 1.37). The risk of pneumonia and severe exacerbations was not significantly different between groups, HR; 1.17 (95% CI; 0.87-1.56) and 1.06 (95% CI; 0.87-1.31), respectively. Patients in the CI group had a higher risk of mild exacerbations, HR; 1.28 (95% CI; 1.10-1.50). Variables associated with a higher risk of pneumonia were age, diabetes, previous pneumonias and bronchitis, very severe COPD, treatment with low doses of β2-adrenergic or anticholinergic agents, and previous treatment with oral corticosteroids. CONCLUSIONS:There were no differences between cohorts in the risk of pneumonia and severe exacerbations. The risk of mild exacerbations was higher in the CI group. Pneumonias and severe exacerbations were more frequent in patients with severe COPD and in patients receiving high doses of CI.

journal_name

Aten Primaria

journal_title

Atencion primaria

authors

Morros R,Vedia C,Giner-Soriano M,Casellas A,Amado E,Baena JM,en representación de los investigadores del proyecto PNEUMOCORT.

doi

10.1016/j.aprim.2018.02.007

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

333-340

issue

eissn

0212-6567

issn

1578-1275

pii

S0212-6567(17)30358-X

journal_volume

pub_type

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[Community-acquired pneumonia in patients with chronic obstructive pulmonary disease treated with inhaled corticosteroids or other bronchodilators. Study PNEUMOCORT].