[The effects of long-term captopril treatment on the evolution of urinary albumin excretion in patients with non-insulin-dependent diabetes mellitus].

Abstract:

OBJECTIVES:To identify diabetics not dependent on insulin (DNDI) who are carriers of clinical proteinuria and microalbuminuria susceptible to captopril treatment and to evaluate the evolution of the urinary excretion of albumin (UEA) rate after three years of follow-up. DESIGN:A prevalence study followed by an intervention and follow-up over 3 years. SETTING:The urban Health Centre "San Agustín" in Burgos. PATIENTS:107 DNDI included in the "Diabetes programme". INTERVENTIONS:Patients with increased UEA were treated with 25 mg of captopril (Capoten) every 12 hours for 3 years. MEASUREMENTS AND RESULTS:A steady drop in the UEA of patients with microalbuminuria was observed in their third year of treatment (p = 0.01). 5 patients (41.6%) became negative (p = 0.01). CONCLUSIONS:Captopril treatment reduced levels of UEA in DNDI who had high UEA. Significantly, evolution to clinical proteinuria of patients with persistent microalbuminuria was avoided.

journal_name

Aten Primaria

journal_title

Atencion primaria

authors

González Castro ML,Cordero Guevara J,Sáez Fernández A,Sagredo Pérez J,Arrojo Arias E,del Saz Moreno V

subject

Has Abstract

pub_date

1997-09-30 00:00:00

pages

221-8

issue

5

eissn

0212-6567

issn

1578-1275

journal_volume

20

pub_type

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